Yi Wang

TL;DR: Using an adaptation of the in vitro primary epithelial cell culture system, it is found that prostaglandin E2 (PGE2) signaling through one of its receptors, Ptger4, was sufficient to drive a differentiation state morphologically and transcriptionally similar to in vivo WAE cells.

TL;DR: A long-term, self-organizing two-dimensional epithelial monolayer system is established to model the regenerative properties and responses of Hopx+ CARSCs and found that hypoxia and endoplasmic reticulum stress, insults commonly present in inflammatory bowel diseases, mediated the cyclic switch of cellular status in this process.

TL;DR: The importance of Foxp1/4 in restricting cell fate choices during development and regeneration is demonstrated, thereby providing the proper balance of functional epithelial lineages in the lung.

TL;DR: A platform for complete life cycle development and long-term growth of C. parvum in vitro using “air-liquid interface” (ALI) cultures derived from intestinal epithelial stem cells is described.

TL;DR: It is shown that development of Sox2+ progenitors in the lung endoderm is regulated by histone deacetylases 1 and 2 (Hdac1/2), which have both common and unique targets that differentially regulate tissue-specific progenitor activity during development and regeneration.