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Ying Wooi Wan
Researcher at Baylor College of Medicine
Publications - 16
Citations - 1469
Ying Wooi Wan is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Neurodegeneration & Ataxin 1. The author has an hindex of 11, co-authored 16 publications receiving 1037 citations. Previous affiliations of Ying Wooi Wan include University of Texas Health Science Center at Houston & Boston Children's Hospital.
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Journal ArticleDOI
Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia
Jiangbin Ye,Jing Fan,Sriram Venneti,Ying Wooi Wan,Bruce R. Pawel,Ji Zhang,Lydia W.S. Finley,Chao Lu,Tullia Lindsten,Justin R. Cross,Guoliang Qing,Zhandong Liu,M. Celeste Simon,Joshua D. Rabinowitz,Craig B. Thompson +14 more
TL;DR: It is demonstrated that the serine catabolic enzyme SHMT2 is induced upon hypoxic stress and is critical for maintaining NADPH production and redox balance to support tumor cell survival and growth.
Journal ArticleDOI
A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases
Shinya Yamamoto,Manish Jaiswal,Wu Lin Charng,Tomasz Gambin,Ender Karaca,Ghayda M. Mirzaa,Ghayda M. Mirzaa,Wojciech Wiszniewski,Hector Sandoval,Nele A Haelterman,Bo Xiong,Ke Zhang,Vafa Bayat,Gabriela David,Tongchao Li,Kuchuan Chen,Upasana Gala,Tamar Harel,Davut Pehlivan,Samantha Penney,Lisenka E.L.M. Vissers,Joep de Ligt,Shalini N. Jhangiani,Yajing Xie,Stephen H. Tsang,Yesim Parman,Merve Sivaci,Esra Battaloglu,Donna M. Muzny,Ying Wooi Wan,Zhandong Liu,Alexander T. Lin-Moore,Robin D. Clark,Cynthia J. Curry,Nichole Link,Karen L. Schulze,Eric Boerwinkle,William B. Dobyns,William B. Dobyns,Rando Allikmets,Richard A. Gibbs,Rui Chen,James R. Lupski,Michael F. Wangler,Hugo J. Bellen +44 more
TL;DR: A mosaic genetic screen of lethal mutations on the Drosophila X chromosome is conducted to identify genes required for the development, function, and maintenance of the nervous system and to provide insights into microcephaly associated with brain dysgenesis.
Journal ArticleDOI
Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
Alexandra Litvinchuk,Ying Wooi Wan,Dan B. Swartzlander,Fading Chen,Allysa L. Cole,Nicholas E. Propson,Qian Wang,Bin Zhang,Zhandong Liu,Hui Zheng +9 more
TL;DR: It is shown that the expression of C3 and C3a receptor (C3aR1) are positively correlated with cognitive decline and Braak staging in human AD brains and a crucial role for activation of the C3-C3 aR network in mediating neuroinflammation and tau pathology is demonstrated.
Journal ArticleDOI
Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Hsiang Chih Lu,Hsiang Chih Lu,Qiumin Tan,Maxime W.C. Rousseaux,Wei Wang,Ji-Yoen Kim,Ronald Richman,Ying Wooi Wan,Szu Ying Yeh,Jay M. Patel,Xiuyun Liu,Tao Lin,Yoontae Lee,Yoontae Lee,John D. Fryer,John D. Fryer,Jing Han,Jing Han,Maria H. Chahrour,Maria H. Chahrour,Richard H. Finnell,Yunping Lei,Maria E. Zurita-Jimenez,Priyanka Ahimaz,Kwame Anyane-Yeboa,Lionel Van Maldergem,Daphné Lehalle,Nolwenn Jean-Marçais,Anne Laure Mosca-Boidron,Julien Thevenon,Margot A. Cousin,Della E. Bro,Brendan C. Lanpher,Eric W. Klee,Nora Alexander,Matthew N. Bainbridge,Harry T. Orr,Roy V. Sillitoe,M. Cecilia Ljungberg,Zhandong Liu,Christian P. Schaaf,Huda Y. Zoghbi +41 more
TL;DR: This study demonstrates that loss of ATXN1–CIC complexes causes a spectrum of neurobehavioral phenotypes, including intellectual disability, attention deficit/hyperactivity disorder (ADHD), and autism spectrum disorder.
Journal ArticleDOI
The bone microenvironment invigorates metastatic seeds for further dissemination
Weijie Zhang,Igor Bado,Jingyuan Hu,Jingyuan Hu,Ying Wooi Wan,Ying Wooi Wan,Ling Wu,Hai Wang,Yang Gao,Hyun-Hwan Jeong,Hyun-Hwan Jeong,Zhan Xu,Xiaoxin Hao,Bree M. Lege,Rami Al-Ouran,Rami Al-Ouran,Lucian Li,Lucian Li,Jiasong Li,Liqun Yu,Swarnima Singh,Hin Ching Lo,Muchun Niu,Jun Liu,Weiyu Jiang,Yi Li,Stephen T. C. Wong,Stephen T. C. Wong,Chonghui Cheng,Zhandong Liu,Zhandong Liu,Xiang Zhang +31 more
TL;DR: In this paper, the bone microenvironment facilitates breast and prostate cancer cells to further metastasize and establish multi-organ secondary metastases, and the metastasis-promoting effect is driven by epigenetic reprogramming.