Z
Zenia M Størling
Researcher at Technical University of Denmark
Publications - 8
Citations - 1321
Zenia M Størling is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Candidate gene & Gene. The author has an hindex of 5, co-authored 5 publications receiving 1272 citations. Previous affiliations of Zenia M Størling include Steno Diabetes Center.
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Journal ArticleDOI
A human phenome-interactome network of protein complexes implicated in genetic disorders
Kasper Lage,E. Olof Karlberg,Zenia M Størling,Páll Ísólfur Ólason,Anders Gorm Pedersen,Olga Rigina,Anders M. Hinsby,Zeynep Tümer,Flemming Pociot,Flemming Pociot,Niels Tommerup,Yves Moreau,Søren Brunak +12 more
TL;DR: A Bayesian predictor is developed that identifies novel candidates implicated in disorders such as retinitis pigmentosa, epithelial ovarian cancer, inflammatory bowel disease, amyotrophic lateral sclerosis, Alzheimer disease, type 2 diabetes and coronary heart disease.
Journal ArticleDOI
The implications of alternative splicing in the ENCODE protein complement
Michael L. Tress,Pier Luigi Martelli,Adam Frankish,Gabrielle A. Reeves,Jan-Jaap Wesselink,Corin Yeats,Páll ĺsólfur Ólason,Mario Albrecht,Hedi Hegyi,Alejandro Giorgetti,Domenico Raimondo,Julien Lagarde,Roman A. Laskowski,Gonzalo Lopez,Michael I. Sadowski,James D. Watson,Piero Fariselli,Ivan Rossi,Alinda Nagy,Wang Kai,Zenia M Størling,Massimiliano Orsini,Yassen Assenov,Hagen Blankenburg,Carola Huthmacher,Fidel Ramírez,Andreas Schlicker,Phil Jones,Samuel Kerrien,Sandra Orchard,Stylianos E. Antonarakis,Alexandre Reymond,Ewan Birney,Søren Brunak,Rita Casadio,Roderic Guigó,Jennifer Harrow,Henning Hermjakob,David T. Jones,Thomas Lengauer,Christine A. Orengo,László Patthy,Janet M. Thornton,Anna Tramontano,Alfonso Valencia +44 more
TL;DR: It is found that alternative splicing in human genes is more frequent than has commonly been suggested, and it is demonstrated that many of the potential alternative gene products will have markedly different structure and function from their constitutively spliced counterparts.
Journal ArticleDOI
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
Lukas Adrian Berchtold,Zenia M Størling,Fernanda Ortis,Kasper Lage,Kasper Lage,Claus Heiner Bang-Berthelsen,Regine Bergholdt,Jacob Hald,Caroline Brorsson,Decio L. Eizirik,Flemming Pociot,Søren Brunak,Søren Brunak,Joachim Størling +13 more
TL;DR: This study demonstrates that the current network biology approach is a valid method to identify genes of importance for T1D and may therefore embody the basis for more rational and targeted therapeutic approaches.
Journal ArticleDOI
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
Regine Bergholdt,Zenia M Størling,Kasper Lage,E. Olof Karlberg,Páll Ísólfur Ólason,Mogens Aalund,Jørn Nerup,Jørn Nerup,Søren Brunak,Christopher T. Workman,Flemming Pociot,Flemming Pociot +11 more
TL;DR: An integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network is developed, which identified a number of new protein network modules and novel candidate genes/proteins for type 1 Diabetes.
Journal ArticleDOI
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.
Allan E. Karlsen,Zenia M Størling,T. Sparre,Martin R. Larsen,Amer Mahmood,Joachim Størling,Peter Roepstorff,Krzysztof Wrzesinski,Peter Mose Larsen,Stephen J. Fey,Karin Nielsen,Peter E. Heding,Camillo Ricordi,Jesper Johannesen,O. P. Kristiansen,Ulla Bjerre Christensen,Ingrid Kockum,Holger Luthman,Jørn Nerup,Flemming Pociot,Flemming Pociot +20 more
TL;DR: Combined proteome-transcriptome-genome and functional analyses identify gal-3 as a candidate gene/protein in T1D susceptibility that may prove valuable in future intervention/prevention strategies.