O
Olga Rigina
Researcher at Technical University of Denmark
Publications - 8
Citations - 1817
Olga Rigina is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Interaction network & Gene. The author has an hindex of 6, co-authored 8 publications receiving 1631 citations. Previous affiliations of Olga Rigina include The Breast Cancer Research Foundation.
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Journal ArticleDOI
A human phenome-interactome network of protein complexes implicated in genetic disorders
Kasper Lage,E. Olof Karlberg,Zenia M Størling,Páll Ísólfur Ólason,Anders Gorm Pedersen,Olga Rigina,Anders M. Hinsby,Zeynep Tümer,Flemming Pociot,Flemming Pociot,Niels Tommerup,Yves Moreau,Søren Brunak +12 more
TL;DR: A Bayesian predictor is developed that identifies novel candidates implicated in disorders such as retinitis pigmentosa, epithelial ovarian cancer, inflammatory bowel disease, amyotrophic lateral sclerosis, Alzheimer disease, type 2 diabetes and coronary heart disease.
Journal ArticleDOI
A scored human protein–protein interaction network to catalyze genomic interpretation
Taibo Li,Rasmus Wernersson,Rasmus Borup Hansen,Heiko Horn,Heiko Horn,Johnathan Mercer,Johnathan Mercer,Grzegorz Slodkowicz,Christopher T. Workman,Olga Rigina,Kristoffer Rapacki,Hans Henrik Stærfeldt,Søren Brunak,Thomas Skøt Jensen,Kasper Lage +14 more
TL;DR: It is illustrated that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism and better functional biological relevance than comparable resources.
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PSICQUIC and PSISCORE: accessing and scoring molecular interactions
Bruno Aranda,Hagen Blankenburg,Samuel Kerrien,Fiona S. L. Brinkman,Arnaud Ceol,Emilie Chautard,Jose M. Dana,Javier De Las Rivas,Marine Dumousseau,Eugenia Galeota,Anna Gaulton,Johannes B. Goll,Robert E. W. Hancock,Ruth Isserlin,Rafael C. Jimenez,Jules Kerssemakers,Jyoti Khadake,David J. Lynn,Magali Michaut,Gavin O'Kelly,Keiichiro Ono,Sandra Orchard,Carlos Prieto,Sabry Razick,Olga Rigina,Lukasz Salwinski,Milan Simonovic,Sameer Velankar,Andrew G. Winter,Guanming Wu,Gary D. Bader,Gianni Cesareni,Ian Donaldson,David Eisenberg,Gerard J. Kleywegt,John P. Overington,Sylvie Ricard-Blum,Mike Tyers,Mario Albrecht,Henning Hermjakob +39 more
TL;DR: To study proteins in the context of a cellular system, it is essential that the molecules with which a protein interacts are identified and the functional consequence of each interaction is understood.
Journal ArticleDOI
Dissecting spatio-temporal protein networks driving human heart development and related disorders
Kasper Lage,Kjeld Møllgård,Steven C. Greenway,Hiroko Wakimoto,Joshua M. Gorham,Christopher T. Workman,Eske Bendsen,Niclas Tue Hansen,Olga Rigina,Francisco S. Roque,Francisco S. Roque,Cornelia Wiese,Vincent M. Christoffels,Amy E. Roberts,Amy E. Roberts,Leslie B. Smoot,William T. Pu,William T. Pu,Patricia K. Donahoe,Patricia K. Donahoe,Niels Tommerup,Søren Brunak,Søren Brunak,Christine E. Seidman,Jonathan G. Seidman,Lars Allan Larsen +25 more
TL;DR: This analysis elucidates the organization and composition of spatio‐temporal protein networks that drive the formation of organs, which in the future may lay the foundation of novel approaches in treatments, diagnostics, and regenerative medicine.
Journal ArticleDOI
TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression.
Christina Annette Bjerre,Christina Annette Bjerre,Lena Vinther,Lena Vinther,Kirstine Belling,Kirstine Belling,Sidse Ørnbjerg Würtz,Rachita Yadav,Rachita Yadav,Ulrik Lademann,Ulrik Lademann,Olga Rigina,Olga Rigina,Khoa Nguyen Do,Henrik J. Ditzel,Henrik J. Ditzel,Henrik J. Ditzel,Anne E. Lykkesfeldt,Jun Wang,Henrik Nielsen,Nils Brünner,Nils Brünner,Ramneek Gupta,Ramneek Gupta,Anne-Sofie Schrohl,Anne-Sofie Schrohl,Jan Stenvang,Jan Stenvang +27 more
TL;DR: The data suggest that high tumor levels of TIMP1 may be a predictive biomarker for reduced response to fulvestrant, andGene and protein expression analyses showed no general defects in estrogen receptor signaling except from lack of progesterone receptor expression and estrogen inducibility in clones with high TimP1.