Zichun Xiang

TL;DR: It is shown that the SARS-CoV-2 spike protein is less stable than that of SARS -CoV, and limited cross-neutralization activities between SARS and COVID-19 patients’ sera showlimited cross- neutralization activities, suggesting that recovery from one infection might not protect against the other.

TL;DR: This study shows that Sars-CoV-2 perturbs host innate immune response via both its structural and nonstructural proteins, and thus provides insights into the pathogenesis of SARS-Cov-2.

TL;DR: The viral detection rates differed significantly between infections of the lower and upper respiratory tracts in the sample population: PIVs, the second most commonly detected viral agents in lower acute respiratory tract infections (LRTIs), were more prevalent than in upper acute respiratory tracts, indicating that the pathogenic role of Pivs in LRTIs should be investigated.

TL;DR: Wang et al. as discussed by the authors reported that SARS-CoV-2 nsp12, the viral RNA-dependent RNA polymerase (RdRp), suppresses host antiviral responses.

TL;DR: During August 2006–April 2010, in Beijing, China, 2 rare humanEnterovirus serotypes, coxsackievirus A21 and enterovirus 68, were detected most frequently in human enterov virus–positive adults with acute respiratory tract infections.