Chaminade University of Honolulu

About: Chaminade University of Honolulu is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Experiential learning. The organization has 164 authors who have published 223 publications receiving 5381 citations.

High-mobility group box 1 is a driver of inflammation throughout pregnancy

Abstract: A proinflammatory response driven by high-mobility group box 1 (HMGB1) is important for the success of both the early stages of pregnancy and parturition initiation. However, the tight regulation of HMGB1 within these two stages is critical, as increased HMGB1 can manifest into pregnancy-related pathologies. Although during the early stages of pregnancy HMGB1 is critical for the development and implantation of the embryo, and uterine decidualization, high levels within the uterine cavity have been linked to pregnancy failure. In addition, chronic inflammation, resultant from increased HMGB1 within the maternal circulation and gestational tissues, also increases the risk for preterm labor, preterm birth, or infant mortality. Due to the link between HMGB1 and several pregnancy pathologies, the possibility of leveraging HMGB1 as a biomarker has been assessed. However, data are limited that demonstrate how known HMGB1 inhibitors could reduce inflammation within pregnancy. Thus, further research is warranted to improve our understanding of the potential of HMGB1 as a therapeutic target to reduce inflammation within pregnancy. This review aims to describe what is understood about the role of HMGB1 that drives inflammation throughout pregnancy and highlight its potential as a biomarker and therapeutic target within this context.

Assessing organizational stability via network analysis

Abstract: It is widely known that the email system forms a social network. Analysis of email networks reveals properties similar to classic social networks such as friendship or academic collaboration networks. Like other social networks, the properties observed in email networks are the result of patterns of human social behavior rather than the underlying technology. Hence, email social network properties correlate to the social environment in which they are generated. The overall social behavior observed in an organization may be attributed directly to organizational stability and robustness. As a result, organizational health and robustness may be discerned by examining the social network properties of the network formed by the email interaction of its employees because they certainly reflect changes in organizational mood. The fears, worries, gossips, the good and the bad, are reflected in the email activity of individuals in the organization; the challenge though is to extract his information from the network itself. In this paper we provide a first step in the process of demonstrating that email social network analysis can tell us more about the organization than we may think; we show using a case study based on the Enron corporation that problems in the organization were apparent as an emergent characteristic of social network formed by email exchange in the organization.

Ozone Exposure Affects Feeding and Locomotor Behavior of Adult Bufo Marinus

Abstract: Ozone (O3), a reactive component of air pollution, depresses feeding and voluntary locomotor behavior in laboratory rodents, but the effects of O3 on amphibian behavior are not known. We evaluated the effects of 4 h of exposure to air or ozone (0.6 l/L), on two ecologically relevant behaviors of the toad Bufo marinus. Toads were offered five mealworms at 1, 24, and 48 h after exposure. One hour after exposure, O3-exposed toads ate fewer mealworms than did air-exposed toads (Fisher exact test, p 0.005). Within 24 h after exposure, all toads ate four or five mealworms. Because movement is a key component of toad feeding behavior, we tested additional toads (n 25) for voluntary locomotor behavior during three 1-h trials in a 2.9-m 2 open-field arena. Mean ( standard deviation) total distance moved was: pre-exposure, 29 19.5 m; 1-h postexposure, 13 15.6 m; and 24-h postexposure, 17 17.4 m. The means were not statistically different by repeated measures analysis of covariance. Therefore, our results suggest that a single 4-h exposure to O3 depresses toad feeding behavior after exposure but had little effect on voluntary locomotor behavior.

Emotional Impact of Cardiopulmonary Resuscitation Training on High School Students.

Abstract: Background: The American Heart Association (AHA) has implemented several programs to educate the public about cardiopulmonary resuscitation (CPR). A common issue in bystander CPR is the fear of hurting the victim. As a result, the victim may not receive CPR in time. The purpose of this study was to measure the emotional impact of CPR training on high school students using two approved AHA courses. Methods: A total of 60 students participated in this study. These students had a mean age of 15.4±1.2 years old and were selected from a high school in Southern California. Subjects were divided into two groups, Basic Life Support (BLS) (n1=31) and Hands-Only CPR (n2=29). Emotional impacts were assessed by having each subject answer a questionnaire based on given scenarios before and after their training session. Results: There was a significant difference in both groups when comparing positive-emotion scores before and after the training (BLS: 30.3± 6.0 vs. 34.5±6.7, p < 0.001; Hands-only 27.9±5.0 vs. 32.1±6.5, p<0.001). In addition, both groups showed significant reductions in negative-emotion scores (BLS:29.2±6.7 vs. 23.7±6.5, p< 0.001 and Hands-Only:26.8±6.1vs. 24.8±7.7, p=0.05). Conclusion: Our results indicate that the AHA programs have positive effects on students’ emotional response. We recommend that future studies include an in-depth study design that probes the complexity of students’ emotions after completing an AHA session.

Genomic Competencies for Nursing Practice: Implications for Nursing Leadership.

Abstract: Nurses must have appropriate knowledge and skills to provide safe and effective nursing care in recognition of evolving science. Knowledge of genomics is required to ensure appropriate referral and education of patients who would benefit from genetic services. This article describes the process the Veterans Healthcare Administration's (VHA's) Office of Nursing Services used to determine the nursing genomic competencies appropriate for VHA nurses and identify available resources for educating nurses on these nursing competencies and a strategic plan for long-term implementation.