Institution
Churchill Hospital
Healthcare•Oxford, United Kingdom•
About: Churchill Hospital is a healthcare organization based out in Oxford, United Kingdom. It is known for research contribution in the topics: Population & Transplantation. The organization has 3548 authors who have published 5357 publications receiving 304275 citations.
Topics: Population, Transplantation, Cancer, Diabetes mellitus, Type 2 diabetes
Papers published on a yearly basis
Papers
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TL;DR: It is shown that GTF2IRD1 is a genetic determinant of mammalian craniofacial and cognitive development, and a mechanism of cumulative dosage effects of duplicated and diverged genes applicable to other human chromosomal disorders is proposed.
Abstract: Craniofacial abnormalities account for about one-third of all human congenital defects, but our understanding of the genetic mechanisms governing craniofacial development is incomplete. We show that GTF2IRD1 is a genetic determinant of mammalian craniofacial and cognitive development, and we implicate another member of the TFII-I transcription factor family, GTF2I, in both aspects. Gtf2ird1-null mice exhibit phenotypic abnormalities reminiscent of the human microdeletion disorder Williams-Beuren syndrome (WBS); craniofacial imaging reveals abnormalities in both skull and jaws that may arise through misregulation of goosecoid, a downstream target of Gtf2ird1. In humans, a rare WBS individual with an atypical deletion, including GTF2IRD1, shows facial dysmorphism and cognitive deficits that differ from those of classic WBS cases. We propose a mechanism of cumulative dosage effects of duplicated and diverged genes applicable to other human chromosomal disorders.
208 citations
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TL;DR: The epidemiology and pathogenesis of malignant pleural mesothelioma is summarized, before describing some key factors in the patient experience and outlining common symptoms.
Abstract: Malignant pleural mesothelioma is an aggressive malignancy of the pleural surface, predominantly caused by prior asbestos exposure. There is a global epidemic of malignant pleural mesothelioma underway, and incidence rates are predicted to peak in the next few years.This article summarises the epidemiology and pathogenesis of malignant pleural mesothelioma, before describing some key factors in the patient experience and outlining common symptoms. Diagnostic approaches are reviewed, including imaging techniques and the role of various biomarkers. Treatment options are summarised, including the importance of palliative care and methods of controlling pleural effusions. The evidence for chemotherapy, radiotherapy and surgery is reviewed, both in the palliative setting and in the context of trimodality treatment. An algorithm for managing malignant pleural effusion in malignant pleural mesothelioma patients is presented. Finally new treatment developments and novel therapeutic approaches are summarised.
208 citations
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TL;DR: Based on the dose estimation part of this study the recommended dose of strontium-89 is 150 MBq, provided platelet levels were above 100 x 10(9) l-1 at the time of treatment and Toxicity was low.
Abstract: In a multi-centre study strontium-89 was shown to be effective in relieving bone pain from prostatic carcinoma in patients who had failed conventional therapies. Of 83 patients assessed at 3 months, following the administration of a dose of at least 1.5 MBq/kg, 75% derived benefit and 22% became pain free. Symptomatic improvement usually occurred within 6 weeks and continued for between 4 and 15 months (mean 6 months). Based on the dose estimation part of this study the recommended dose of strontium-89 is 150 MBq. Toxicity was low, provided platelet levels were above 100 × 1091−1 at the time of treatment. Repeat treatments with strontium-89 may be given at intervals of not less than 3 months. Strontium-89 is administered intravenously on an out-patient basis with no special radiological protection precautions.
207 citations
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TL;DR: Obesity is associated with the increased expression of several chemokine genes in adipose tissue, however, only MCP1 is secreted into the extracellular space, where it primarily acts as a local factor, because little or no spillover into the circulation occurs.
Abstract: A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects.
207 citations
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Carlos III Health Institute1, Lund University2, Memorial Sloan Kettering Cancer Center3, University of Melbourne4, Peter MacCallum Cancer Centre5, Central Manchester University Hospitals NHS Foundation Trust6, Princess Anne Hospital7, Leiden University Medical Center8, Radboud University Nijmegen9, Pomeranian Medical University10, NorthShore University HealthSystem11, University of Chicago12, Repatriation General Hospital13, Erasmus University Rotterdam14, University Medical Center Groningen15, Boston Children's Hospital16, Royal Hallamshire Hospital17, Huntsman Cancer Institute18, University Medical Center Utrecht19, University of Pennsylvania20, McGill University21, Netherlands Cancer Institute22, Maastricht University23, Guy's Hospital24, VU University Medical Center25, Churchill Hospital26, University of New South Wales27, University of Sydney28, St George's Hospital29, University of Cambridge30, Royal Brisbane and Women's Hospital31, Hospital de Sant Pau32, King Edward Memorial Hospital33, University of Western Australia34, St. Vincent's Health System35, Karolinska University Hospital36, Royal Devon and Exeter Hospital37, St. Michael's GAA, Sligo38, Reykjavík University39, Kaplan Medical Center40, University Hospitals of Leicester NHS Trust41, Fox Chase Cancer Center42, University of Texas MD Anderson Cancer Center43, Mater Misericordiae University Hospital44, RMIT University45, Imperial College Healthcare46, Umeå University47, University College London48, Nottingham City Hospital49, Queen Mary University of London50
TL;DR: The IMPACT screening network is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations.
206 citations
Authors
Showing all 3565 results
Name | H-index | Papers | Citations |
---|---|---|---|
Mark I. McCarthy | 200 | 1028 | 187898 |
Adrian L. Harris | 170 | 1084 | 120365 |
Nicholas J. White | 161 | 1352 | 104539 |
Andrew T. Hattersley | 146 | 768 | 106949 |
Paul Harrison | 133 | 1400 | 80539 |
John F. Thompson | 132 | 1420 | 95894 |
Thomas N. Williams | 132 | 1145 | 95109 |
Kevin Marsh | 128 | 567 | 55356 |
Mark Sullivan | 126 | 802 | 63916 |
Adrian V. S. Hill | 122 | 589 | 64613 |
Ian Tomlinson | 119 | 607 | 55576 |
Richard J.H. Smith | 118 | 1308 | 61779 |
Angela Vincent | 116 | 843 | 52784 |
Cecilia M. Lindgren | 115 | 368 | 89219 |
François Nosten | 114 | 777 | 50823 |