Institution
Cognition and Brain Sciences Unit
Facility•Cambridge, United Kingdom•
About: Cognition and Brain Sciences Unit is a facility organization based out in Cambridge, United Kingdom. It is known for research contribution in the topics: Cognition & Semantic memory. The organization has 801 authors who have published 3055 publications receiving 257962 citations.
Topics: Cognition, Semantic memory, Working memory, Recall, Population
Papers published on a yearly basis
Papers
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TL;DR: It is concluded that patients with progressive supranuclear palsy have a multimodal deficit in social cognition, due in part to progressive atrophy in a network of frontal cortical regions linked to the integration of socially relevant stimuli and interpretation of their social meaning.
Abstract: Although progressive supranuclear palsy is defined by its akinetic rigidity, vertical supranuclear gaze palsy and falls, cognitive impairments are an important determinant of patients’ and carers’ quality of life. Here, we investigate whether there is a broad deficit of modality-independent social cognition in progressive supranuclear palsy and explore the neural correlates for these. We recruited 23 patients with progressive supranuclear palsy (using clinical diagnostic criteria, nine with subsequent pathological confirmation) and 22 age- and education-matched controls. Participants performed an auditory (voice) emotion recognition test, and a visual and auditory theory of mind test. Twenty-two patients and 20 controls underwent structural magnetic resonance imaging to analyse neural correlates of social cognition deficits using voxel-based morphometry. Patients were impaired on the voice emotion recognition and theory of mind tests but not auditory and visual control conditions. Grey matter atrophy in patients correlated with both voice emotion recognition and theory of mind deficits in the right inferior frontal gyrus, a region associated with prosodic auditory emotion recognition. Theory of mind deficits also correlated with atrophy of the anterior rostral medial frontal cortex, a region associated with theory of mind in health. We conclude that patients with progressive supranuclear palsy have a multimodal deficit in social cognition. This deficit is due, in part, to progressive atrophy in a network of frontal cortical regions linked to the integration of socially relevant stimuli and interpretation of their social meaning. This impairment of social cognition is important to consider for those managing and caring for patients with progressive supranuclear palsy.
98 citations
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TL;DR: An "interleaved silent steady state" (ISSS) sampling scheme in which a set of EPI volumes are rapidly acquired following each silent stimulus presentation period, which has a temporal resolution like event-related (ER) imaging within a single trial.
98 citations
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TL;DR: It is shown that sensorimotor attenuation occurs in 98% of adults in a population-based cohort and that ageing alters the balance between the sensorium and predictive models, mediated by the pre-SMA and its connectivity in frontostriatal circuits.
Abstract: The control of voluntary movement changes markedly with age. A critical component of motor control is the integration of sensory information with predictions of the consequences of action, arising from internal models of movement. This leads to sensorimotor attenuation-a reduction in the perceived intensity of sensations from self-generated compared with external actions. Here we show that sensorimotor attenuation occurs in 98% of adults in a population-based cohort (n=325; 18-88 years; the Cambridge Centre for Ageing and Neuroscience). Importantly, attenuation increases with age, in proportion to reduced sensory sensitivity. This effect is associated with differences in the structure and functional connectivity of the pre-supplementary motor area (pre-SMA), assessed with magnetic resonance imaging. The results suggest that ageing alters the balance between the sensorium and predictive models, mediated by the pre-SMA and its connectivity in frontostriatal circuits. This shift may contribute to the motor and cognitive changes observed with age.
98 citations
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TL;DR: It is suggested that the DMN encodes scene, episode or context, by integrating spatial, self‐referential, and temporal information, and Context representations are strong at rest, but rereference to context also occurs at major cognitive transitions.
Abstract: A frequently repeated finding is that the default mode network (DMN) shows activation decreases during externally focused tasks. This finding has led to an emphasis in DMN research on internally focused self-relevant thought processes. A recent study, in contrast, implicates the DMN in substantial externally focused task switches. Using functional magnetic resonance imaging, we scanned 24 participants performing a task switch experiment. Whilst replicating previous DMN task switch effects, we also found large DMN increases for brief rests as well as task restarts after rest. Our findings are difficult to explain using theories strictly linked to internal or self-directed cognition. In line with principal results from the literature, we suggest that the DMN encodes scene, episode or context, by integrating spatial, self-referential, and temporal information. Context representations are strong at rest, but rereference to context also occurs at major cognitive transitions.
98 citations
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TL;DR: A quadratic relationship between LC CR and age is found, the peak occurring around 60 years, with no differences between males and females, and regional analyses revealed that age-related decline in LC CR was confined to the rostral portion of the LC.
97 citations
Authors
Showing all 815 results
Name | H-index | Papers | Citations |
---|---|---|---|
Trevor W. Robbins | 231 | 1137 | 164437 |
Simon Baron-Cohen | 172 | 773 | 118071 |
Edward T. Bullmore | 165 | 746 | 112463 |
John R. Hodges | 149 | 812 | 82709 |
Barbara J. Sahakian | 145 | 612 | 69190 |
Steven Williams | 144 | 1375 | 86712 |
Alan D. Baddeley | 137 | 467 | 89497 |
John S. Duncan | 130 | 898 | 79193 |
Adrian M. Owen | 107 | 452 | 51298 |
John D. Pickard | 107 | 628 | 42479 |
Dorothy V. M. Bishop | 104 | 377 | 37096 |
David M. Clark | 102 | 370 | 40943 |
David K. Menon | 102 | 732 | 40046 |
Karalyn Patterson | 101 | 291 | 40802 |
Roger A. Barker | 101 | 620 | 39728 |