Georgetown University

About: Georgetown University is a education organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 23377 authors who have published 43718 publications receiving 1748598 citations. The organization is also known as: GU & Georgetown.

Nerve growth factor treatment after brain injury prevents neuronal death

Abstract: Cholinergic neuronal degeneration after axotomy has been proposed to be due to the loss of a retrogradely transported neurotrophic factor, possibly nerve growth factor (NGF). To test this hypothesis, NGF was continuously infused into the lateral ventricles of adult rats that had received bilateral lesions of all cholinergic axons projecting from the medial septum to the dorsal hippocampus. After 2 weeks of NGF treatment, identification of cholinergic neurons by the presence of the biosynthetic enzyme choline acetyltransferase revealed a dramatic increase (350%) in the survival of the axotomized septal cholinergic neurons. Thus, NGF or an NGF-like molecule can act as a neurotrophic factor for these neurons.

Knowledge sourcing by foreign multinationals: Patent citation analysis in the U.S. semiconductor industry

Abstract: Do multinationals go abroad to acquire technological knowledge? Do they also contribute knowledge locally? We investigate the learning and contribution patterns of multinational firms in the U.S. semiconductor industry through the analysis of citations to their patents and through field interviews. We find that the knowledge used in innovation by foreign subsidiaries in U.S. regions is predominantly local (at the regional and country level). In fact, foreign firms use regional knowledge significantly more than similar domestic firms. In the case of European and Korean firms, foreign investment is directed towards offsetting home country technological weaknesses. The study finds that foreign firms also contribute to local technological progress—a significant proportion of the citations to their patents are local. Local learning without contributing may not be possible.

Who Is Against Immigration? A Cross-Country Investigation of Individual Attitudes toward Immigrants

Abstract: This paper empirically analyzes economic and noneconomic determinants of individual attitudes toward immigrants, within and across countries. The two survey data sets used, covering a wide range of developed and developing countries, make it possible to test for interactive effects between individual characteristics and country-level attributes. In particular, theory predicts that the correlation between pro-immigration attitudes and individual skill should be related to the skill composition of natives relative to immigrants in the destination country. Skilled individuals should favor immigration in countries where natives are more skilled than immigrants and oppose it otherwise. Results based on direct and indirect measures of the relative skill composition are consistent with these predictions. Noneconomic variables also are correlated with immigration attitudes, but they don't alter significantly the labor-market results.

Strategic planning in a turbulent environment: evidence from the oil majors

Abstract: The long-running debate between the ‘rational design’ and ‘emergent process’ schools of strategy formation has involved caricatures of firms' strategic planning processes, but little empirical evidence of whether and how companies plan. Despite the presumption that environmental turbulence renders conventional strategic planning all but impossible, the evidence from the corporate sector suggests that reports of the demise of strategic planning are greatly exaggerated. The goal of this paper is to fill this empirical gap by describing the characteristics of the strategic planning systems of multinational, multibusiness companies faced with volatile, unpredictable business environments. In-depth case studies of the planning systems of eight of the world's largest oil companies identified fundamental changes in the nature and role of strategic planning since the end of the 1970s. The findings point to a possible reconciliation of ‘design’ and ‘process’ approaches to strategy formulation. The study pointed to a process of planned emergence in which strategic planning systems provided a mechanism for coordinating decentralized strategy formulation within a structure of demanding performance targets and clear corporate guidelines. The study shows that these planning systems fostered adaptation and responsiveness, but showed limited innovation and analytical sophistication. Copyright © 2003 John Wiley & Sons, Ltd.

Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting : a randomized controlled trial of text message reminders

Abstract: This brief summarizes the results of a gender impact evaluation study, entitled Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting : a randomized controlled trial of text message reminders, conducted between June 2007 to August 2008 in Kenya. The study observed that there is limited evidence on whether growing mobile phone availability in sub-Saharan Africa can be used to promote high adherence to antiretroviral therapy (ART). This study tested the efficacy of short message service (SMS) reminders on adherence to ART among patients attending a rural clinic in Kenya. In intention-to-treat analysis, 53 percent of participants receiving weekly SMS reminders achieved adherence of at least 90 percent during the 48 weeks of the study, compared with 40 percent of participants in the control group, the difference is significant. Funding for the study derived from the World Bank Research Group, Bank-Netherlands Partnership Program, USAID AMPATH Partnership, National Institute of Mental Health.