Institution
Georgetown University
Education•Washington D.C., District of Columbia, United States•
About: Georgetown University is a education organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 23377 authors who have published 43718 publications receiving 1748598 citations. The organization is also known as: GU & Georgetown.
Topics: Population, Cancer, Breast cancer, Health care, Politics
Papers published on a yearly basis
Papers
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TL;DR: Traumatic spinal cord injury in socioeconomically advanced countries, has a probably annual incidence rate of 3 per 100 000 population, and males are affected five times as often as females, and in the US, Negroes have twice the rates of whites.
369 citations
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University of California, San Francisco1, University of Texas MD Anderson Cancer Center2, University of Pennsylvania3, University of North Carolina at Chapel Hill4, Memorial Sloan Kettering Cancer Center5, Oregon Health & Science University6, Lawrence Berkeley National Laboratory7, University of Alabama8, Yeshiva University9, University of Southern California10, University of Washington11, Georgetown University12, University of Chicago13, Yale University14, New York University15
TL;DR: PCR is more highly predictive of RFS within every established receptor subset than overall, demonstrating that the extent of outcome advantage conferred by pCR is specific to tumor biology.
Abstract: Purpose Neoadjuvant chemotherapy for breast cancer provides critical information about tumor response; how best to leverage this for predicting recurrence-free survival (RFS) is not established. The I-SPY 1 TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging and Molecular Analysis) was a multicenter breast cancer study integrating clinical, imaging, and genomic data to evaluate pathologic response, RFS, and their relationship and predictability based on tumor biomarkers. Patients and Methods Eligible patients had tumors ≥ 3 cm and received neoadjuvant chemotherapy. We determined associations between pathologic complete response (pCR; defined as the absence of invasive cancer in breast and nodes) and RFS, overall and within receptor subsets. Results In 221 evaluable patients (median tumor size, 6.0 cm; median age, 49 years; 91% classified as poor risk on the basis of the 70-gene prognosis profile), 41% were hormone receptor (HR) negative, and 31% were human epidermal gr...
369 citations
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TL;DR: A surprising new dimension to NO signaling is the direct cGMP-independent action of NO on channel proteins through S-nitrosylation, which expands the possibilities for modulating neuronal excitability.
368 citations
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TL;DR: Structural relationships (SAR) of the chalcones in the context of a homology-based model structure of the malaria trophozoite cysteine protease, the most likely target enzyme, are presented, suggesting that this series will be active against chloroquine-resistant malaria.
Abstract: A series of chalcones and their derivatives have been synthesized and identified as novel potential antimalarials using both molecular modeling and in vitro testing against the intact parasite. A large number of chalcones and their derivatives were prepared using one-step Claisen-Schmidt condensations of aldehydes with methyl ketones. These condensates were screened in vitro against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum and shown to be active at concentrations in the nanomolar range. The most active chalcone derivative, 1-(2,5-dichlorophenyl)-3-(4-quinolinyl)-2-propen-1-one (7), had an IC50 value of 200 nM against both a chloroquine-resistant strain (W2) and a chloroquine-sensitive strain (D6). The resistance indexes for all compounds were substantially lower than for chloroquine, suggesting that this series will be active against chloroquine-resistant malaria. Structure-activity relationships (SAR) of the chalcones in the context of a homology-based model structure of the malaria trophozoite cysteine protease, the most likely target enzyme, are presented.
368 citations
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TL;DR: In this paper, the authors validate self-reported self-reports of two major health conditions, hypertension and diabetes, based on a recently fielded survey in Taiwan (SEBAS, 2000), including both selfreported health information and a physical examination for a large, nationally representative sample of respondents aged 54 and older.
Abstract: Researchers and health specialists are increasingly obtaining information on chronic illnesses from self-reports. This study validates self-reports of two major health conditions, hypertension and diabetes, based on a recently fielded survey in Taiwan (SEBAS, 2000). The survey includes both self-reported health information and a physical examination for a large, nationally representative sample of respondents aged 54 and older. Average blood pressure readings, laboratory measures of glycosylated hemoglobin and information on whether the respondent was taking medication for hypertension or diabetes are used to validate respondents' reports of high blood pressure and diabetes. The resulting comparisons reveal that self-reports vastly underestimate the prevalence of hypertension (by almost 50 percent), but yield a reasonably accurate estimate of the prevalence of diabetes (a sensitivity of 83 percent). Significant correlates of the accuracy of the self-reports include age, education, time of the most recent health exam, and cognitive function.
367 citations
Authors
Showing all 23641 results
Name | H-index | Papers | Citations |
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Cyrus Cooper | 204 | 1869 | 206782 |
David Cella | 156 | 1258 | 106402 |
Carl H. June | 156 | 835 | 98904 |
Ichiro Kawachi | 149 | 1216 | 90282 |
Judy Garber | 147 | 756 | 79157 |
Bernard J. Gersh | 146 | 973 | 95875 |
Edward G. Lakatta | 146 | 858 | 88637 |
Eugene C. Butcher | 146 | 446 | 72849 |
Mark A. Rubin | 145 | 699 | 95640 |
Richard B. Devereux | 144 | 962 | 116403 |
Robert H. Purcell | 139 | 666 | 70366 |
Eric P. Winer | 139 | 751 | 71587 |
Richard L. Huganir | 137 | 425 | 61023 |
Rasmus Nielsen | 135 | 556 | 84898 |
Henry T. Lynch | 133 | 925 | 86270 |