Institution
Georgetown University
Education•Washington D.C., District of Columbia, United States•
About: Georgetown University is a education organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 23377 authors who have published 43718 publications receiving 1748598 citations. The organization is also known as: GU & Georgetown.
Topics: Population, Cancer, Breast cancer, Health care, Politics
Papers published on a yearly basis
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University of California, San Francisco1, Stanford University2, University of Alabama at Birmingham3, University of California, Los Angeles4, University of Melbourne5, Mayo Clinic6, Washington University in St. Louis7, Duke University8, Charité9, University of Massachusetts Medical School10, Harvard University11, Heidelberg University12, Georgetown University13, University of Münster14, National Institutes of Health15, University of Western Ontario16, University of Glasgow17, University of North Carolina at Chapel Hill18, University of Michigan19, University of Edinburgh20
TL;DR: Recommendations regarding the standardization of perfusion and penumbral imaging techniques, the validation of the accuracy and clinical utility of imaging markers of the ischemic penumbra, and the validate of imaging biomarkers relevant to clinical outcomes are summarized.
Abstract: The recent "Advanced Neuroimaging for Acute Stroke Treatment" meeting on September 7 and 8, 2007 in Washington DC, brought together stroke neurologists, neuroradiologists, emergency physicians, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), industry representatives, and members of the US Food and Drug Administration (FDA) to discuss the role of advanced neuroimaging in acute stroke treatment. The goals of the meeting were to assess state-of-the-art practice in terms of acute stroke imaging research and to propose specific recommendations regarding: (1) the standardization of perfusion and penumbral imaging techniques, (2) the validation of the accuracy and clinical utility of imaging markers of the ischemic penumbra, (3) the validation of imaging biomarkers relevant to clinical outcomes, and (4) the creation of a central repository to achieve these goals. The present article summarizes these recommendations and examines practical steps to achieve them.
387 citations
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Harvard University1, University of California, Los Angeles2, Curie Institute3, Université libre de Bruxelles4, Hebron University5, University of Pittsburgh6, Ohio State University7, Memorial Sloan Kettering Cancer Center8, Northside Hospital9, Georgetown University10, Baylor University Medical Center11, Jewish General Hospital12, Queen Mary University of London13, University of North Carolina at Chapel Hill14, University of California, San Francisco15
TL;DR: The Sacituzumab govitecan (SgoVitecan) is an antibody-drug conjugate composed of an antibody targeting the human tro... as mentioned in this paper.
Abstract: Background Patients with metastatic triple-negative breast cancer have a poor prognosis. Sacituzumab govitecan is an antibody–drug conjugate composed of an antibody targeting the human tro...
387 citations
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TL;DR: Age alone should not be a contraindication to the use of optimal chemotherapy regimens in older women who are in good general health, according to a retrospective review of data from 4 randomized trials.
Abstract: ContextAdjuvant chemotherapy improves survival for patients with local-regional
breast cancer, but healthy older patients at high risk of recurrence are frequently
not offered adjuvant chemotherapy, and the benefit of adjuvant chemotherapy
in older patients is uncertain.ObjectiveTo compare the benefits and toxic effects of adjuvant chemotherapy among
breast cancer patients in age groups of 50 years or younger, 51 to 64 years,
and 65 years or older.Design and SettingRetrospective review of data from 4 randomized trials that accrued patients
from academic and community medical centers between 1975 and 1999. Median
follow-up for all patients was 9.6 years. All trials randomized patients to
different regimens, doses, schedules, and durations of chemotherapy and all
had a treatment arm with doses or schedules that were regarded to be “high”
and potentially more toxic.PatientsA total of 6487 women with lymph node–positive breast cancer;
542 (8%) patients were 65 years or older and 159 (2%) were 70 years or older.Main Outcome MeasureComparison of disease-free survival, overall survival, and treatment-related
mortality among different age groups.ResultsMultivariate analysis showed that smaller tumor size, fewer positive
lymph nodes, more chemotherapy, and tamoxifen use were all significantly (P<.001) related to longer disease-free and overall survival.
There was no association between age and disease-free survival. Overall survival
was significantly (P<.001) worse for patients
aged 65 or older because of death from causes other than breast cancer. Thirty-three
deaths (0.5% of all patients) were attributed to treatment, and older women
had higher treatment-related mortality. Older women and younger women derived
similar reductions in breast cancer mortality and recurrence from regimens
containing more chemotherapy.ConclusionAge alone should not be a contraindication to the use of optimal chemotherapy
regimens in older women who are in good general health.
387 citations
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TL;DR: In this paper, the authors use insights from strategic management and organizational theory to suggest that organizational size may have an important impact on the extent of external learning, since it differentially affects the likelihood of learning via formal and informal mechanisms.
386 citations
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TL;DR: It is suggested that rather early in development synaptic receptors comprising NR1/NR2B subunits could be associated with other subunits so that blockade by haloperidol and CP101,606 is prevented.
Abstract: 1. Pharmacologically isolated miniature NMDA receptor-mediated excitatory postsynaptic currents (mN-EPSCs) were recorded in large visual cortical neurons in layer V of rat cortical slices. Haloperidol (100 microM) and CP101,606 (10 microM), two specific blockers of NMDA receptors comprising NR1/NR2B subunits, were tested on mN-EPSCs in rats at postnatal days 7 and 8 (P7-P8) and P13-P15. At both ages tested, no significant effects of these drugs were seen in the whole population of neurons, although in few neurons at both ages changes in amplitude were observed with haloperidol. Other dopamine receptor antagonists, spiperone and clozapine, failed to decrease mN-EPSCs in cortical neurons at P13-P15. 2. CP101,606 (10 microM) significantly decreased the amplitude of evoked N-EPSCs (eN-EPSCs) in visual cortical slices from rats at P3-P5, a developmental stage at which mRNA studies have indicated the virtual absence of NR2A mRNA. CP101,606 failed to significantly change evoked AMPA-mediated EPSCs at P5 and eN-EPSCs at P7-P8 and P13-P15. 3. NMDA receptor-mediated currents were also studied in somatic outside-out patches at P13-P15 with fast application of L-glutamate (1 mM). Haloperidol (50 microM) and CP101,606 (10 muM) blocked these currents in all patches tested. The effect of CP101,606 was concentration dependent. 4. We suggest that rather early in development synaptic receptors comprising NR1/NR2B subunits could be associated with other subunits so that blockade by haloperidol and CP101,606 is prevented. Moreover, the consistent blockade seen in outside out patches might be ascribed to the confinement of NR1/NR2B receptors to an extrasynaptic population.
386 citations
Authors
Showing all 23641 results
Name | H-index | Papers | Citations |
---|---|---|---|
Cyrus Cooper | 204 | 1869 | 206782 |
David Cella | 156 | 1258 | 106402 |
Carl H. June | 156 | 835 | 98904 |
Ichiro Kawachi | 149 | 1216 | 90282 |
Judy Garber | 147 | 756 | 79157 |
Bernard J. Gersh | 146 | 973 | 95875 |
Edward G. Lakatta | 146 | 858 | 88637 |
Eugene C. Butcher | 146 | 446 | 72849 |
Mark A. Rubin | 145 | 699 | 95640 |
Richard B. Devereux | 144 | 962 | 116403 |
Robert H. Purcell | 139 | 666 | 70366 |
Eric P. Winer | 139 | 751 | 71587 |
Richard L. Huganir | 137 | 425 | 61023 |
Rasmus Nielsen | 135 | 556 | 84898 |
Henry T. Lynch | 133 | 925 | 86270 |