Institution
Goethe University Frankfurt
Education•Frankfurt am Main, Hessen, Germany•
About: Goethe University Frankfurt is a education organization based out in Frankfurt am Main, Hessen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 33342 authors who have published 69743 publications receiving 2409538 citations. The organization is also known as: Johann Wolfgang Goethe-Universität Frankfurt am Main & University of Frankfurt am Main.
Topics: Population, Transplantation, Medicine, Context (language use), Cancer
Papers published on a yearly basis
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TL;DR: It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.
Abstract: The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer's disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.
382 citations
TL;DR: It is demonstrated that an acute down-regulation of parkin in human SH-SY5Y cells severely affects mitochondrial morphology and function, a phenotype comparable with that induced by PINK1 deficiency, and it is proposed that in mammals different strategies may have evolved to cope with dysfunctional mitochondria.
381 citations
Beth Israel Deaconess Medical Center1, Goethe University Frankfurt2, Praxis3, St George's, University of London4, State University of New York System5, Libin Cardiovascular Institute of Alberta6, Toho University7, University of Zaragoza8, University of California, San Diego9, Helsinki University Central Hospital10
TL;DR: A consensus guideline was prepared on behalf of the International Society for Holter and Noninvasive Electrocardiology and is cosponsored by the Japanese Circulation Society, the Computers in Cardiology Working Group on e-Cardiology of the European Society of Cardiology, and the European Cardiac Arrhythmia Society as mentioned in this paper.
381 citations
TL;DR: Despite the allogeneic nature of NK-92, development of human leukocyte antigen antibodies in these patients with cancer appears to be rare and some encouraging responses were seen in patients with advanced lung cancer.
381 citations
TL;DR: Results indicated that the D3 receptors participated in both dyskinesia and the therapeutic action of levodopa, and that partial agonists may normalize D3 receptor function and correct side effects of levidopa therapy in patients with Parkinson disease.
Abstract: In monkeys rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), expression of the dopamine D3 receptor was decreased. However, levodopa-induced dyskinesia (LID), similar to the debilitating and pharmacoresistant involuntary movements elicited after long-term treatment with levodopa in patients with Parkinson disease (PD), was associated with overexpression of this receptor. Administration of a D3 receptor-selective partial agonist strongly attenuated levodopa-induced dyskinesia, but left unaffected the therapeutic effect of levodopa. In contrast, attenuation of dyskinesia by D3 receptor antagonists was accompanied by the reappearance of PD-like symptoms. These results indicated that the D3 receptor participated in both dyskinesia and the therapeutic action of levodopa, and that partial agonists may normalize D3 receptor function and correct side effects of levodopa therapy in patients with PD.
381 citations
Authors
Showing all 33782 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jorge E. Cortes | 163 | 2784 | 124154 |
| Marc W. Kirschner | 162 | 457 | 102145 |
| Klaus Rajewsky | 154 | 504 | 88793 |
| Andreas Pfeiffer | 149 | 1756 | 131080 |
| Stefanie Dimmeler | 147 | 574 | 81658 |
| Hans Peter Beck | 143 | 1134 | 91858 |
| Gunther Roland | 141 | 1471 | 100681 |
| Ad Bax | 138 | 486 | 97112 |
| David G. Harrison | 137 | 492 | 72190 |
| Paul Brennan | 132 | 1221 | 72748 |
| Andreas M. Zeiher | 129 | 571 | 75125 |
| Jürgen Habermas | 126 | 503 | 114175 |
| Vincenzo Di Marzo | 126 | 659 | 60240 |
| Stuart J. Connolly | 125 | 610 | 75925 |
| James D. Griffin | 124 | 490 | 55565 |