Institution
Goethe University Frankfurt
Education•Frankfurt am Main, Hessen, Germany•
About: Goethe University Frankfurt is a education organization based out in Frankfurt am Main, Hessen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 33342 authors who have published 69743 publications receiving 2409538 citations. The organization is also known as: Johann Wolfgang Goethe-Universität Frankfurt am Main & University of Frankfurt am Main.
Topics: Population, Transplantation, Medicine, Context (language use), Cancer
Papers published on a yearly basis
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TL;DR: This communication provides practically useful resource tables and graphs on the new diagnostic criteria for JAK2/CALR/MPL mutation-related MPNs: PV, ET, and PMF and discusses the complementary role of mutation screening.
Abstract: The new edition of the 2016 World Health Organization (WHO) classification system for tumors of the hematopoietic and lymphoid tissues was published in September 2017. Under the category of myeloproliferative neoplasms (MPNs), the revised document includes seven subcategories: chronic myeloid leukemia, chronic neutrophilic leukemia, polycythemia vera (PV), primary myelofibrosis (PMF), essential thrombocythemia (ET), chronic eosinophilic leukemia-not otherwise specified and MPN, unclassifiable (MPN-U); of note, mastocytosis is no longer classified under the MPN category. In the current review, we focus on the diagnostic criteria for JAK2/CALR/MPL mutation-related MPNs: PV, ET, and PMF. In this regard, the 2016 changes were aimed at facilitating the distinction between masked PV and JAK2-mutated ET and between prefibrotic/early and overtly fibrotic PMF. In the current communication, we (i) provide practically useful resource tables and graphs on the new diagnostic criteria including outcome, (ii) elaborate on the rationale for the 2016 changes, (iii) discuss the complementary role of mutation screening, (iv) address ongoing controversies and propose solutions, (v) attend to the challenges of applying WHO criteria in routine clinical practice, and (vi) outline future directions from the perspectives of the clinical pathologist.
359 citations
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TL;DR: Dasatinib represents a safe and effective treatment option and an important therapeutic advance for patients with Ph-positive ALL and most adverse events were grade 1 or 2; febrile neutropenia was the most frequent severe AE, but this and other cytopenias were manageable with dose reduction.
359 citations
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TL;DR: Evidence is provided for a more detailed investigation of IVIgG for the treatment of AD as evidence for active or passive immunisation can mitigate plaque pathology in murine models of Alzheimer's disease.
Abstract: Objective: Active or passive immunisation can mitigate plaque pathology in murine models of Alzheimer’s disease (AD). Recently, it has been shown that antibodies against b-amyloid (Ab) are present in human immunoglobulin preparations (IVIgG), which specifically recognise and inhibit the neurotoxic effects of Ab. This study reports the results from a pilot study using IVIgG in patients with AD. Methods: Five patients with AD were enrolled and received monthly IVIgG over a 6 month period. Efficacy assessment included total Ab/Ab1–42 measured in the CSF/serum as well as effects on cognition (ADAS-cog; CERAD) at baseline and at 6 months following IVIgG. Results: Following IVIgG, total Ab levels in the CSF decreased by 30.1% (17.3–43.5%) compared to baseline (p,0.05). Total Ab increased in the serum by 233% (p,0.05). No significant change was found in Ab1–42 levels in the CSF/serum. Using ADAS-cog, an improvement of 3.7i2.9 points was detected. Scores in the MMSE were essentially unchanged (improved in four patients, stable in one patient) following IVIgG compared to baseline. Conclusion: Although the sample size of this pilot study is too small to draw a clear conclusion, the results of this pilot study provide evidence for a more detailed investigation of IVIgG for the treatment of AD.
359 citations
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TL;DR: With the exception of diterpenoid alkaloids (taxanes), Taxaceae contain terpenoids common in the other conifer families, and this supports their inclusion as a separate family in the major conifer clade.
Abstract: Chemosystematics is a common tool in systematics and taxonomy of extant plants. Terpenoids have been found to be especially valuable for chemosystematic investigations of conifers. A review of data in the extensive literature revealed some characteristic distribution patterns of sesqui-, di-, and triterpenoids in extant conifer families. The numerous terpenoids can be assigned to approximately 40 sesquiterpenoid, 17 diterpenoid, and only a few triterpenoid structural classes. Some of these terpenoid classes (e.g., cadinanes, humulanes, labdanes, pimaranes) are unspecific and distributed among all conifers. Other structural classes occur in certain clusters of families (e.g., totaranes in Podocarpaceae, Taxodiaceae, and Cupressaceae s.str.) or were restricted to species of only one conifer family (e.g., cuparanes in Cupressaceae s.str.).
359 citations
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Goethe University Frankfurt1, Siemens2, Bayer Schering Pharma AG3, Royal Hallamshire Hospital4, Bayer5, Dresden University of Technology6, University of Verona7, University of Göttingen8, Brigham and Women's Hospital9, Ludwig Maximilian University of Munich10, St James's University Hospital11, Bayer HealthCare Pharmaceuticals12, Humboldt State University13, University of Münster14, Université catholique de Louvain15
TL;DR: Gd-EOB-DTPA-enhanced MRI was superior in the diagnosis and therapeutic management of focal liver lesions compared with CT.
Abstract: A multicenter study has been employed to evaluate the diagnostic efficacy of magnetic resonance imaging (MRI) using the new liver-specific contrast agent gadoxetic acid (Gd-EOB-DTPA, Primovist), as opposed to contrast-enhanced biphasic spiral computed tomography (CT), in the diagnosis of focal liver lesions, compared with a standard of reference (SOR). One hundred and sixty-nine patients with hepatic lesions eligible for surgery underwent Gd-EOB-DTPA-enhanced MRI as well as CT within 6 weeks. Pathologic evaluation of the liver specimen combined with intraoperative ultrasound established the SOR. Data sets were evaluated on-site (14 investigators) and off-site (three independent blinded readers). Gd-EOB-DTPA was well tolerated. Three hundred and two lesions were detected in 131 patients valid for analysis by SOR. The frequency of correctly detected lesions was significantly higher on Gd-EOB-DTPA-enhanced MRI compared with CT in the clinical evaluation [10.44%; 95% confidence interval (CI): 4.88, 16.0]. In the blinded reading there was a trend towards Gd-EOB-DTPA-enhanced MRI, not reaching statistical significance (2.14%; 95% CI: -4.32, 8.6). However, the highest rate of correctly detected lesions with a diameter below 1 cm was achieved by Gd-EOB-DTPA-enhanced MRI. Differential diagnosis was superior for Gd-EOB-DTPA-enhanced MRI (82.1%) versus CT (71.0%). A change in surgical therapy was documented in 19 of 131 patients (14.5%) post Gd-EOB-DTPA-enhanced MRI. Gd-EOB-DTPA-enhanced MRI was superior in the diagnosis and therapeutic management of focal liver lesions compared with CT.
357 citations
Authors
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Name | H-index | Papers | Citations |
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Jorge E. Cortes | 163 | 2784 | 124154 |
Marc W. Kirschner | 162 | 457 | 102145 |
Klaus Rajewsky | 154 | 504 | 88793 |
Andreas Pfeiffer | 149 | 1756 | 131080 |
Stefanie Dimmeler | 147 | 574 | 81658 |
Hans Peter Beck | 143 | 1134 | 91858 |
Gunther Roland | 141 | 1471 | 100681 |
Ad Bax | 138 | 486 | 97112 |
David G. Harrison | 137 | 492 | 72190 |
Paul Brennan | 132 | 1221 | 72748 |
Andreas M. Zeiher | 129 | 571 | 75125 |
Jürgen Habermas | 126 | 503 | 114175 |
Vincenzo Di Marzo | 126 | 659 | 60240 |
Stuart J. Connolly | 125 | 610 | 75925 |
James D. Griffin | 124 | 490 | 55565 |