Indian Institute of Technology Ropar

About: Indian Institute of Technology Ropar is a education organization based out in Ropar, India. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 1014 authors who have published 2878 publications receiving 35715 citations.

Coupling of two asymmetric exclusion processes with open boundaries

Abstract: We study the dynamics of a coupled two-channel ASEP in which intra-channel transition rates are dependent on the configuration of neighboring channel. The binding constant k , which signifies the ratio of inter-channel transition rates, is introduced and the symmetric and asymmetric coupling conditions are analyzed for different values of k . The vertical cluster mean-field theory is used to study the system behavior exactly in strong coupling conditions and approximately in intermediate coupling conditions. Additionally, the consequences of particular dynamics such as totally asymmetric simple exclusion process (TASEP), partially asymmetric simple exclusion process (PASEP) and symmetric simple exclusion process (SSEP) in either one or both channels are investigated. It is found that the transition rates have a significant influence on both the qualitative and quantitative nature of the phase diagrams. The mathematical computation shows how the number of phases varies from 3 via 6 to 7 under different environments. Interestingly, in the fully asymmetric coupling case, the results are found to be independent of the magnitude of non-zero vertical transition rate. Our theoretical arguments are in well agreement with extensively performed Monte-Carlo simulation results.

Nano-aggregate-Fe3+ complex based on benzimidazole-modified calix[4]arene for amplified fluorescence detection of ADP in aqueous media

Abstract: In this study, a dipodal 2-(2-aminophenyl)benzimidazole scaffold appended to the lower rim of calix[4]arene at 1,3-alternate positions (L1) was synthesized. Organic nanoparticles of receptor L1 (O1) displayed remarkable selectivity and sensitivity for Fe3+ ions via a turn-off fluorescence response in an aqueous medium. The O1·Fe3+ complex was further studied for its binding ability toward biologically prevalent anions, and showed excellent selectivity for ADP in the nanomolar range, even in the presence of structurally similar nucleotides, with a blue shift and four-fold enhancement in the intensity of fluorescence emission. The determination of ADP is crucial because ADP plays significant roles in various biological reactions catalyzed by ATPases and kinases. ATP and ADP are also known to generate energy in cells via phosphate bond cleavage. The fluorescence quenching upon addition of Fe3+ ions could be attributed to the conglomeration of the nano-aggregates, which either separated or further assembled when ADP was added to the ensemble. Consequently, the fluorescence of the ensemble could be recovered. The sensing system was also applied to the detection of ADP in spiked blood serum samples; the excellent recovery of up to 99.3% validated its practicality. The off-on sensing mode, simple fabrication process, and ease of synthetic methodology are some of the advantages for further applications. The sensor was also successfully applied to monitoring of the hydrolysis of ADP to AMP by apyrase, which indicated its potential application for ADP-pertinent biological activities.

Cuffless BP measurement using a correlation study of pulse transient time and heart rate.

Abstract: The recent advancements in computing, signal processing and communication technologies have immensely improved public health care systems. As a result, new diagnostic instruments with better precision and compatibility with machines, gadgets and databases are developed. However, many of these technical marvels are young and still at research level, and are not very well known commercially. In the present study, a cuff-less blood pressure (BP) measurement was done using correlation study of pulse transient time and heart rate. Among the various vital biomedical signals that can be collected non-invasively, Electrocardiogram (ECG) and Photoplethysmograph (PPG) were taken simultaneously to determine electrical signals of the heart (ECG), the condition of the arteries (PPG) and together can be related to the arterial pressure of the systemic circulation (BP). This promises to give a composite overview of the cardiovascular system non-invasively. The BP estimation was done using non-linear 2nd order curve fitting regression model. The final objective is to develop a portable, non-invasive, biomedical signal acquisition system which not only can monitor, store and communicate the above mentioned biomedical signals but can also predict the BP by processing these signals. The device will be used for continuous monitoring especially for patients with cardiovascular complaints, and will be reduced to a mobile attachment, that is easy to use and can be operated by a paramedical staff (ASHA workers) with minimal training.