Indian Institute of Technology Ropar

About: Indian Institute of Technology Ropar is a education organization based out in Ropar, India. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 1014 authors who have published 2878 publications receiving 35715 citations.

Lysozyme Complexes for the Synthesis of Functionalized Biomaterials To Understand Protein–Protein Interactions and Their Biological Applications

Abstract: Interactions between the components of lysozyme/cytochrome c (lysozyme/Cyt,c) and lysozyme/zein protein mixtures were determined by following the in vitro synthesis of gold (Au) nanoparticles (NPs). Both UV–visible and fluorescence studies were employed to monitor the interactions and simultaneous synthesis of protein coated NPs. Protein coated NPs were characterized by gel electrophoresis and TEM studies. Lysozyme/Cyt,c complex coated NPs showed remarkable pH responsive behavior due to their amphiphilic nature, while lysozyme/zein complex coated NPs were not pH sensitive because of the predominantly hydrophobic nature. The results were further supported by molecular dynamics studies (MD) of protein–protein interactions and interactions of protein with the gold surface. Molecular simulations helped us to identify the amino acids that drove such interactions. Biological applications of protein coated NPs were determined from hemolytic and antimicrobial studies to demonstrate their potential in pharmaceutic...

Facet-controlled morphology of cobalt disulfide towards enhanced oxygen reduction reaction

Abstract: Catalytic activity has a significant contribution from exposed facets which are prominently correlated with morphology. It has been witnessed that even a small refinement in morphology alters the catalytic activity over several folds which is a key towards catalyst design. The present study thereby explores the design of octahedral CoS2 crystals with the aim of exposing highly active facets for the oxygen reduction reaction (ORR) which were carefully synthesized to incorporate carbon inherently. One-pot hydrothermal synthesis was employed using trisodium citrate and sodium thiosulfate. The resultant crystals of octahedral CoS2 with exposed {111} and {220} planes were revealed by HR-TEM and XRD studies. Detailed structure–activity insight regarding ORR was obtained using rotating ring disk electrode and electrochemical quartz crystal microbalance (EQCM) analysis and facet controlled octahedral CoS2 was shown to have the 50 fold increase in activity relative to other variants in an acidic medium and is comparable to a state-of-the-art Pt/C (20%) catalyst. The local catalytic activity of the CoS2 catalyst was visualized by the redox-competition mode of scanning electrochemical microscopy (RC-SECM).

Design and syntheses of novel fluorescent organosilicon-based chemosensors through click silylation: detection of biogenic amines

Abstract: A concise and useful synthesis of novel 1,2,3-triazole based silatrane (TBS)-scaffolds (2a–e) in good yield from 1,2,3-triazole based triethoxysilane (TBTES)-linkers (1a–e) is described. Click silylation of terminal alkynes with γ-azidopropyltriethoxysilane (AzPTES) was used for the synthesis of TBTES-linkers (1a–e). The synthesized TBS-scaffolds (2a–e) were comprehensively characterized by 1H and 13C NMR, mass spectrometry and single X-ray crystallographic studies. The broad scope of these TBS-scaffolds towards biogenic amines is explored by the use of a CH3CN : H2O (98 : 2; v/v) solvent system. The receptor 2c and 2d shows high affinity towards spermine and histamine, respectively. To the best of our knowledge, the present investigation represents the first report on the use of organosilicon-based chemosensors for the recognition of biogenic amines.