Institution
Jilin University
Education•Changchun, China•
About: Jilin University is a education organization based out in Changchun, China. It is known for research contribution in the topics: Catalysis & Apoptosis. The organization has 101453 authors who have published 88966 publications receiving 1444456 citations. The organization is also known as: Jílín Dàxué.
Topics: Catalysis, Apoptosis, Cancer, Adsorption, Cell growth
Papers published on a yearly basis
Papers
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TL;DR: Analysis and simulation results for a two-degree-of-freedom (2-DOF) quarter-car model show possible improvements on ride comfort, while respecting time-domain hard constraints.
Abstract: This paper suggests a constrained H/sub /spl infin// control scheme for active suspensions with output and control constraints. The H/sub /spl infin// performance is used to measure ride comfort so that more general road disturbances can be considered. Time-domain constraints, representing requirements for: 1) good road holding which may have an impact on safety; 2) suspension stroke limitation; and 3) avoidance of actuator saturation, are captured using the concept of reachable sets and state-space ellipsoids. The proposed approach can potentially achieve the best possible ride comfort by allowing constrained variables free as long as they remain within given bounds. A state feedback solution to the constrained H/sub /spl infin// active suspension control problem is derived in the framework of linear matrix inequality (LMI) optimization and multiobjective control. Analysis and simulation results for a two-degree-of-freedom (2-DOF) quarter-car model show possible improvements on ride comfort, while respecting time-domain hard constraints.
276 citations
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TL;DR: Recent clinical and preclinical studies that outline the role of TIBs in lung cancer development, assess their prognostic significance, and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment are reviewed.
Abstract: Evidence indicates that lung cancer development is a complex process that involves interactions between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating immune cells play a significant role in the promotion or inhibition of tumor growth. As an integral component of the tumor microenvironment, tumor-infiltrating B lymphocytes (TIBs) exist in all stages of cancer and play important roles in shaping tumor development. Here, we review recent clinical and preclinical studies that outline the role of TIBs in lung cancer development, assess their prognostic significance, and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment.
275 citations
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TL;DR: A simple method for the preparation of combinatorial drug-loaded cubosomes with, proof-of-principle, therapeutic effect against cancer cells, along with diagnostic capabilities, was described.
Abstract: Cubosomes, a product of nanobioengineering, are self-structured lipid nanoparticles that act like drug-loaded theranostic probes. Here, we describe a simple method for the preparation of combinatorial drug-loaded cubosomes with, proof-of-principle, therapeutic effect against cancer cells, along with diagnostic capabilities. Anticancer drugs cisplatin and paclitaxel were loaded in the cubosomes in combination. The cubosomes were coated with a layer of poly-Ɛ-lysine, which helped avoid the initial burst release of drug and allowed for a slow and sustained release for better efficacy. Cubosomes were imaged by transmission electron microscope, and their dispersion analyzed in vitro by differential scanning calorimetric and X-ray diffractogram studies. The microscopic images depicted spherical polyangular structures, which are easily distinguishable. The analyses revealed that the drug is uniformly dispersed all through the cubosomes. Further characterization was carried out by zeta-potential measurement, in vitro release, and entrapment efficiency studies. The in vitro studies established that the coating of cubosomes successfully reduced the burst release of drugs initially and confirmed a slow, sustained release over increased time. Comparative cytotoxicity of coated, uncoated, and blank cubosomes was evaluated, using human hepatoma HepG2 cell line, and the formulations were found to be entirely nontoxic, similar to the blank ones. The therapeutic efficiency of the cubosomes against HeLa cells was confirmed by the impedance measurement and fluorescent imaging. Furthermore, the reduction in impedance in cells treated with coated combinatorial cubosomes proved the impairment of HeLa cells, as confirmed by fluorescence microscopy.
275 citations
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TL;DR: Low-cost copper-amine complex was rationally designed to be a novel template for one-pot synthesis of Cu-SSZ-13 zeolites and exhibits superior catalytic performance on NH(3)-SCR reaction.
274 citations
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TL;DR: The BChE-ATCh-MnO2-CDs system can be utilized to detect OPs quantitatively based on the fluorescence turn "on-off", and the proposed assay can potentially be a candidate for OPs detection.
Abstract: Carbon dots (CDs) combined with a nanomaterial-based quencher has created an innovative way for designing promising sensors. Herein, a novel fluorescent-sensing platform was designed for sensitive detection of organophosphorus pesticides (OPs). The preparation of CDs was based on one-step hydrothermal reaction of 3-aminobenzeneboronic acid. The fluorescence of CDs can be quenched by manganese dioxide (MnO2) nanosheets via the Forster resonance energy transfer (FRET). In the presence of butyrylcholinesterase (BChE) and acetylthiocholine, the enzymatic hydrolysate (thiocholine) can efficiently trigger the decomposition of MnO2 nanosheets, resulting in the recovery of CDs fluorescence. OPs as inhibitors for BChE activity can prevent the generation of thiocholine and decomposition of MnO2 nanosheets, accompanying the fluorescence “turn-off” of the system. So the BChE-ATCh-MnO2–CDs system can be utilized to detect OPs quantitatively based on the fluorescence turn “on–off”. Under the optimum conditions, the pre...
274 citations
Authors
Showing all 101943 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yang Yang | 171 | 2644 | 153049 |
Yury Gogotsi | 171 | 956 | 144520 |
Lei Jiang | 170 | 2244 | 135205 |
Gang Chen | 167 | 3372 | 149819 |
Dongyuan Zhao | 160 | 872 | 106451 |
Rui Zhang | 151 | 2625 | 107917 |
Xiaodong Wang | 135 | 1573 | 117552 |
Avelino Corma | 134 | 1049 | 89095 |
Jie Liu | 131 | 1531 | 68891 |
Shuai Liu | 129 | 1095 | 80823 |
Yang Liu | 129 | 2506 | 122380 |
Sheng Dai | 122 | 985 | 63472 |
Xin Wang | 121 | 1503 | 64930 |
Simon A. Wilde | 118 | 390 | 45547 |
Shaojun Dong | 118 | 873 | 57337 |