Institution
Jilin University
Education•Changchun, China•
About: Jilin University is a education organization based out in Changchun, China. It is known for research contribution in the topics: Catalysis & Apoptosis. The organization has 101453 authors who have published 88966 publications receiving 1444456 citations. The organization is also known as: Jílín Dàxué.
Topics: Catalysis, Apoptosis, Cancer, Adsorption, Cell growth
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the ages of two highly evolved granitic plutons, Woduhe and Baerzhe, from the Great Xing'an Mountains were constrained at 130±4 Ma for the Wodahe and 122±5 Ma for BaerZhe granites by Rb-Sr and Sm-Nd isotope analyses.
439 citations
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TL;DR: The potential applications of aptamer technology as a new tool for targeted cancer therapy with emphasis on the development of aptamers that are able to specifically target cell surface biomarkers are discussed.
Abstract: Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar to antibodies, aptamers interact with their targets by recognizing a specific three-dimensional structure and are thus termed “chemical antibodies.” In contrast to protein antibodies, aptamers offer unique chemical and biological characteristics based on their oligonucleotide properties. Hence, they are more suitable for the development of novel clinical applications. Aptamer technology has been widely investigated in various biomedical fields for biomarker discovery, in vitro diagnosis, in vivo imaging, and targeted therapy. This review will discuss the potential applications of aptamer technology as a new tool for targeted cancer therapy with emphasis on the development of aptamers that are able to specifically target cell surface biomarkers. Additionally, we will describe several approaches for the use of aptamers in targeted therapeutics, including aptamer-drug conjugation, aptamer-nanoparticle conjugation, aptamer-mediated targeted gene therapy, aptamer-mediated immunotherapy, and aptamer-mediated biotherapy.
439 citations
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TL;DR: In this paper, the authors report the fabrication of a self-assembled 3D films platform that combines a natural viscoelastic property material P(VDF-TrFe) with an electrically conductive material rGO for the first time.
434 citations
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TL;DR: Recent developments are highlighted for MOFs participating as catalysts for the chemical fixation and photochemical reduction of CO2 .
Abstract: Carbon dioxide (CO2 ), as the primary greenhouse gas in the atmosphere, triggers a series of environmental and energy related problems in the world. Therefore, there is an urgent need to develop multiple methods to capture and convert CO2 into useful chemical products, which can significantly improve the environment and promote sustainable development. Over the past several decades, metal-organic frameworks (MOFs) have shown outstanding heterogeneous catalytic activity due in part to their high internal surface area and chemical functionalities. These properties and the ability to synthesize MOF platforms allow experiments to test structure-function relationships for transforming CO2 into useful chemicals. Herein, recent developments are highlighted for MOFs participating as catalysts for the chemical fixation and photochemical reduction of CO2 . Finally, opportunities and challenges facing MOF catalysts are discussed in this ongoing research area.
433 citations
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TL;DR: A surface plasmon resonance sensor based on two-dimensional nanomaterial of antimonene for the specific label-free detection of clinically relevant biomarkers such as miRNA-21 and mi RNA-155 and provides a promising avenue for the early diagnosis, staging, and monitoring of cancer.
Abstract: MicroRNA exhibits differential expression levels in cancer and can affect cellular transformation, carcinogenesis and metastasis. Although fluorescence techniques using dye molecule labels have been studied, label-free molecular-level quantification of miRNA is extremely challenging. We developed a surface plasmon resonance sensor based on two-dimensional nanomaterial of antimonene for the specific label-free detection of clinically relevant biomarkers such as miRNA-21 and miRNA-155. First-principles energetic calculations reveal that antimonene has substantially stronger interaction with ssDNA than the graphene that has been previously used in DNA molecule sensing, due to thanking for more delocalized 5s/5p orbitals in antimonene. The detection limit can reach 10 aM, which is 2.3-10,000 times higher than those of existing miRNA sensors. The combination of not-attempted-before exotic sensing material and SPR architecture represents an approach to unlocking the ultrasensitive detection of miRNA and DNA and provides a promising avenue for the early diagnosis, staging, and monitoring of cancer.
432 citations
Authors
Showing all 101943 results
Name | H-index | Papers | Citations |
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Yang Yang | 171 | 2644 | 153049 |
Yury Gogotsi | 171 | 956 | 144520 |
Lei Jiang | 170 | 2244 | 135205 |
Gang Chen | 167 | 3372 | 149819 |
Dongyuan Zhao | 160 | 872 | 106451 |
Rui Zhang | 151 | 2625 | 107917 |
Xiaodong Wang | 135 | 1573 | 117552 |
Avelino Corma | 134 | 1049 | 89095 |
Jie Liu | 131 | 1531 | 68891 |
Shuai Liu | 129 | 1095 | 80823 |
Yang Liu | 129 | 2506 | 122380 |
Sheng Dai | 122 | 985 | 63472 |
Xin Wang | 121 | 1503 | 64930 |
Simon A. Wilde | 118 | 390 | 45547 |
Shaojun Dong | 118 | 873 | 57337 |