Jilin University

About: Jilin University is a education organization based out in Changchun, China. It is known for research contribution in the topics: Catalysis & Apoptosis. The organization has 101453 authors who have published 88966 publications receiving 1444456 citations. The organization is also known as: Jílín Dàxué.

Organic Light‐Emitting Diodes Using a Neutral π Radical as Emitter: The Emission from a Doublet

Abstract: Triplet harvesting is a main challenge in organic light-emitting devices (OLEDs), because the radiative decay of the triplet is spin-forbidden. Here, we propose a new kind of OLED, in which an organic open-shell molecule, (4-N-carbazolyl-2,6-dichlorophenyl)bis(2,4,6-trichlorophenyl)methyl (TTM-1Cz) radical, is used as an emitter, to circumvent the transition problem of triplet. For TTM-1Cz, there is only one unpaired electron in the highest singly occupied molecular orbital (SOMO). When this electron is excited to the lowest singly unoccupied molecular orbital (SUMO), the SOMO is empty. Thus, transition back of the excited electron to the SOMO is totally spin-allowed. Spectral analysis showed that electroluminescence of the OLED originated from the electron transition between SUMO and SOMO. The magneto-electroluminescence measurements revealed that the spin configuration of the excited state of TTM-1Cz is a doublet. Our results pave a new way to obtain 100 % internal quantum efficiency of OLEDs.

Vitamin C modulates TET1 function during somatic cell reprogramming

Abstract: Vitamin C, a micronutrient known for its anti-scurvy activity in humans, promotes the generation of induced pluripotent stem cells (iPSCs) through the activity of histone demethylating dioxygenases. TET hydroxylases are also dioxygenases implicated in active DNA demethylation. Here we report that TET1 either positively or negatively regulates somatic cell reprogramming depending on the absence or presence of vitamin C. TET1 deficiency enhances reprogramming, and its overexpression impairs reprogramming in the context of vitamin C by modulating the obligatory mesenchymal-to-epithelial transition (MET). In the absence of vitamin C, TET1 promotes somatic cell reprogramming independent of MET. Consistently, TET1 regulates 5-hydroxymethylcytosine (5hmC) formation at loci critical for MET in a vitamin C-dependent fashion. Our findings suggest that vitamin C has a vital role in determining the biological outcome of TET1 function at the cellular level. Given its benefit to human health, vitamin C should be investigated further for its role in epigenetic regulation.