Jilin University

About: Jilin University is a education organization based out in Changchun, China. It is known for research contribution in the topics: Catalysis & Apoptosis. The organization has 101453 authors who have published 88966 publications receiving 1444456 citations. The organization is also known as: Jílín Dàxué.

Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial.

Abstract: Importance Although the benefit of reducing blood pressure for primary and secondary prevention of stroke has been established, the effect of antihypertensive treatment in patients with acute ischemic stroke is uncertain. Objective To evaluate whether immediate blood pressure reduction in patients with acute ischemic stroke would reduce death and major disability at 14 days or hospital discharge. Design, Setting, and Participants The China Antihypertensive Trial in Acute Ischemic Stroke, a single-blind, blinded end-points randomized clinical trial, conducted among 4071 patients with nonthrombolysed ischemic stroke within 48 hours of onset and elevated systolic blood pressure. Patients were recruited from 26 hospitals across China between August 2009 and May 2013. Interventions Patients (n = 2038) were randomly assigned to receive antihypertensive treatment (aimed at lowering systolic blood pressure by 10% to 25% within the first 24 hours after randomization, achieving blood pressure less than 140/90 mm Hg within 7 days, and maintaining this level during hospitalization) or to discontinue all antihypertensive medications (control) during hospitalization (n = 2033). Main Outcomes and Measures Primary outcome was a combination of death and major disability (modified Rankin Scale score ≥3) at 14 days or hospital discharge. Results Mean systolic blood pressure was reduced from 166.7 mm Hg to 144.7 mm Hg (−12.7%) within 24 hours in the antihypertensive treatment group and from 165.6 mm Hg to 152.9 mm Hg (−7.2%) in the control group within 24 hours after randomization (difference, −5.5% [95% CI, −4.9 to −6.1%]; absolute difference, −9.1 mm Hg [95% CI, −10.2 to −8.1]; P P P = .98) at 14 days or hospital discharge. The secondary composite outcome of death and major disability at 3-month posttreatment follow-up did not differ between treatment groups (500 events [antihypertensive treatment] vs 502 events [control]; odds ratio, 0.99 [95% CI, 0.86 to 1.15]; P = .93). Conclusion and Relevance Among patients with acute ischemic stroke, blood pressure reduction with antihypertensive medications, compared with the absence of hypertensive medication, did not reduce the likelihood of death and major disability at 14 days or hospital discharge. Trial Registration clinicaltrials.gov Identifier:NCT01840072

Cloud Task Scheduling Based on Load Balancing Ant Colony Optimization

Abstract: The cloud computing is the development of distributed computing, parallel computing and grid computing, or defined as the commercial implementation of these computer science concepts. One of the fundamental issues in this environment is related to task scheduling. Cloud task scheduling is an NP-hard optimization problem, and many meta-heuristic algorithms have been proposed to solve it. A good task scheduler should adapt its scheduling strategy to the changing environment and the types of tasks. This paper proposes a cloud task scheduling policy based on Load Balancing Ant Colony Optimization (LBACO) algorithm. The main contribution of our work is to balance the entire system load while trying to minimizing the make span of a given tasks set. The new scheduling strategy was simulated using the CloudSim toolkit package. Experiments results showed the proposed LBACO algorithm outperformed FCFS (First Come First Serve) and the basic ACO (Ant Colony Optimization).

Large Intervening Non-Coding RNA HOTAIR is Associated with Hepatocellular Carcinoma Progression

Abstract: Increasing evidence suggests that large intervening non-coding RNAs (lincRNAs) regulate key pathways in cancer invasion and metastasis. In this observational retrospective study, the expression of the oncogenic lincRNA HOX transcript antisense RNA (HOTAIR) gene was measured in 63 patients with hepatocellular carcinoma (HCC) following hepatic resection. The HOTAIR gene was significantly overexpressed in HCC tissues compared with adjacent non-tumour tissues. Patients with high HOTAIR gene expression in their tumours had an increased risk of recurrence after hepatectomy. There was also a significant correlation between HOTAIR expression and lymph node metastasis. In vitro assays in the HCC cell line Bel7402 demonstrated that knockdown of HOTAIR lincRNA reduced cell proliferation and was associated with reductions in levels of matrix metalloproteinase-9 and vascular endothelial growth factor protein, which are important for cell motility and metastasis. In conclusion, HOTAIR lincRNA might be a potential bioma...

Corrosion engineering towards efficient oxygen evolution electrodes with stable catalytic activity for over 6000 hours

Abstract: Although a number of nonprecious materials can exhibit catalytic activity approaching (sometimes even outperforming) that of iridium oxide catalysts for the oxygen evolution reaction, their catalytic lifetimes rarely exceed more than several hundred hours under operating conditions. Here we develop an energy-efficient, cost-effective, scaled-up corrosion engineering method for transforming inexpensive iron substrates (e.g., iron plate and iron foam) into highly active and ultrastable electrodes for oxygen evolution reaction. This synthetic method is achieved via a desired corrosion reaction of iron substrates with oxygen in aqueous solutions containing divalent cations (e.g., nickel) at ambient temperature. This process results in the growth on iron substrates of thin film nanosheet arrays that consist of iron-containing layered double hydroxides, instead of rust. This inexpensive and simple manufacturing technique affords iron-substrate-derived electrodes possessing excellent catalytic activities and activity retention for over 6000 hours at 1000 mA cm-2 current densities.