Konkuk University

About: Konkuk University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Apoptosis. The organization has 13405 authors who have published 27027 publications receiving 506313 citations.

Direct reprogramming of fibroblasts into epiblast stem cells

Abstract: The four transcription factors Oct4, Sox2, Klf4 and c-myc induce somatic cells to reprogramme to an early embryonic stem cell state. When expressed in somatic cells under culture conditions that are normally used for stem cells derived from mouse epiblast tissue of post-implantation embryos (EpiSCs), these factors drive reprogramming to a state that closely resembles EpiSCs, highlighting the importance of culture environment in determining the outcome of reprogramming.

Final tau-neutrino results from the DONuT experiment

Abstract: The DONuT experiment collected data in 1997 and published first results in 2000 based on four observed ${\ensuremath{ u}}_{\ensuremath{\tau}}$ charged-current (CC) interactions. The final analysis of the data collected in the experiment is presented in this paper, based on $3.6\ifmmode\times\else\texttimes\fi{}{10}^{17}$ protons on target using the 800 GeV Tevatron beam at Fermilab. The number of observed ${\ensuremath{ u}}_{\ensuremath{\tau}}$ CC events is 9 with an estimated background of 1.5 events, from a total of 578 observed neutrino interactions. We calculate the ${\ensuremath{ u}}_{\ensuremath{\tau}}$ CC cross section as a function of one parameter. Assuming ${\mathrm{D}}_{\mathrm{s}}$ mesons are the sole source for ${\ensuremath{ u}}_{\ensuremath{\tau}}$, the energy-independent part of the total CC cross section can be parametrized as ${\ensuremath{\sigma}}^{\mathrm{const}}({\ensuremath{ u}}_{\ensuremath{\tau}})=2.51{n}^{1.52}\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}40}\text{ }\text{ }{\mathrm{cm}}^{2}\text{ }{\mathrm{GeV}}^{\ensuremath{-}1}$ for $n\ensuremath{\ge}4$, where $n$ is the parameter controlling the longitudinal part of the ${\mathrm{D}}_{\mathrm{s}}$ differential cross section of the form $d\ensuremath{\sigma}/d{x}_{F}\ensuremath{\propto}(1\ensuremath{-}|{x}_{F}|{)}^{n}$. The analysis could not distinguish between ${\ensuremath{ u}}_{\ensuremath{\tau}}$ and ${\overline{\ensuremath{ u}}}_{\ensuremath{\tau}}$. The value of $n$ obtained from Pythia simulations, $n=6.1$, gives an estimated value of ${\ensuremath{\sigma}}^{\mathrm{const}}({\ensuremath{ u}}_{\ensuremath{\tau}})=(0.39\ifmmode\pm\else\textpm\fi{}0.13\ifmmode\pm\else\textpm\fi{}0.13)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}38}\text{ }\text{ }{\mathrm{cm}}^{2}\text{ }{\mathrm{GeV}}^{\ensuremath{-}1}$.

Gadolinium Deposition in the Brain: Current Updates.

Abstract: Gadolinium-based contrast agents (GBCAs) are commonly used for enhancement in MR imaging and have long been considered safe when administered at recommended doses. However, since the report that nephrogenic systemic fibrosis is linked to the use of GBCAs in subjects with severe renal diseases, accumulating evidence has suggested that GBCAs are not cleared entirely from our bodies; some GBCAs are deposited in our tissues, including the brain. GBCA deposition in the brain is mostly linked to the specific chelate structure of the GBCA: linear GBCAs were responsible for brain deposition in almost all reported studies. This review aimed to summarize the current knowledge about GBCA brain deposition and discuss its clinical implications.