Institution
Konkuk University
Education•Seoul, South Korea•
About: Konkuk University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Apoptosis. The organization has 13405 authors who have published 27027 publications receiving 506313 citations.
Topics: Population, Apoptosis, Cancer, Graphene, Cancer cell
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that FBMS may have beneficial effects on hypertension after blood pressure significantly decreased after peptide ingestion.
161 citations
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TL;DR: This review describes and discusses recent results about the direct interactions of polyphenols and protein kinases in cancer chemoprevention.
161 citations
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Yonsei University1, University of Maryland, College Park2, Ewha Womans University3, Pusan National University4, Seoul National University5, Pukyong National University6, Gwangju Institute of Science and Technology7, Gangneung–Wonju National University8, Kyungpook National University9, Ulsan National Institute of Science and Technology10, Goddard Space Flight Center11, Harvard University12, Langley Research Center13, European Space Research and Technology Centre14, Korea Aerospace Research Institute15, Konkuk University16, National Institute of Environmental Research17, Royal Netherlands Meteorological Institute18, National Center for Atmospheric Research19, Chiba University20, Nara Women's University21, Japan Agency for Marine-Earth Science and Technology22, University of Science and Technology of China23, Peking University24, University of Iowa25, University of Alabama in Huntsville26, NASA Headquarters27, University of Maryland, Baltimore County28, Hong Kong University of Science and Technology29, California Institute of Technology30, EUMETSAT31, York University32, University of Houston33
TL;DR: The Geostationary Environment Monitoring Spectrometer (GEMS) is scheduled for launch in February 2020 to monitor air quality (AQ) at an unprecedented spatial and temporal resolution from a...
Abstract: The Geostationary Environment Monitoring Spectrometer (GEMS) is scheduled for launch in February 2020 to monitor air quality (AQ) at an unprecedented spatial and temporal resolution from a ...
161 citations
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TL;DR: The results suggest that prenatally VPA‐exposed rats show the male preponderance of ASD‐like behaviors including defective social interaction similar to human autistic patients, which might be caused by ectopic increase in glutamatergic synapses in male rats.
Abstract: Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by three main behavioral symptoms including social deficits, impaired communication, and stereotyped and repetitive behaviors. ASD prevalence shows gender bias to male. Prenatal exposure to valproic acid (VPA), a drug used in epilepsy and bipolar disorder, induces autistic symptoms in both human and rodents. As we reported previously, prenatally VPA-exposed animals at E12 showed impairment in social behavior without any overt reproductive toxicity. Social interactions were not significantly different between male and female rats in control condition. However, VPA-exposed male offspring showed significantly impaired social interaction while female offspring showed only marginal deficits in social interaction. Similar male inclination was observed in hyperactivity behavior induced by VPA. In addition to the ASD-like behavioral phenotype, prenatally VPA-exposed rat offspring shows crooked tail phenotype, which was not different between male and female groups. Both male and female rat showed reduced GABAergic neuronal marker GAD and increased glutamatergic neuronal marker vGluT1 expression. Interestingly, despite of the similar increased expression of vGluT1, post-synaptic marker proteins such as PSD-95 and α-CAMKII expression was significantly elevated only in male offspring. Electron microscopy showed increased number of post-synapse in male but not in female at 4 weeks of age. These results might suggest that the altered glutamatergic neuronal differentiation leads to deranged post-synaptic maturation only in male offspring prenatally exposed to VPA. Consistent with the increased post-synaptic compartment, VPA-exposed male rats showed higher sensitivity to electric shock than VPA-exposed female rats. These results suggest that prenatally VPA-exposed rats show the male preponderance of ASD-like behaviors including defective social interaction similar to human autistic patients, which might be caused by ectopic increase in glutamatergic synapses in male rats.
161 citations
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TL;DR: This review describes the morphological and molecular aspects of various IR-induced types of cell death and proposes radiation-sensitization strategies that can counteract the resistance of tumors to IR.
Abstract: Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence. Among them, apoptosis and mitotic catastrophe are the main mechanisms of IR action. DNA damage and genomic instability contribute to IR-induced cancer cell death. Although IR therapy may be curative in a number of cancer types, the resistance of cancer cells to radiation remains a major therapeutic problem. In this review, we describe the morphological and molecular aspects of various IR-induced types of cell death. We also discuss cytogenetic variations representative of IR-induced DNA damage and genomic instability. Most importantly, we focus on several pathways and their associated marker proteins responsible for cancer resistance and its therapeutic implications in terms of cancer cell death of various types and characteristics. Finally, we propose radiation-sensitization strategies, such as the modification of fractionation, inflammation, and hypoxia and the combined treatment, that can counteract the resistance of tumors to IR.
161 citations
Authors
Showing all 13470 results
Name | H-index | Papers | Citations |
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Richard A. Flavell | 231 | 1328 | 205119 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Jovan Milosevic | 152 | 1433 | 106802 |
Jongmin Lee | 150 | 2257 | 134772 |
Byung-Sik Hong | 146 | 1557 | 105696 |
Ali Khademhosseini | 140 | 887 | 76430 |
Suyong Choi | 135 | 1495 | 97053 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Maurizio Fava | 126 | 1012 | 70636 |
Mihee Jo | 125 | 806 | 68740 |
Dooyeon Gyun | 122 | 836 | 67653 |
Dong Ho Moon | 119 | 912 | 67053 |
Sanghyeon Song | 119 | 556 | 56460 |
Louis J. Ignarro | 106 | 335 | 46008 |
Hans R. Schöler | 95 | 374 | 41150 |