LAC+USC Medical Center

About: LAC+USC Medical Center is a healthcare organization based out in Los Angeles, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 1348 authors who have published 886 publications receiving 21927 citations. The organization is also known as: County/USC & Los Angeles County General.

Is your graduating general surgery resident qualified to take trauma call? A 15-year appraisal of the changes in general surgery education for trauma.

Abstract: BACKGROUNDTrauma training in general surgery residency is undergoing an evolution. Hour restrictions, the growth of subspecialty care, and the trend toward nonoperative management have altered resident exposure to operative trauma. We sought to identify trends in resident trauma training since the i

Effect of fenfluramine on sympathetic firing rate.

Abstract: The effects of acute and chronic treatment with fenfluramine have been explored in two experiments. Three and twenty-four hours following the injection of fenfluramine 20 mg/kg the firing rate of sympathetic efferent nerves to brown adipose tissue was significantly increased compared to sham injected controls. Body weight loss following acute treatment with fenfluramine was significantly greater at three and twenty-four hours than in the vehicle-treated controls. In the chronic experiment animals were treated once daily for 12 days with 20 mg/kg of fenfluramine. There were two control groups. One control group ate ad lib and a second control group was pair fed to maintain body weight comparable to that of the fenfluramine-treated animals. By the twelfth day food intake in the fenfluramine-treated animals had returned to control levels. Sympathetic firing rate after three days of treatment with fenfluramine was significantly higher in the treated animals than in ad lib fed controls. The ad lib fed controls were likewise significantly higher than the vehicle-treated, pair-gained controls. After 12 days of treatment fenfluramine treated animals had sympathetic firing rates which were still slightly but significantly higher than those of the vehicle-treated controls whereas the vehicle-treated, pair-gained animals had a small but significantly reduced firing rate. These data support the hypothesis that fenfluramine can increase peripheral sympathetic activity.

Detection of human papillomavirus DNA in fine-needle aspirations of metastatic squamous-cell carcinoma of the uterine cervix using the polymerase chain reaction.

Abstract: Routinely processed fine-needle aspirations of metastatic squamous-cell carcinoma (SCC) were analyzed for human papillomavirus type 16 (HPV-16) using the polymerase chain reaction (PCR), an in vitro DNA amplification method. HPV-16 DNA was detected in five of seven (71%) metastases from SCC of the uterine cervix. In two cases in which the primary tumor was available for comparison, the HPV-16 DNA content of the primary tumor and of the metastasis was identical. HPV-16 was not found in a metastatic SCC from the lung or in a metastatic nasopharyngeal SCC. These findings demonstrate that HPV-16 DNA sequences can be readily detected in routinely processed fine-needle aspirations using the polymerase chain reaction. The finding of HPV-16 DNA in a metastasis may serve to direct a search for a primary site of origin.