LAC+USC Medical Center

About: LAC+USC Medical Center is a healthcare organization based out in Los Angeles, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 1348 authors who have published 886 publications receiving 21927 citations. The organization is also known as: County/USC & Los Angeles County General.

Coronary artery-left ventricular communications: a report of two cases and review of the literature.

Abstract: Two patients with chest pain had angiographically-demonstrated communications between the three coronary arteries and the left ventricular chamber. Communications between coronary arteries and the left ventricle are unusual and communications between all three coronary arteries and the left ventricle are rare. These anomalies are, however, commonly associated with symptoms of chest pain. The presence of left ventricular hypertrophy and a widened pulse pressure may suggest a greater hemo-dynamic effect of the shunt flow than often suspected angiographically.

Randomized double-blind comparison of three dose levels of intravenous ondansetron in the prevention of cisplatin-induced emesis.

Abstract: The selective 5-hydroxytryptamine3 (5HT3) antagonist ondansetron has been shown to be an effective antiemetic in patients receiving cisplatin chemotherapy. This double-blind study compared the efficacy and safety of three doses of intravenous ondansetron in the prevention of nausea and vomiting associated with high-dose (≥100 mg/m2) cisplatin chemotherapy. A total of 125 patients were randomized (1∶1∶1) to receive 0.015, 0.15, or 0.30 mg/kg every 4 h for a total of 3 doses. All patients were monitored for emetic episodes, adverse events, and laboratory safety parameters for 24 h following cisplatin administration. The 0.15-mg/kg dose was superior to the 0.015-mg/kg dose with respect to the median number of emetic episodes (P=0.033) and complete response (no emetic episodes,P=0.005). No statistically significant difference was found between the 0.15 and the 0.30-mg/kg groups. The most common adverse event was headache. Three 0.15-mg/kg doses of intravenous ondansetron are safe, effective, and adequate for the control of cisplatin-induced emesis.

The experience with definitive irradiation of clinically limited squamous cell cancer of the trachea.

Abstract: Squamous cell cancer of the trachea is an uncommon malignancy infrequently cured by either surgery or irradiation. Failure to control the primary tumor has been the most common cause for death. Our experience in three patients with small squamous cell cancer of the trachea treated by definitive irradiation is encouraging. The primary tumor was controlled in each patient. Histologic confirmation of tumor sterilization was observed in two. One patient remains alive and well at 54 months; one patient developed an epidural metastases at 16 months and subsequently died; and the third patient developed a separate primary lung cancer at 48 months. Two patients developed significant radiation complications.