Leicester General Hospital

About: Leicester General Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Transplantation. The organization has 2481 authors who have published 3034 publications receiving 107437 citations.

An observational study of the prescribing and administration of intravenous drugs in a general hospital

Abstract: The prescribing and administration of intravenous drugs on two surgical and one medical ward were studied to determine the number, type and causes of errors occurring. The errors were classified for potential to harm the patient and for implications for the system of supply, preparation and administration. Of the 154 patients, 46.7 per cent were prescribed intravenous drugs. Of the 178 prescriptions for intravenous drugs, 14 per cent failed to conform to the local policy on prescribing and 11.2 per cent were considered to be clinically inappropriate. Preparation and administration were observed for 41.5 per cent of all scheduled intravenous doses during the 39-day study period. Excluding wrong time errors, the intravenous error rate was 26.9 per cent. Most errors were omissions (12.5 per cent of all observations), of which 45 per cent were due to lack of venous access and 22.5 per cent due to improper use of the drug chart. The latter also caused two errors of extra dosing. Fifty-two per cent of doses were given at the wrong time. Of the 254 errors, 4.7 per cent were classed as of major consequence for the patient, 17.3 per cent classed as moderate and 77.9 per cent as minor. Although the majority of errors observed were of minor consequence for the patient, the intravenous medication error rate could be reduced by using knowledge of the causes observed to change or reinforce the existing system of intravenous drug supply, preparation and administration.

Questionnaires: the use and abuse of social survey methods in medical research

Abstract: We present a working review of survey methods based on market research technology. The structure of questionnaires, their distribution and analysis, are considered, together with techniques for increasing response rates.

Kidney transplantation from non heart-beating donors.

Abstract: The use of non heart-beating donor (NHBD) kidneys to expand transplant programmes offers an answer to the problem of donor shortage. This source of kidneys is utilised by very few renal transplant units despite longstanding and growing evidence of equivalent graft function and survival, compared with cadaveric donor organs. This article reviews the selection criteria, technical approaches and logistical organisation involved in NHBD kidney retrieval and transplantation and outlines the evidence for graft function and survival, and patient outcome. The ethical and legal implications of running a NHBD programme are discussed, and some areas of current and likely future research are covered

The childhood and family background of women with clinical eating disorders: a comparison with women with major depression and women without psychiatric disorder.

Abstract: Background. Childhood antecedents are often put forward as being of possible aetiological significance for both anorexia nervosa and bulimia nervosa. Method. Comparisons were made of groups of women with eating disorders with groups of women with major depression or without current psychiatric disorder, using the Childhood Experience of Care and Abuse interview (CECA). Results. Women with bulimia nervosa (or mixed bulimia and anorexia nervosa) tended to report more troubled childhood experiences than did women from the non-morbid comparison group. In this respect, they resembled those with major depression. In contrast, those with anorexia nervosa resembled the non-morbid women rather than the other psychiatric groups. Conclusions. Adversity in childhood as measured by the CECA may play a part in the causation of bulimia nervosa but not of anorexia nervosa. It remains possible that more specific or subtle family influences may be relevant.

Trends in Mortality of Childhood-onset Insulin-dependent Diabetes Mellitus in Leicestershire: 1940--1991

Abstract: The relative risk of death by calendar date of diagnosis was investigated in a population-based incident cohort of 845 (463 males:382 females) IDDM diagnosed in Leicestershire before the age of 17 years between 1940 and 1989. The mortality status of 844 (99.9 %) patients was determined as of the 31 December 1991, representing 14 346 person-years of risk. Trends in relative risk of death were investigated using Cox proportional hazards modelling for within cohort comparisons and age/sex and calendar time adjusted standardized mortality ratios (SMR) using generalized linear modelling for external comparisons. Median age at diagnosis was 10 years (range 3 months to 16 years); median duration of diabetes 15 years (range 1–51 years). Forty-four patients had died (5.2 %; median age at death 31 years, range 11–51 years). A further four patients died at presentation (within 24 h) from ketoacidosis and are excluded from all analyses. Calendar date of diagnosis was found to be an important predictor of mortality. Adjusting for attained age there was evidence of a decline in relative risk of death with calendar date of diagnosis of 3.4 % (95 % CI, 0.005–6.9 %) per annum, equivalent to a 32 % fall per decade (95 % CI, 5–51 %), or 84 % (95 % CI, 21–97) from 1940 to 1989. The data are consistent with a large fall in mortality between the 1940s and 1950s representing over 50 % of the total reduction in mortality between 1940 and 1991. Neither sex nor age at diagnosis were significant predictors of mortality. Over the study period 1940–89 the SMR (male and female combined) fell from 981 (541–1556) to 238 (60–953) relative to the general population. This population-based study shows that the prognosis for Type 1 (insulin-dependent) diabetes mellitus has improved markedly over the period 1940–1991.