Leicester General Hospital

About: Leicester General Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Transplantation. The organization has 2481 authors who have published 3034 publications receiving 107437 citations.

The use of denial in an ethnically diverse British cancer population: a cross-sectional study

Abstract: A total of 82 Asian and 117 randomly selected white Caucasian patients at the Leicestershire Cancer Centre were assessed using measures of coping and adaption to cancer. On the Mental Adjustment to Cancer (MAC) scale, Asian patients were more fatalistic (P < 0.0001) and had more significant hopeless/helpless scores (P = 0.007). The two ethnic groups answered the three questions thought to assess denial differently. Caucasians were more likely not to dwell on their illness (73 vs 55.5%, P < 0.0001) and agree with the statement 'I have difficulty believing this is happening to me' (73 vs 60.5%, P < 0.0001). However, Asian patients were more likely to agree with the statement 'I don't really believe I have cancer' (48.2 vs 31.3%, P = 0.019). Within both groups there was an association with denial and anxious preoccupation (P < 0.001). On the Hospital Anxiety and Depression (HAD) scale, there was no difference in anxiety scores between either sexes or between the Asian and Caucasian groups. However, Asian patients were more depressed (P = 0.001). Although denial was significantly related to the presence of both depression (P < 0.0001) and anxiety (P = 0.001) in the entire patient population, there were different predictors of denial in each subgroup. On multiple regression analysis depression was linked with denial in Caucasians, whereas Fighting Spirit (minus helplessness/hopelessness) was linked with denial in Asian patients. There are definite differences in coping styles in British cancer patients according to ethnicity. While significant numbers in both groups employ denial in some form, Caucasian patients appear to adapt to the psychological pressures of cancer more successfully than Asian patients at a particular point in time. Further work is required to elucidate longitudinal relationships between denial and adaption to cancer.

Randomized controlled trial comparing the efficacy of a video and information leaflet versus information leaflet alone on patient knowledge about surveillance and cancer risk in ulcerative colitis.

Abstract: Background and Aims Knowledge of colorectal cancer risk in patients with ulcerative colitis is inadequate. The authors aimed to improve knowledge in a sample of patients and determine whether this was best achieved by a simple information leaflet or by watching a video and reading a leaflet. Materials and Methods Patients (n = 124) were recruited into a randomized controlled trial conducted from the gastroenterology outpatient departments of two Leicester hospitals. Participants completed a questionnaire prior to receiving the leaflet or viewing the video, immediately afterward, and 1 month later. Results One hundred fifteen questionnaires were returned (response rate = 93%). Both videos and leaflets increased knowledge with mean percentage improvements in scores of 71% (95% CI = 40.2–100) and 49% (95% CI = 32.1–66), respectively. However, the difference between the two interventions was not statistically significant (Difference = 22%, 95% CI = −56.3–13.2, p = 0.2). After 1 month, knowledge levels decreased in both groups to 55% (95% CI = 33.2–75.8; video plus leaflet) and 36% (95% CI = 23.7–48.6; leaflet alone). Conclusions Leaflets and videos have an important role in reinforcing information provided by clinicians. However, there appears to be no immediate or prolonged advantage of a video over and above that of a simple information leaflet. The cost implications of producing a video, such as extra staff time, need to be weighed against the minor benefit that this medium has to offer.

Lack of correlation between self-reported symptoms of dyspepsia and infection with Helicobacter pylori, in a general population sample.

Abstract: ObjectiveTo investigate any correlation between infection with Helicobacter pylori (H. pylori) and overall symptoms of dyspepsia, in a general population sample.DesignAnalysis of test results and questionnaire replies from a population screening study involving subjects registered at a single genera

Differentiating between audit and research: postal survey of health authorities' views

Abstract: Access to patients and their records for non-clinical purposes has recently come under scrutiny.1 Research ethics committees control access for research purposes, but audit is explicitly excluded from their remit.2 Although there is consensus that locally organised audits do not need ethical approval, the status of larger scale audits designed to influence broader practice remains unclear; some journals do not publish papers based on clinical audit data if they do not have ethical approval.3 Guidelines published by the Royal College of Physicians suggest submission to a research ethics committee if doubt exists about whether a project is audit or research.4 We recently completed a national audit of screening for diabetic retinopathy The aim of the audit was to identify factors associated with screening coverage and to provide baseline data for local audit cycles. The study involved …

Normothermic kidney preservation.

Abstract: Purpose of reviewKidneys from marginal or donation after cardiac death (DCD) donors are particularly susceptible to injury during hypothermic preservation and may benefit from alternative methods of preservation. Normothermic preservation can be adapted to improve the quality of kidneys for transpla