Leicester General Hospital

About: Leicester General Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Transplantation. The organization has 2481 authors who have published 3034 publications receiving 107437 citations.

Changes in diameter of the abdominal aorta with age : An epidemiological study

Abstract: Rupture of abdominal aortic aneurysms is a major cause of death for men who are over 60 years old. This study invited 13,000 men aged 60 to 75 years, within the Birmingham conurbation, to have an ultrasound scan of the abdominal aorta. The scan was performed at the patients' own General Practitioner's surgery; 10,061 men were scanned. Only 3% of this population were found to have large aneurysms. An analysis of the distribution of aortic diameters in this population shows that for diameters less than 40 mm, changes in the diameter with age (previously attributed to the growth of small aneurysms) occurs for up to 25% of the population although the median diameter for each year group, 21 mm, does not increase with age. This analysis suggests that the threshold diameter at which the aorta is categorized as abnormal should be related to age, especially by those undertaking mass screening.

Weight concern should not be a necessary criterion for the eating disorders: a polemic.

Abstract: Problems associated with the inclusion of weight concern as a necessary and defining criterion for the diagnosis of the eating disorders are reviewed. It is proposed that the substitution of the criterion of eating restraint that is overinvested by the subject might have advantages for both clinical classification and for research.

Efficacy and safety of insulin degludec given as part of basal-bolus treatment with mealtime insulin aspart in type 1 diabetes: a 26-week randomized, open-label, treat-to-target non-inferiority trial.

Abstract: Aims The efficacy and safety of insulin degludec (IDeg) was compared with insulin detemir (IDet), both administered once daily (OD) as basal treatment in participants with type 1 diabetes mellitus (T1DM). The primary outcome was non-inferiority of IDeg to IDet in glycated haemoglobin (HbA1c) reduction after 26 weeks. Methods This multinational, 26-week, controlled, open-label, parallel-group trial randomized adults with T1DM to IDeg or IDet as OD basal insulin treatment combined with mealtime bolus insulin aspart (IAsp). Participants with T1DM treated with any basal–bolus insulin regimen for ≥12 months prior to the trial, a mean HbA1c ≤ 10.0% (85.8 mmol/mol) and body mass index (BMI) ≤35.0 kg/m2 at screening participated in the trial (IDeg: N = 302; IDet: N = 153). Results After 26 weeks, HbA1c decreased 0.73% (8.0 mmol/mol) (IDeg) and 0.65% (7.1 mmol/mol) (IDet) [estimated treatment difference (ETD) IDeg–IDet: −0.09% (−0.23; 0.05)95%CI (−10.0 mmol/mol [−2.6; 0.6]95% CI); confirming non-inferiority]. Mean fasting plasma glucose improved in both groups, and was lower with IDeg than IDet [ETD IDeg–IDet: −1.66 mmol/l (−2.37; −0.95)95% CI, p < 0.0001]. The rate of confirmed hypoglycaemia was similar with IDeg and IDet [45.83 vs. 45.69 episodes per patient-year of exposure (PYE); estimated rate ratio (RR) IDeg/IDet: 0.98 (0.80; 1.20)95% CI, p = 0.86]. The rate of nocturnal confirmed hypoglycaemia was lower with IDeg than IDet [4.14 vs. 5.93 episodes per PYE; RR IDeg/IDet: 0.66 (0.49; 0.88)95% CI, p = 0.0049]. Adverse event profiles were similar between groups. Conclusion IDeg administered OD in basal–bolus therapy effectively improved long-term glycaemic control in participants with T1DM with a lower risk of nocturnal confirmed hypoglycaemia than IDet.

Possible Asperger's syndrome in a mentally handicapped transvestite offender

Abstract: A 38-year-old man with a moderate mental handicap and Asperger's syndrome is described. His transvestism and history of offending behaviour is interpreted in the light of this.