Leicester General Hospital

About: Leicester General Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Transplantation. The organization has 2481 authors who have published 3034 publications receiving 107437 citations.

Accuracy of self-reported weight and height among women with eating disorders: a replication and extension study.

Abstract: Objective Self-reported height and weight data are commonly reported within eating disorders research, and often used clinically. The aims of this study are to demonstrate the accuracy of self-reported height and weight among a group of women with eating disorders, and to determine whether that accuracy is associated with clinical diagnosis or levels of eating psychopathology. Method Sixty-four female patients (39 diagnosed with Anorexia Nervosa or atypical Anorexia Nervosa and 25 with Bulimia Nervosa or atypical Bulimia Nervosa) were asked to self-report their height and weight. They then completed the Eating Disorders Examination-Questionnaire (EDE-Q). Finally, they were weighed and their height was measured in a standardised manner. Accuracy scores for height and weight were calculated by subtracting their actual weight and height from their self-reports. Results Both diagnostic groups were relatively accurate in self-reporting their height. However, women with Bulimia Nervosa or atypical Bulimia Nervosa significantly underestimated their weight while women with Anorexia Nervosa or atypical Anorexia Nervosa overestimated it. Weight estimation was associated with higher levels of restraint among the Anorexia Nervosa group only. Discussion These findings highlight the importance of obtaining objective height and weight data both within clinical and research settings. Copyright © 2009 John Wiley & Sons, Ltd and Eating Disorders Association.

Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort.

Abstract: Background The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification. We tested for each lesion the associations between the type of agreement (local and central pathologists scoring absent, local present and central absent, local absent and central present, both scoring present) with the initial clinical assessment, as well as long-term outcomes in those patients who did not receive CS/IS. Results All glomerular lesions (M, E, C and S) assessed by local pathologists were independently associated with the decision to administer CS/IS therapy, while the severity of tubulointerstitial lesions was not. Reproducibility between local and central pathologists was moderate for S (segmental sclerosis) and T (tubular atrophy/interstitial fibrosis), and poor for M (mesangial hypercellularity), E (endocapillary hypercellularity) and C (crescents). Local pathologists found statistically more of each lesion, except for the S lesion, which was more frequent with central review. Disagreements were more likely to occur when the proportion of glomeruli affected was low. The M lesion, assessed by central pathologists, correlated better with the severity of the disease at presentation and discriminated better with outcomes. In contrast, the E lesion, evaluated by local pathologists, correlated better with the clinical presentation and outcomes when compared with central review. Both C and S lesions, when discordant between local and central pathologists, had a clinical phenotype intermediate to double absent lesions (milder disease) and double present (more severe). Conclusion We conclude that differences in the scoring of MEST-C criteria between local pathologists and a central reviewer have a significant impact on the prognostic value of the Oxford Classification. Since the decision to offer immunosuppressive therapy in this cohort was intimately associated with the MEST-C score, this study indicates a need for a more detailed guidance for pathologists in the scoring of IgAN biopsies.

A study of the effect of Picolax on body weight, cardiovascular variables and haemoglobin concentration.

Abstract: This study compared the effect of Picolax when administered for large bowel preparation in combination with preoperative fasting on body weight, haemoglobin concentration, haematocrit, and cardiovascular variables with matched subjects who were fasted before surgery. Picolax resulted in significantly greater weight loss, increases in haemoglobin concentration combined with cardiovascular changes suggesting hypovolaemia in the Picolax group. Intravenous fluid replacement is recommended in patients receiving Picolax.