Leicester General Hospital

About: Leicester General Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Transplantation. The organization has 2481 authors who have published 3034 publications receiving 107437 citations.

A review of problems following insertion of biliary stents illustrated by an unusual complication

Abstract: Introduction The management of obstructive jaundice resulting from both benign and malignant causes relies heavily on minimally invasive techniques and particularly with the insertion of biliary endoprostheses. Migration of these biliary stents is a well-documented problem and can result in a variety of complications including perforation, intra-abdominal sepsis, fistulae formation, obstruction and appendicitis. Methods A literature search was performed using PubMed examining case reports, published abstracts and reviews to date (2009). In addition, we report a left groin abscess as a previously unreported complication following migration of a biliary endoprosthesis. Findings Stent migration can lead to serious complications and produce significant morbidity and mortality. Symptomatic patients especially those with other co-morbid abdominal pathologies such as colonic diverticulae, parastomal hernia or abdominal hernias may be at an increased risk of perforation especially when straight plastic stents are...

Extracellular matrix and the kidney.

Abstract: Introduction Histopathologists have long recognised that excessive accumulation of extracellular matrix in the kidney is a serious sign of irreversible damage. However, we have rarely attempted further analysis of such accumulations, beyond noting the presence of pink staining material in our haematoxylin and eosin sections, and a rough estimation of its severity. This is remiss of us, as fibrosis of the renal interstitium has repeatedly been reported to be the best single morphological correlate of renal function and prognosis. 2 The purpose of this review is to summarise selected recent developments in this field, and to consider how these developments may alter the ways in which histopathologists might assess the extracellular matrix. Although I will concentrate on the kidney, there are obvious parallels with the assessment of non-neoplastic disease in other organs.