Leicester General Hospital

About: Leicester General Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Transplantation. The organization has 2481 authors who have published 3034 publications receiving 107437 citations.

Improved antisaccade performance with risperidone in schizophrenia.

Abstract: Objective: Antisaccade errors are consistently increased in schizophrenia. As they have been demonstrated only in cross sectional studies, it is unclear how they vary longitudinally or with different medications. In a previous cross sectional study, we reported a trend towards a reduction in error rates in a patient group treated with risperidone, compared with clozapine and sulpiride treated groups. Methods: Gap random and antisaccade paradigms were performed on two occasions in the same sample of DSM-IV schizophrenic patients (n=12) in transition between conventional antipsychotic drugs and risperidone. A cross over design was used with six patients switching from risperidone to conventional (group I) and six in the opposite direction (group II). A control sample (n=12) was also tested on two occasions and their performance compared. The effects of practice between first and second testing and of switching between conventional antipsychotic drugs and risperidone and vice versa was also evaluated. Results: A significant reduction in error rate was demonstrated during risperidone treatment (n=12), compared with conventional APD treatment. Switching from conventional to risperidone produced a reduction in errors, and vice versa. Conclusions: Treatment with risperidone was associated with improvement in antisaccade errors.

Associations Between Sedentary Behaviors and Cognitive Function: Cross-Sectional and Prospective Findings From the UK Biobank.

Abstract: We investigated the cross-sectional and prospective associations between different sedentary behaviors and cognitive function in a large sample of adults with data stored in the UK Biobank. Baseline data were available for 502,643 participants (2006-2010, United Kingdom). Cognitive tests included prospective memory (baseline only: n = 171,585), visual-spatial memory (round 1: n = 483,832; round 2: n = 482,762), fluid intelligence (n = 165,492), and short-term numeric memory (n = 50,370). After a mean period of 5.3 years, participants (numbering from 12,091 to 114,373, depending on the test) also provided follow-up cognitive data. Sedentary behaviors (television viewing, driving, and nonoccupational computer-use time) were measured at baseline. At baseline, both television viewing and driving time were inversely associated with cognitive function across all outcomes (e.g., for each additional hour spent watching television, the total number of correct answers in the fluid intelligence test was 0.15 (99% confidence interval: 0.14, 0.16) lower. Computer-use time was positively associated with cognitive function across all outcomes. Both television viewing and driving time at baseline were positively associated with the odds of having cognitive decline at follow-up across most outcomes. Conversely, computer-use time at baseline was inversely associated with the odds of having cognitive decline at follow-up across most outcomes. This study supports health policies designed to reduce television viewing and driving in adults.

Coracoid impingement syndrome: a literature review

Abstract: Coracoid impingement syndrome is a less common cause of shoulder pain. Symptoms are presumed to occur when the subscapularis tendon impinges between the coracoid and lesser tuberosity of the humerus. Coracoid impingement should be included in the differential diagnosis when evaluating a patient with activity-related anterior shoulder pain. It is not thought to be as common as subacromial impingement, and the possibility of the coexistence of the two conditions must be taken into consideration before treatment of either as an isolated process. If nonoperative treatment fails to relieve symptoms, surgical decompression can be offered as an option.