Leicester General Hospital

About: Leicester General Hospital is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Transplantation. The organization has 2481 authors who have published 3034 publications receiving 107437 citations.

Different types of segmental sclerosing glomerular lesions in six experimental models of proteinuria.

Abstract: From 133 to 615 glomeruli were examined in sections of kidneys from each of 60 animals, representing six rodent models of proteinuria. Particular attention was paid to the position of segmental lesions. Lewis rats given sheep anti-rat glomerular basement membrane antibodies had lesions almost exclusively at the glomerulo-tubular junction. Wistar rats on a diet of 24 per cent casein or with subtotal nephrectomy and a diet of 24 per cent soya had lesions mainly at the hilum. Wistar rats given bovine serum albumin had global lesions but virtually no segmental lesions. Wistar rats given puromycin aminonucleoside had lesions at the glomerulo-tubular junction and global mesangial abnormalities shortly after the treatment but later developed segmental lesions at all parts of the glomerulus. Untreated BUF/Mna rats had lesions at the glomerulo-tubular junction early in life but later had lesions at all parts of the glomerulus. Untreated NZB/NZW hybrid mice had various types of glomerulonephritis and also had lesions at the glomerulo-tubular junction. These findings showed that (1) segmental lesions at the glomerulo-tubular junction, or glomerular tip, occur in experimental animals, a fact not previously reported, and these tip changes are a common feature in several different models of proteinuria; (2) hilar segmental lesions are seen in conditions with hyperfiltration of protein; and (3) segmental lesions at various parts of the glomerulus are seen in some models of proteinuria and probably indicate late effects of random toxic damage to the glomerulus. Thus, there are at least three different types of segmental glomerular lesions in experimental animals--tip, hilar, and random--with different morphology and pathogenesis. It is likely that these findings can be extended to human renal diseases with segmental glomerular lesions. This will help to clarify the controversial and unsatisfactory term focal segmental glomerulosclerosis.

Long term prognosis of women with gestational diabetes in a multiethnic population.

Abstract: Aim: To assess the glucose tolerance of South Asian and Caucasian women with previous gestational diabetes mellitus (GDM). Method: A retrospective follow-up study of 189 women diagnosed with GDM between 1995 and 2001. Glucose tolerance was reassessed by oral glucose tolerance test at a mean duration since pregnancy of 4.38 years. Results: South Asian women comprised 65% of the GDM population. Diabetes developed in 36.9% of the population, affecting more South Asian (48.6%) than Caucasian women (25.0%). Women developing diabetes were older at follow-up (mean (SD) 38.8 (5.7) vs 35.9 (5.6) years; p 2 ; p 0 6.5 (1.7) vs 5.2 (1.1) mmol/l; p 120 11.4 (3.3) vs 9.6 (1.8) mmol/l; p Conclusion: GDM represents a significant risk factor for future DM development regardless of ethnicity. Glycated haemoglobin values at GDM diagnosis have value in predicting future diabetes mellitus.

Housebound elderly people: Definition, prevalence and characteristics

Abstract: This study examines various physical, psychiatric, social and environmental factors associated with being housebound in an urban elderly community sample. Using a narrow definition of houseboundness, the overall rate in this sample was 3.5%; in respondents aged 85 years and over the rate was 20.0%. In a logistic regression analysis, physical health status, age, access to a car, floor of entry to household and household tenure emerged as significant independent predictors of houseboundness. Psychiatric disorder was not independently associated with houseboundness in this analysis. Housebound respondents reported higher rates of both formal and informal care; in those aged 65–74 years this extra care was provided by domiciliary health and social services, but in those aged 85 years and over only care by home helps and by family and friends was increased.