Media Research Center

About: Media Research Center is a based out in . It is known for research contribution in the topics: Collaborative learning & Educational technology. The organization has 491 authors who have published 950 publications receiving 28581 citations. The organization is also known as: MRC.

Coping with bad-mouthing in peer-to-peer file sharing networks.

Abstract: In the recent years, the P2P file sharing systems have adopted rating systems in the hope to stop the propagation of bad files. In a rating system, users rate files after downloading and a file with positive feedback is considered a good file. However, a dishonest rater can undermine the rating system by giving positive rating to bad files and negative rating to good files. In this paper, we design two filters based on probabilistic models such that the good files with negative feedback are not completely kept out of the system. The first filter is based on the binomial distribution of the ratings of a file, and the second filter considers the confidence of the downloading peer and the difference of positive and negative ratings of a file to calculate the probability to take a risk to download the file or reject it. Our filters only need the ratings of a file and this makes them suitable for popular torrent sharing websites that rank the files using a binary rating system without any information about raters. In addition, we can implement them entirely on the client side without any modification to the content sharing sites.

Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

Abstract: Condensins are genome organisers that shape chromosomes and promote their accurate transmission. Several studies have also implicated condensins in gene expression, although the mechanisms have remained enigmatic. Here, we report on the role of condensin in gene expression in fission and budding yeasts. In contrast to previous studies, we provide compelling evidence that condensin plays no direct role in the maintenance of the transcriptome, neither during interphase nor during mitosis. We further show that the changes in gene expression in post-mitotic fission yeast cells that result from condensin inactivation are largely a consequence of chromosome missegregation during anaphase, which notably depletes the RNA-exosome from daughter cells. Crucially, preventing karyotype abnormalities in daughter cells restores a normal transcriptome despite condensin inactivation. Thus, chromosome instability, rather than a direct role of condensin in the transcription process, changes gene expression. This knowledge challenges the concept of gene regulation by canonical condensin complexes.

Research priorities for HIV/M. tuberculosis co-infection

Abstract: MS is funded by the EU; AM is funded by the EU and the Bill and Melinda Gates foundation. The EUCO-Net project leading to these results has received funding from the European Community's Seventh Framework Programme.

Towards an it solution to support reflective learning at the workplace

Abstract: The successful management of learning and knowledge has become a critical success factor for organisations in today’s knowledge-intensive business world. Reflection on work practice has been identified as one of the central mechanisms of learning at work. It leads to a better understanding of work-related experiences and can guide future behavior. However, it has not been discussed so far how reflection may help organisations to react to changing conditions and business environments and how this kind of organisational learning may be supported by an appropriate Information System. Based on a well-accepted model in reflective learning theory and key findings from a study, the paper contributes to closing this gap by proposing a solution, which can be used even if no other Information Technology support is available within the corporate environment. Accordingly, the development and the prototypical implementation of two applications supporting reflective learning at the workplace are described in detail.