Institution
Monroe Carell Jr. Children's Hospital at Vanderbilt
Healthcare•
About: Monroe Carell Jr. Children's Hospital at Vanderbilt is a based out in . It is known for research contribution in the topics: Population & Medicine. The organization has 1046 authors who have published 1262 publications receiving 28063 citations. The organization is also known as: Vanderbilt Children's Hospital.
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TL;DR: Favorable outcomes can be achieved with RIC approaches in pediatric patients in remission who are ineligible for myeloablative transplantation.
80 citations
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TL;DR: Ureteroscopy is a safe method for the treatment of intrarenal calculi in the prepubertal population but parents should be informed that additional procedures will likely be required, especially in younger patients and those with stones larger than 6 mm.
79 citations
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TL;DR: It is demonstrated that milrinone use on admission to the cardiac intensive care unit remained independently associated with an increase in the odds of postoperative tachyarrhythmia resulting in an intervention, and was an independent risk factor for clinically significant tachyARRhythmias in the early postoperative period after congenital heart surgery.
Abstract: Milrinone reduces the risk of low cardiac output syndrome for some pediatric patients after congenital heart surgery. Data from adults undergoing cardiac surgery suggest an association between milrinone and an increased risk of postoperative arrhythmias. We tested the hypothesis that milrinone is an independent risk factor for tachyarrhythmias after congenital heart surgery. Subjects undergoing congenital heart surgery at our institution were consecutively enrolled for 38 months, through September 2010. The data were prospectively collected, including a review of full-disclosure telemetry and the medical records. Within 38 months, 603 enrolled subjects underwent 724 operative procedures. The median age was 5.5 months (range 0.0 to 426), the median weight was 6.0 kg (range 0.7 to 108), and the cohort was 45% female. The overall arrhythmia incidence was 50%, most commonly monomorphic ventricular tachycardia (n = 85, 12%), junctional ectopic tachycardia (n = 69, 10%), accelerated junctional rhythm (n = 58, 8%), and atrial tachyarrhythmias (including atrial fibrillation, atrial flutter, and ectopic or chaotic atrial tachycardia, n = 58, 8%). Multivariate logistic regression analysis demonstrated that independent of age 3, and the use of epinephrine or dopamine, milrinone use on admission to the cardiac intensive care unit remained independently associated with an increase in the odds of postoperative tachyarrhythmia resulting in an intervention (odds ratio 2.8, 95% confidence interval 1.3 to 6.0, p = 0.007). In conclusion, milrinone use is an independent risk factor for clinically significant tachyarrhythmias in the early postoperative period after congenital heart surgery.
77 citations
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TL;DR: It is suggested that parental activity levels are a powerful explanation of preschool-aged child activity levels, except for vigorous activity, which children do on their own without parental participation.
Abstract: OBJECTIVE: The goal of this study was to examine activity pattern associations between Hispanic parents and their preschool-aged children. METHODS: We examined baseline data collected as part of a randomized controlled trial. Self-defined Hispanic parents with children aged 3 to 5 years were randomly assigned to either a weekly healthy lifestyle group (intervention) or a monthly school-readiness group (control) for 3 months. There were no weight eligibility criteria. All participants were instructed to wear an accelerometer for up to 7 consecutive days to measure physical activity. RESULTS: Of the 106 dyads enrolled in the study, 80 children and 85 parents provided useable actigraphy data. Mean percentage of time spent in sedentary behaviors was 82.0% (SD: 10.4) for parents and 69.8% (SD: 18.5) for preschool-aged children. Percentage of awake time per day spent in sedentary behavior was strongly correlated for parents and children (r = 0.597; P CONCLUSIONS: These results suggest that parental activity levels are a powerful explanation of preschool-aged child activity levels, except for vigorous activity, which children do on their own without parental participation. Hispanic parents play a critical role in setting physical activity patterns in their children.
76 citations
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University of British Columbia1, Monroe Carell Jr. Children's Hospital at Vanderbilt2, University of Rochester3, University of Utah4, University of Wisconsin-Madison5, University of Washington6, Boston Children's Hospital7, University of Toronto8, Royal Children's Hospital9, University of Michigan10, University of Colorado Boulder11, Leipzig University12, Alfred I. duPont Hospital for Children13, University of California, Irvine14, Charles University in Prague15, Children's Hospital Los Angeles16, University of Alberta17, Technische Universität München18, University of Alabama at Birmingham19, University of Louisville20
TL;DR: This large, multicentre study identifies contemporary challenges related to the diagnosis and prognostication of CPVT patients andStructural modelling of RyR2 can improve the understanding of severe CPVT phenotypes.
Abstract: Aims: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an ion channelopathy characterized by ventricular arrhythmia during exertion or stress. Mutations in RYR2-coded Ryanodine Receptor-2 (RyR2) and CASQ2-coded Calsequestrin-2 (CASQ2) genes underlie CPVT1 and CPVT2, respectively. However, prognostic markers are scarce. We sought to better characterize the phenotypic and genotypic spectrum of CPVT, and utilize molecular modelling to help account for clinical phenotypes. Methods and results: This is a Pediatric and Congenital Electrophysiology Society multicentre, retrospective cohort study of CPVT patients diagnosed at <19 years of age and their first-degree relatives. Genetic testing was undertaken in 194 of 236 subjects (82%) during 3.5 (1.4-5.3) years of follow-up. The majority (60%) had RyR2-associated CPVT1. Variant locations were predicted based on a 3D structural model of RyR2. Specific residues appear to have key structural importance, supported by an association between cardiac arrest and mutations in the intersubunit interface of the N-terminus, and the S4-S5 linker and helices S5 and S6 of the RyR2 C-terminus. In approximately one quarter of symptomatic patients, cardiac events were precipitated by only normal wakeful activities. Conclusion: This large, multicentre study identifies contemporary challenges related to the diagnosis and prognostication of CPVT patients. Structural modelling of RyR2 can improve our understanding severe CPVT phenotypes. Wakeful rest, rather than exertion, often precipitated life-threatening cardiac events.
76 citations
Authors
Showing all 1056 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dan M. Roden | 132 | 859 | 67578 |
Kathryn M. Edwards | 102 | 628 | 39467 |
Agnes B. Fogo | 98 | 578 | 38840 |
James E. Crowe | 83 | 430 | 22045 |
Luc Van Kaer | 79 | 261 | 26242 |
John A. Phillips | 69 | 270 | 16980 |
Louis J. Muglia | 68 | 254 | 15777 |
Douglas B. Johnson | 65 | 331 | 18439 |
Keith T. Wilson | 63 | 238 | 13002 |
Michael R. DeBaun | 62 | 369 | 14812 |
Simon W. Hayward | 61 | 191 | 13131 |
Wendy L. Stone | 61 | 150 | 17231 |
Arnold W. Strauss | 60 | 209 | 10792 |
Dominique Delbeke | 59 | 170 | 14652 |
Thomas B. Newman | 58 | 239 | 11638 |