Institution
Newcastle University
Education•Newcastle upon Tyne, United Kingdom•
About: Newcastle University is a education organization based out in Newcastle upon Tyne, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 31772 authors who have published 71187 publications receiving 2539147 citations. The organization is also known as: University of Newcastle upon Tyne.
Papers published on a yearly basis
Papers
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TL;DR: The paper concludes by showing how the obtained error bounds can be used for intelligent model order selection that takes into account both measurement noise and under-model- ing.
Abstract: Previous results on estimating errors or error bounds on identified transfer functions have relied on prior assumptions about the noise and the unmodeled dynamics. This prior information took the form of parameterized bounding functions or parameterized probability density functions, in the time or frequency domain with known parameters. It is shown that the parameters that quantify this prior information can themselves be estimated from the data using a maximum likelihood technique. This significantly reduces the prior information required to estimate transfer function error bounds. The authors illustrate the usefulness of the method with a number of simulation examples. How the obtained error bounds can be used for intelligent model-order selection that takes into account both measurement noise and under-modeling is shown. Another simulation study compares the method to Akaike's well-known FPE and AIC criteria. >
370 citations
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TL;DR: The aggregate data show health care to be, if anything, a necessity rather than a luxury good, and this paper argues that these implications rely upon the application of microeconomic analysis to macroeconomic data, and that this is not appropriate.
370 citations
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University of Bristol1, Medical Research Council2, Newcastle University3, University of London4, University of Glasgow5, University of Southampton6, Seconda Università degli Studi di Napoli7, Ghent University8, University of Southern Denmark9, University of British Columbia10, Tulane University11, University of Edinburgh12, University of Michigan13, University of Washington14, University of Utah15, Kyungpook National University16, Yeshiva University17, Rutgers University18, Kyushu University19, King's College London20, Katholieke Universiteit Leuven21, Lund University22, Umeå University23, University of Calgary24, The Chinese University of Hong Kong25, University of Groningen26, University of Texas Southwestern Medical Center27, National Institutes of Health28
TL;DR: Telomere length is longer in females than males, although this difference was not universally found in studies that did not use Southern blot methods, and further research on explanations for the methodological differences is required.
370 citations
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TL;DR: The contribution of genes within the major histocompatability complex to rheumatoid arthritis has been calculated using data from hospital‐ and population‐based studies of monozygotic twin concordance rates and sibling recurrence risks, along with material from published haplotype‐sharing studies.
Abstract: The contribution of genes within the major histocompatibility complex to rheumatoid arthritis has been calculated (Rotter & Landaw 1984). Separate data from hospital- and population-based studies of monozygotic twin concordance rates and sibling recurrence risks have been used, along with material from published haplotype-sharing studies. Using either source of information gives the same result, a contribution of 37%.
369 citations
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TL;DR: Through rational drug development, STI571, a bcr-abl tyrosine kinase inhibitor, has emerged as targeted therapy that offers new hope for expanded treatment options for patients with CML.
Abstract: The treatment options for chronic myelogenous leukemia (CML) continue to evolve rapidly. Imatinib mesylate (Gleevec, Glivec, formerly STI571) has continued to show remarkable clinical benefits and the updated results with this agent are reviewed. As relapses using single agent imatinib have occurred, particularly in advanced phase patients, the issue of whether combinations of other antileukemic agents with imatinib may yield improved results is addressed. In addition, data on new agents that have potential in the treatment of CML are reviewed. These agents are presented in the context of their molecular mechanism of action. The most recent data for stem cell transplantation, along with advances in nonmyeloablative transplants, are also reviewed. In Section I, Drs. Stephen O'Brien and Brian Druker update the current status of clinical trials with imatinib and review ongoing investigations into mechanisms of resistance and combinations of imatinib with other agents. They also present their views on integration of imatinib with other therapies. In Section II, Dr. Jorge Cortes describes the most recent data on novel therapies for CML, including farnesyl transferase inhibitors, arsenic trioxide, decitabine, and troxatyl, among others. These agents are discussed in the context of their molecular mechanism of action and rationale for use. In Section III, Dr. Jerald Radich updates the results of stem cell transplants for CML, including emerging data on nonmyeloablative transplants. He also presents data on using microarrays to stratify patients into molecularly defined risk groups.
369 citations
Authors
Showing all 32219 results
Name | H-index | Papers | Citations |
---|---|---|---|
Martin White | 196 | 2038 | 232387 |
Barry Halliwell | 173 | 662 | 159518 |
Adrian L. Harris | 170 | 1084 | 120365 |
Jorge E. Cortes | 163 | 2784 | 124154 |
Frank J. Gonzalez | 160 | 1144 | 96971 |
David W. Bates | 159 | 1239 | 116698 |
Nicholas J. Talley | 158 | 1571 | 90197 |
Hans Lassmann | 155 | 724 | 79933 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Edmund T. Rolls | 153 | 612 | 77928 |
David J. Brooks | 152 | 1056 | 94335 |
Andrew J. Lees | 140 | 877 | 91605 |
Daniel Thomas | 134 | 846 | 84224 |
Peter Hall | 132 | 1640 | 85019 |
Paul Brennan | 132 | 1221 | 72748 |