Institution
Newcastle University
Education•Newcastle upon Tyne, United Kingdom•
About: Newcastle University is a education organization based out in Newcastle upon Tyne, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 31772 authors who have published 71187 publications receiving 2539147 citations. The organization is also known as: University of Newcastle upon Tyne.
Papers published on a yearly basis
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TL;DR: It is shown that a porous organic cage molecule has unprecedented performance in the solid state for the separation of rare gases, such as krypton and xenon, and selective binding of chiral organic molecules such as 1-phenylethanol, suggesting applications in enantioselective separation.
Abstract: The separation of molecules with similar size and shape is an important technological challenge. For example, rare gases can pose either an economic opportunity or an environmental hazard and there is a need to separate these spherical molecules selectively at low concentrations in air. Likewise, chiral molecules are important building blocks for pharmaceuticals, but chiral enantiomers, by definition, have identical size and shape, and their separation can be challenging. Here we show that a porous organic cage molecule has unprecedented performance in the solid state for the separation of rare gases, such as krypton and xenon. The selectivity arises from a precise size match between the rare gas and the organic cage cavity, as predicted by molecular simulations. Breakthrough experiments demonstrate real practical potential for the separation of krypton, xenon and radon from air at concentrations of only a few parts per million. We also demonstrate selective binding of chiral organic molecules such as 1-phenylethanol, suggesting applications in enantioselective separation.
474 citations
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TL;DR: In this paper, the authors propose a method of associating explicit values with anticipated improvements in safety and costs with deteriorations in order that these effects can be weighed in relation to the other desirable and undesirable effects.
Abstract: MISHAN (1971) Public sector allocative and legislative decisions typically involve the assessment of a variety of prospective consequences. In some cases, notably in transport, energy and medical care, these consequences may include significant beneficial or harmful effects on individual safety. If such decisions are to be taken in a systematic and consistent manner and if, in particular, scarce resources are to be allocated efficiently and to greatest advantage, then it would seem to be necessary to have a method of associating explicit values with anticipated improvements in safety - and costs with deteriorations - in order that these effects can be weighed in relation to the other desirable and undesirable
472 citations
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Johns Hopkins University School of Medicine1, University of Oklahoma2, Brigham and Women's Hospital3, University of Kansas4, Newcastle University5, Children's National Medical Center6, University of Utah Hospital7, Washington University in St. Louis8, University of Rochester Medical Center9, University of Texas Southwestern Medical Center10, Ohio State University11
TL;DR: A safety trial of a neutralizing antibody to myostatin, MYO‐029, in adult muscular dystrophies (Becker muscular dystrophy, facioscapulohumeral dystrophia, and limb‐girdle muscular dy Strophy) is conducted.
Abstract: Objective: Myostatin is an endogenous negative regulator of muscle growth and a novel target for muscle diseases. We conducted a safety trial of a neutralizing antibody to myostatin, MYO-029, in adult muscular dystrophies (Becker muscular dystrophy, facioscapulohumeral dystrophy, and limb-girdle muscular dystrophy). Methods: This double-blind, placebo-controlled, multinational, randomized study included 116 subjects divided into sequential dose-escalation cohorts, each receiving MYO-029 or placebo (Cohort 1 at 1mg/kg; Cohort 2 at 3mg/kg; Cohort 3 at 10mg/kg; Cohort 4 at 30mg/kg). Safety and adverse events were assessed by reported signs and symptoms, as well as by physical examinations, laboratory results, echocardiograms, electrocardiograms, and in subjects with facioscapulohumeral dystrophy, funduscopic and audiometry examinations. Biological activity of MYO-029 was assessed through manual muscle testing, quantitative muscle testing, timed function tests, subject-reported outcomes, magnetic resonance imaging studies, dual-energy radiographic absorptiometry studies, and muscle biopsy. Results: MYO-029 had good safety and tolerability with the exception of cutaneous hypersensitivity at the 10 and 30mg/kg doses. There were no improvements noted in exploratory end points of muscle strength or function, but the study was not powered to look for efficacy. Importantly, bioactivity of MYO-029 was supported by a trend in a limited number of subjects toward increased muscle size using dual-energy radiographic absorptiometry and muscle histology. Interpretation: This trial supports the hypothesis that systemic administration of myostatin inhibitors provides an adequate safety margin for clinical studies. Further evaluation of more potent myostatin inhibitors for stimulating muscle growth in muscular dystrophy should be considered. Ann Neurol 2008;63:561–571
472 citations
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TL;DR: The TVT procedure appears to be as effective as colposuspension for the treatment of urodynamic stress incontinence at 2 years, and when data were analyzed on an intention-to-treat basis, this study was undertaken to compare tension-free vaginal tape with colpos Suspension as the primary treatment for stressincontinence.
472 citations
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University of Oldenburg1, VU University Medical Center2, Vrije Universiteit Brussel3, Newcastle University4, Sapienza University of Rome5, University of Parma6, University of Dundee7, University College Dublin8, Ludwig Maximilian University of Munich9, University of Birmingham10, Uppsala University Hospital11, University of Nottingham12, Manchester Metropolitan University13, Mater Misericordiae University Hospital14, University of Erlangen-Nuremberg15
TL;DR: This study shows proof-of-principle that specific nutritional supplementation alone might benefit geriatric patients, especially relevant for those who are unable to exercise.
472 citations
Authors
Showing all 32219 results
Name | H-index | Papers | Citations |
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Martin White | 196 | 2038 | 232387 |
Barry Halliwell | 173 | 662 | 159518 |
Adrian L. Harris | 170 | 1084 | 120365 |
Jorge E. Cortes | 163 | 2784 | 124154 |
Frank J. Gonzalez | 160 | 1144 | 96971 |
David W. Bates | 159 | 1239 | 116698 |
Nicholas J. Talley | 158 | 1571 | 90197 |
Hans Lassmann | 155 | 724 | 79933 |
Stephen J. O'Brien | 153 | 1062 | 93025 |
Edmund T. Rolls | 153 | 612 | 77928 |
David J. Brooks | 152 | 1056 | 94335 |
Andrew J. Lees | 140 | 877 | 91605 |
Daniel Thomas | 134 | 846 | 84224 |
Peter Hall | 132 | 1640 | 85019 |
Paul Brennan | 132 | 1221 | 72748 |