Renji Hospital

About: Renji Hospital is a healthcare organization based out in Shanghai, China. It is known for research contribution in the topics: Medicine & Biology. The organization has 1112 authors who have published 714 publications receiving 15442 citations. The organization is also known as: Rénjì Yīyuàn.

Adaptation Planning

Abstract: AbstractClimate change poses many challenges to sustainable development globally, especially in developing countries (Adger et al. Progress in Development Studies 3(3):179–195, 2003). Adaptation addresses more “realistic and urgent issues” compared with mitigation.

The impact of indirect notification of cancer diagnosis on postoperative esophageal cancer patients in stage T3: A propensity score matching analysis

Abstract: Abstract Background: Chinese doctors are required to inform cancer diagnosis to patients’ direct relatives rather than patients themselves. Patients may be hidden disease from their family members, and it may cause some serious results. Therefore, we carried out a retrospective study to evaluate whether indirect notification of cancer diagnosis can impact the prognosis of postoperative esophageal cancer patients in stage T3.Methods: We selected postoperative T3 esophageal cancer patients hospitalized from June 2015 to December 2016 as research subjects, and divided them into a direct-notification group and an indirect-notification group. Several variables are allowed for evaluating 36-month progress-free survival of the two groups. Propensity score matching analysis were used to adjust selection bias.Results: There were 72 patients enrolled in the study. Sex and indirect notification of cancer diagnosis were significantly predicted poor survival while stage, pathological differentiation, education background and age were not after propensity score matching analysis (P=0.02, 0.02, 0.30, 0.18, 0.07, 0.05, respectively). Cox multivariate regression analysis shows male and indirect notification of cancer diagnosis independentlly predict poor survival of progress-free survival of esophageal cancer at postoperative T3 stage (harzard ratio = 0.264, 95% confidence interval: 0.099-0.703, P=0.01; harzard ratio =2.823, 95% confidence interval: 1.360-5.861, P=0.01, respectively). Conclusions: Indirect notification of cancer diagnosis is an important negative predictors of postoperative esophageal cancer patients' progress-free survival.

Programming Super DNA‐Enzyme Molecules for On‐Demand Enzyme Activity Modulation**

Abstract: Dynamic interactions of enzymes, including programmable configuration and cycling of enzymes, play important roles in the regulation of cellular metabolism. Here, we constructed a super DNA-enzymes molecule (SDEM) that comprises at least two cascade enzymes and multiple linked DNA strands to control and detect metabolism. We found that the programmable SDEM, which comprises glucose oxidase (GOx) and horseradish peroxidase (HRP), has a 20-fold lower detection limit and a 1.6-fold higher reaction rate than free enzymes. An SDEM can be assembled and disassembled using a hairpin structure and a displacement DNA strand to complete multiple cycles. An entropically driven catalytic assembly (catassembly) enables different SDEMs to switch from an SDEM with GOx and HRP cascades to an SDEM with sarcosine oxidase (SOX) and HRP cascades in over six orders of magnitude less time than without the catassembly to detect different metabolisms (GO and sarcosine) on demand.

Achievements of Human Development Goals with Low Emissions

Abstract: AbstractGreenhouse gas emissions come from human economic activities and serve the ultimate target of human race development. Therefore, the reduction of GHG emissions should not compromise human race development. Human race development involves some essential emissions to meet the basic needs of human race development. Meanwhile, some other emissions are unnecessary, luxurious, or wasteful and conflict with the target of human race development.