Institution
Renji Hospital
Healthcare•Shanghai, China•
About: Renji Hospital is a healthcare organization based out in Shanghai, China. It is known for research contribution in the topics: Medicine & Biology. The organization has 1112 authors who have published 714 publications receiving 15442 citations. The organization is also known as: Rénjì Yīyuàn.
Topics: Medicine, Biology, Internal medicine, Chemistry, Cancer
Papers published on a yearly basis
Papers
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TL;DR: Anemia aggravates the hyperdynamic circulation of portal hypertension, and hemoglobin concentration is an important variable for evaluating the degree of hemodynamic disturbance in PHT patients.
7 citations
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TL;DR: IPC has protective effect on the liver function and prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P<0.05) and maintained high level of SOD in the organs.
Abstract: Objective: To study the protective effect of ischemicpreconditioning (IPC) on the hepatic ischemia-reperfusion injury.Methods: The model of rat liver subjected to ischemia/reperfusion (I/R) injury was made. All 24 mice were divided randomly into 3 groups and anesthetized by 2% sodium pentobarbital (30-40 mg/kg). The enzyme activity of AST, ALT, LDH, SOD and the content of LPO were assayed respectively. Specimens were observed under transmission electron microscope.Results: IPC prevented the increase of ALT, AST and LDH in the blood and that of LPO in the tissues (P<0.05), and maintained high level of SOD in the tissues (P<0.05).Conclusions: IPC has protective effect on the liver function.
Key words:
Ischemic preconditioning; Liver; Wounds and injuries; Ischemia-reperfusion
7 citations
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TL;DR: It is suggested that the determination of the surgical margin should be based on a combination of histopathology and molecular biological findings, because ‘normal’ tissue may nevertheless contain the gene mutation, giving rise to the danger of further cancer development.
7 citations
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TL;DR: In this article , the authors summarize the recent developments in the field of targeted antibacterial therapy based on nanomaterials, which will promote more innovative thinking focusing on the treatment of multidrug-resistant bacteria.
Abstract: Bacterial infection has become one of the leading causes of death worldwide, particularly in low-income countries. Despite the fact that antibiotics have provided successful management in bacterial infections, the long-term overconsumption and abuse of antibiotics has contributed to the emergence of multidrug resistant bacteria. To address this challenge, nanomaterials with intrinsic antibacterial properties or that serve as drug carriers have been substantially developed as an alternative to fight against bacterial infection. Systematically and deeply understanding the antibacterial mechanisms of nanomaterials is extremely important for designing new therapeutics. Recently, nanomaterials-mediated targeted bacteria depletion in either a passive or active manner is one of the most promising approaches for antibacterial treatment by increasing local concentration around bacterial cells to enhance inhibitory activity and reduce side effects. Passive targeting approach is widely explored by searching nanomaterial-based alternatives to antibiotics, while active targeting strategy relies on biomimetic or biomolecular surface feature that can selectively recognize targeted bacteria. In this review article, we summarize the recent developments in the field of targeted antibacterial therapy based on nanomaterials, which will promote more innovative thinking focusing on the treatment of multidrug-resistant bacteria.
7 citations
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TL;DR: The overall risk of suicide attempts was 2.23 times higher in the TBI group compared with the non-TBI group after adjustment for covariates, and the risk attempted suicide increased with the severity of TBI.
Abstract: Background Traumatic brain injury (TBI) is a major cause of death and disability worldwide, and its treatment is potentially a heavy economic burden. Suicide is another global public health problem and the second leading cause of death in young adults. Patients with TBI are known to have higher than normal rates of non-fatal deliberate self-harm, suicide and all-cause mortality. The aim of this study was to explore the association between TBI and suicide risk in a Chinese cohort. Method This study analysed data contained in the Taiwan National Health Insurance Research Database for 17 504 subjects with TBI and for 70 016 subjects without TBI matched for age and gender at a ratio of 1 to 4. Cox proportional hazard regression analysis was used to estimate subsequent suicide attempts in the TBI group. Probability of attempted suicide was determined by Kaplan-Meier method. Results The overall risk of suicide attempts was 2.23 times higher in the TBI group compared with the non-TBI group (0.98 vs 0.29 per 1000 person-years, respectively) after adjustment for covariates. Regardless of gender, age or comorbidity, the TBI group tended to have more suicide attempts, and the risk attempted suicide increased with the severity of TBI. Depression and alcohol attributed disease also increased the risk of attempted suicide in the TBI group. Conclusion Suicide is preventable if risk factors are recognised. Hence, TBI patients require special attention to minimise their risk of attempted suicide.
7 citations
Authors
Showing all 1170 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jaap Stoker | 66 | 404 | 15532 |
Nan Shen | 56 | 238 | 13592 |
Carola G. Vinuesa | 54 | 128 | 17433 |
Jing-Yuan Fang | 54 | 289 | 10826 |
Honglan Li | 53 | 199 | 8285 |
Matthew C. Cook | 43 | 119 | 9708 |
Guido N. J. Tytgat | 40 | 102 | 6175 |
Jianrong Xu | 37 | 226 | 4915 |
Eric J.H. Meuleman | 37 | 126 | 6184 |
Xiong Ma | 35 | 127 | 3587 |
Gang Huang | 34 | 116 | 3122 |
Jinke Cheng | 33 | 97 | 4120 |
Jie Xu | 32 | 83 | 3150 |
Steven R. Lindheim | 30 | 186 | 3594 |
Qiang Wu | 29 | 75 | 4203 |