Institution
Royal London Hospital
Healthcare•London, United Kingdom•
About: Royal London Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Medicine. The organization has 4854 authors who have published 5081 publications receiving 168207 citations. The organization is also known as: London Infirmary & London Hospital.
Topics: Population, Medicine, Poison control, Intensive care, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: The relationship between risk of cutaneous malignant melanoma and total body and site‐specific naevus counts and other host factors was investigated in a Caucasian population aged 15–84 years in New South Wales, Australia.
Abstract: The relationship between risk of cutaneous malignant melanoma and total body and site-specific naevus counts and other host factors was investigated in a Caucasian population aged 15-84 years in New South Wales, Australia. The study sample comprised 244 cases with melanoma diagnosed in 1989-1993, and 276 controls. The strongest relationship was with total body naevus count. Risk of melanoma was raised 12 times in those with more than 100 naevi compared with those with less than 10. There were also strong risks, with odds ratios of 5 or more, associated with having multiple atypical naevi, multiple large naevi, high naevus counts in sun-exposed or sun-protected areas and being unable to tan on repeated sun exposure. The effect of inability to tan was stronger at younger than older ages. Lesser risks, with odds ratios of 2-3, were associated with being prone to burn on sun exposure, having many freckles as a child and having red hair. The site distribution of naevi in males compared with females resembled the distribution of melanoma by sex. Risk of melanoma of the back was significantly more closely related to back naevus count than naevus count for the remainder of the body. For other anatomical sites, naevus count was non-significantly more closely related to naevus counts at that site than counts over the remainder of the body. Naevus count declined with age in both cases and controls. In those aged under 40, having 100 or more naevi was associated with an aetiological fraction (AF) of 41%. In those aged 60 and over, however, the AF associated with this number of naevi was only 5%.
113 citations
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California Pacific Medical Center1, University of Miami2, Novartis3, University of Paris4, Columbia University5, University of Milan6, University of Western Ontario7, Royal London Hospital8, University of Toronto9, University of British Columbia10, McGill University11, University of Alberta12, Hannover Medical School13, Humboldt University of Berlin14, University of Amsterdam15, University of Lausanne16, Beaumont Hospital17, King's College London18, State University of New York Upstate Medical University19, University of California, Los Angeles20, Drexel University21, University of Colorado Denver22, University of Utah23, Johns Hopkins University24, University of Wisconsin-Madison25, Cleveland Clinic26, Houston Methodist Hospital27, Indiana University28, Ohio State University29, University of Texas Health Science Center at San Antonio30
TL;DR: The trial revealed no evidence of a beneficial effect of TCH346 on disease progression in patients with ALS and there were no significant differences between placebo and active treatment groups in the mean rate of decline of the ALSFRS-R or in the secondary outcome measures.
Abstract: Background: TCH346 exerts antiapoptotic effects by binding to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and blocking the apoptotic pathway in which GAPDH is involved. Apoptosis is considered to be a key pathogenic mechanism in neurodegenerative diseases including ALS. Methods: Patients were randomly assigned in a double-blind fashion to receive either placebo or one of four doses of TCH346 (1.0, 2.5, 7.5, or 15 mg/day) administered orally once daily for at least 24 weeks. The primary outcome measure was the rate of change in the revised ALS functional rating scale (ALSFRS-R). The trial design included a 16-week lead-in phase to determine each patient9s rate of disease progression. The between treatment comparison was adjusted for the individual pretreatment rates of progression. The study was powered to detect a 25% reduction in the rate of decline of the ALSFRS-R as compared with placebo. Secondary outcome measures included survival, pulmonary function, and manual muscle testing (MMT). Results: Five hundred ninety-one patients were enrolled at 42 sites in Europe and North America. There were no differences in baseline variables. There were no significant differences between placebo and active treatment groups in the mean rate of decline of the ALSFRS-R or in the secondary outcome measures (survival, pulmonary function, and MMT). Conclusion: The trial revealed no evidence of a beneficial effect of TCH346 on disease progression in patients with ALS.
112 citations
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TL;DR: This study demonstrates that transgastric gastroesophageal reflux surgery, by using stitching under EUS control, can significantly increase lower esophageaal sphincter pressure in pigs.
112 citations
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TL;DR: This paper describes a simple approach to emergency thoracotomy that can be used by a doctor in the prehospital environment and in the resuscitation room.
Abstract: This paper describes a simple approach to emergency thoracotomy that can be used by a doctor in the prehospital environment and in the resuscitation room.
112 citations
Authors
Showing all 4863 results
Name | H-index | Papers | Citations |
---|---|---|---|
Mark I. McCarthy | 200 | 1028 | 187898 |
Timothy G. Dinan | 116 | 689 | 60561 |
Nicola Maffulli | 115 | 1570 | 59548 |
Jonathan J Deeks | 109 | 381 | 131283 |
Ashley B. Grossman | 107 | 873 | 45941 |
Jadwiga A. Wedzicha | 104 | 505 | 49160 |
Khalid S. Khan | 92 | 684 | 33700 |
Irene M. Leigh | 91 | 366 | 29347 |
Gavin Giovannoni | 89 | 852 | 38443 |
Christoph Thiemermann | 89 | 474 | 28732 |
Ian Jacobs | 86 | 446 | 28485 |
James W. Ironside | 86 | 590 | 33745 |
Graham Roberts | 83 | 542 | 24822 |
Ezio Bonifacio | 82 | 357 | 22157 |
Peter Hoskin | 82 | 585 | 29453 |