Sharda University

About: Sharda University is a education organization based out in Greater Noida, Uttar Pradesh, India. It is known for research contribution in the topics: Computer science & Medicine. The organization has 1276 authors who have published 2012 publications receiving 16188 citations.

Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System: A Review on Neurological Impairments and Manifestations.

Abstract: The coronavirus disease 2019 (COVID-19) pandemic is an issue of global significance that has taken the lives of many across the world Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for its pathogenesis The pulmonary manifestations of COVID-19 have been well described in the literature Initially, it was thought to be limited to the respiratory system; however, we now recognize that COVID-19 also affects several other organs, including the nervous system Two similar human coronaviruses (CoV) that cause severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) are also known to cause disease in the nervous system The neurological manifestations of SARS-CoV-2 infection are growing rapidly, as evidenced by several reports There are several mechanisms responsible for such manifestations in the nervous system For instance, post-infectious immune-mediated processes, direct virus infection of the central nervous system (CNS), and virus-induced hyperinflammatory and hypercoagulable states are commonly involved Guillain-Barre syndrome (GBS) and its variants, dysfunction of taste and smell, and muscle injury are numerous examples of COVID-19 PNS (peripheral nervous system) disease Likewise, hemorrhagic and ischemic stroke, encephalitis, meningitis, encephalopathy acute disseminated encephalomyelitis, endothelialitis, and venous sinus thrombosis are some instances of COVID-19 CNS disease Due to multifactorial and complicated pathogenic mechanisms, COVID-19 poses a large-scale threat to the whole nervous system A complete understanding of SARS-CoV-2 neurological impairments is still lacking, but our knowledge base is rapidly expanding Therefore, we anticipate that this comprehensive review will provide valuable insights and facilitate the work of neuroscientists in unfolding different neurological dimensions of COVID-19 and other CoV associated abnormalities

Impact of Two Intense Dust Storms on Aerosol Characteristics and Radiative Forcing over Patiala, Northwestern India

Abstract: Impact of dust storms on the aerosol characteristics and radiative forcing over Patiala, northwestern India has been studied during April-June of 2010 using satellite observations and ground-based measurements. Six dust events (DE) have been identified during the study period with average values of Aqua-MODIS AOD550 and Microtops-II AOD500 over Patiala as and , respectively while Aura-OMI AI exhibits high values ranging from 2.01 to 6.74. The Angstrom coefficients α380–870 and β range from 0.12 to 0.31 and 0.95 to 1.40, respectively. The measured spectral AODs, the OPAC-derived aerosol properties and the surface albedo obtained from MODIS were used as main inputs in SBDART model for the calculation of aerosol radiative forcing (ARF) over Patiala. The ARF at surface (SRF) and top of atmosphere (TOA) ranges from ~−50 to −100 Wm−2 and from ~−10 to −25 Wm−2, respectively during the maximum of dust storms. The radiative forcing efficiency was found to be −66 Wm−2AOD−1 at SRF and −14 Wm−2AOD−1 at TOA. High values of ARF in the atmosphere (ATM), ranging between ~

Structural Properties and Antimicrobial Activities of Polyalthia longifolia Leaf Extract-Mediated CuO Nanoparticles

Abstract: Herein, we report the eco-benevolent fabrication of copper oxide nanoparticles (CuONPs) by a green process using Polyalthia longifolia leaf extract (PLLE). Phytochemical screening for the PLLE evinced the existence of tannins, terpenoids, saponins, phenols, glycosides, and flavonoids. The produced CuONPs were explored by using XRD, zeta potential, DLS, EDAX, HRTEM, BET-surface area, UV-DRS, photoluminescence, and FTIR to ascertain its structural, morphological, and optical properties. Besides, these CuONPs evinced noteworthy bactericidal performance against Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Streptococcus pyogenes (S. pyogenes), and good antifungal performance against Aspergillus niger (A. niger), Epidermophyton floccosum (E. floccosum), Aspergillus clavatus (A. clavatus), and Candida albicans (C. albicans). The results indicated that the proactive eco-benign fabrication of CuONPs by sustainable “green chemistry” approaches can offer a convenient alternative to orthodox multi-step strategies for the creation of CuONPs.