Sharda University

About: Sharda University is a education organization based out in Greater Noida, Uttar Pradesh, India. It is known for research contribution in the topics: Computer science & Medicine. The organization has 1276 authors who have published 2012 publications receiving 16188 citations.

Efficient removal of heavy metals from artificial wastewater using biochar

Abstract: Increase environmental pollution, especially water contaminated with heavy metals has led to various problems in human life. Accumulation and magnification of heavy metals in human tissues through consumption of contaminated water can cause hazardous impacts on health. In the present study, bio-char was prepared from the shoot and root culture of in-vitro grown Plumbago zeylanica. Effect of bio-char (prepared from both the plant materials) on removal of chromium and cadmium from synthetic water was evaluated. Change in cadmium and chromium absorbance was recorded at every hour interval up to six hours using UV–Visible spectrophotometer. It was observed that after six-hour of incubation there was no further removal of heavy metals. Further optimization of different parameters such as concentration of heavy metal, solution pH and bio char concentration were performed. At 100 ppm concentration of heavy metals maximum removal was obtained. Furthermore, it was observed that pH 7 and 2 mg/ml bio char concentration showed maximum removal efficiency. The result showed that shoot derived bio char has more potential to remove cadmium and chromium as compared to the root derived bio char. In-vitro grown shoot culture provides an effective method to remove pollutants as it grows faster compared to wild type culture. Therefore, this method is useful for heavy metals removal from wastewater.

Treatment of complex nonunion of the shaft of the tibia using Ilizarov technique and its functional outcome.

Abstract: Background: A complex nonunion of the shaft of the tibia is a major cause of morbidity and mortality in patients with lower extremity injuries. Aims: The aim of this study was to evaluate the outcome of the functional and radiological outcome of complex nonunion shaft of tibia, treated by radical debridement, Ilizarov ring fixator with compression and distraction osteogenesis. Methods: From 2005 to 2010, sixty cases of complex nonunion shaft of tibia were included in our study. All infected nonunions were managed by radical debridement, fixed with Ilizarov ring fixator, monofocal/bifocal compression, and distraction osteogenesis. The average duration of follow-up is 36 months (26–50 months). The functional evaluation was done by using Association for the Study and Application of Methods of Ilizarov (ASAMI) scoring system and bone union with serial radiographs. Results: All patients had a successful union. The mean time for union was 7 months (5–9 months). The mean time of fixator removal is 12 months (8–14 months). Every patient had pin tract infections which were successfully treated with oral antibiotics. Four patients had an equinus deformity, one patient had insignificant limb shortening (1.5 cm), and three patients had soft tissue dystrophy. Using the ASAMI scoring system, we obtained 45 excellent, 10 good, 3 fair, and 2 poor functional results. Conclusions: The Ilizarov technique for complex nonunions has a high rate of success in achieving union and eradicating infection, bone loss, and malalignment. Radical debridement is the key step to control bone infection.

Nanoparticulate RNA delivery systems in cancer.

Abstract: Background Drug delivery system is a common practice in cancer treatment. RNA interference-mediated post-transcriptional gene silencing holds promise as an approach to knockdown in the expression of target genes responsible for cancer cell growth and metastasis. RNA interference (RNAi) can be achieved by delivering small interfering RNA (siRNA) and short hairpin RNA (shRNA) to target cells. Since neither interfering RNAs can be delivered in naked form due to poor stability, an efficient delivery system is required that protects, guides, and delivers the siRNA and shRNA to target cells as part of cancer therapy (chemotherapy). Recent findings In this review, a discussion is presented about the different types of drug delivery system used to deliver siRNA and shRNA, together with an overview of the potential benefits associated with this sophisticated biomolecular therapy. Improved understanding of the different approaches used in nanoparticle (NP) fabrication, along with an enhanced appreciation of the biochemical properties of siRNA/shRNA, will assist in developing improved drug delivery strategies in basic and clinical research. Conclusion These novel delivery techniques are able to solve the problems that form an inevitable part of delivering genes in more efficient manner and as part of more effective treatment protocols. The present review concludes that the nanoparticulate RNA delivery system has great possibility for cancer treatment along with several other proposed methods. Several NPs or nanocarriers are already in use, but the methods proposed here could fulfill the missing gap in cancer research. It is the future technology, which unravels the mystery of resolving genomic diseases that is, especially genomic instability and its signaling cascades.

A class of well-behaved generalized charged analogues of Vaidya-Tikekar type fluid sphere in general relativity

Abstract: In this paper first ever we have developed a class of well behaved charged fluid spheres expressed by a space time with its hypersurfaces $t = \operatorname {const}$ . as spheroid for the case 0

A Drug Repurposing Approach Towards Elucidating the Potential of Flavonoids as COVID-19 Spike Protein Inhibitors

Abstract: The novel coronavirus (nCoV) has emerged as a severe public health threat globally in the 21st century Several therapies were reported towards identifying ligand against coronavirus, including targeting specific functional proteins or enzymes that are crucial to viruses, thereby preventing the synthesis and replication of virus RNA Our study is mainly focused on targeting the virus's structural proteins, which could further block the binding of the virus to human cell receptors In our study, we have selected nine Flavonoids for the inhibition of COVID-19 Spike protein, which have already been reported with their antiviral efficacies against other virus-infected diseases AutoDock and PatchDock were used to study the inhibitory potential of flavonoids against COVID-19 Amongst all the eleven screened compounds, baicalin has depicted the highest binding affinity against 2019-nCoV spike glycoprotein Additionally, we have also compared its potential with two standard HIV drugs Abacavir and hydroxychloroquine, and the docking results clearly revealed the better inhibitory potential of baicalin in comparison to recently used drug Abacavir and hydroxychloroquine for the treatment of COVID-19 Therefore our experimental findings strongly suggested that baicalin can be used as a potential inhibitor against COVID-19 spike protein, which could inhibit the interaction of the virus with the host cell and thus could provide a potential lead molecule for the development of a drug against COVID-19 disease