SRM University

About: SRM University is a education organization based out in Chennai, India. It is known for research contribution in the topics: Computer science & Population. The organization has 10787 authors who have published 11704 publications receiving 103767 citations. The organization is also known as: Sri Ramaswamy Memorial University.

An automated learning model for sentiment analysis and data classification of Twitter data using balanced CA-SVM:

Abstract: The modern society runs over the social media for their most time of every day. The web users spend their most time in social media and they share many details with their friends. Such information ...

Association of serum and salivary tumor necrosis factor-α with histological grading in oral cancer and its role in differentiating premalignant and malignant oral disease.

Abstract: Background: Oral squamous cell carcinoma (OSCC) is an important malignancy throughout the world; early detection is an important criterion for achieving high cure rate. Out of the many reported markers for OSCC, this study validated the efficacy of tumor necrosis factor-α (TNF- α) in differentially diagnosing premalignant oral lesions and OSCC. Also, the study aimed to correlate the levels of salivary and serum TNFα with clinicopathologic factors. Materials and Methods: A prospective experimental laboratory study was designed. Serum and salivary samples from 100 subjects in each group of healthy control, premalignant disease (PMD) and OSCC were collected for the study following appropriate exclusion and inclusion criteria. Serum and salivary level of TNF-α was analysed by enzyme linked immunosorbent assay. The data obtained were subjected to appropriate statistical analysis. Results: Increased level of both serum and salivary TNF- α was observed in OSCC subjects compared to healthy control and PMD group. Receiver operator characteristic curve analysis and area under curve values showed high specificity and sensitivity for salivary TNF-α in differentiating OSCC from PMD and healthy controls. There was significant increase in TNF- α level in moderately and poorly differentiated lesion compared to well differentiated lesion and in stage IV of clinical stage. A positive correlation was observed only with histological grading of OSCC and TNF- α. Conclusions: Salivary TNF-α is proved to be superior for detecting OSCC. Increase in TNF-α with histological grading and clinical staging suggests a role in prognosis.

Synthesis of oleic acid coated iron oxide nanoparticles and its role in anti-biofilm activity against clinical isolates of bacterial pathogens

Abstract: In the present study, iron oxide nanoparticles (IONPs) were synthesized using the solvothermal method. The surface of the IONPs was modified with oleic acid (OA) and its role in anti-biofilm activity against clinical isolates of bacterial pathogens was studied. The physiochemical properties of OA-IONPs were characterized using vibrating sample magnetometer, X-ray diffraction, Fourier transform infrared, dynamic light scattering and scanning electron microscopy. The biofilm inhibitory effect of OA-IONPs was tested against Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa). The OA-IONPs showed a potent biofilm inhibitory effect in the case of Gram-positive bacteria and a less significant effect in Gram-negative bacteria. Further, enhanced biofilm inhibition was achieved against both the bacteria using external magnetic target and confirmed using fluorescence microscopy. In conclusion, OA-IONPs can be used as an effective surface modifier for biomaterials to prevent biofilm formation.