SRM University

About: SRM University is a education organization based out in Chennai, India. It is known for research contribution in the topics: Computer science & Population. The organization has 10787 authors who have published 11704 publications receiving 103767 citations. The organization is also known as: Sri Ramaswamy Memorial University.

Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial.

Abstract: The aim of this study was to compare the effectiveness of 2% articaine and 2% lignocaine in achieving adequate anesthesia in children between the age group of 6–13 years using inferior alveolar nerve block. A triple blinded randomized controlled trial was conducted in 180 participants (90 patients- 2% articaine, 90 patients-2% lignocaine). Effectiveness of the anesthetic agent was determined at 3 points determined by subjective evaluation of pain using pain scales (FPS-R). Paired sample t-test and chi square test were performed for statistical significance. Anesthetic success for 2% articaine were 64.4%, 42.2% and 81.8% respectively. The anesthetic success of 2% lignocaine was 66.7%, 48.9% and 85.7% at point one, point two and point three respectively (p > 0.05). This study concludes that 2% articaine in 1:2,00,000 did not demonstrate superior clinical effectiveness in comparison to 2% lignocaine. Lignocaine has always been considered the gold standard. With its unique chemical structure and increased potency, Articaine has been gaining popularity. Its efficacy in 2% concentration had not been compared to 2% lignocaine. 2% articaine did not show clinical superiority but its comparable effectiveness with lignocaine can encourage further research in using articaine in reduced concentrations to improve effectiveness.

A review on ZnO nanostructured materials: energy, environmental and biological applications.

Abstract: Zinc oxide (ZnO) is an adaptable material that has distinctive properties, such as high-sensitivity, large specific area, non-toxicity, good compatibility and a high isoelectric point, which favours it to be considered with a few exceptions. It is the most desirable group of nanostructure as far as both structure and properties. The unique and tuneable properties of nanostructured ZnO shows excellent stability in chemically as well as thermally stable n-type semiconducting material with wide applications such as in luminescent material, supercapacitors, battery, solar cells, photocatalysis, biosensors, biomedical and biological applications in the form of bulk crystal, thin film and pellets. The nanosized materials exhibit higher dissolution rates as well as higher solubility when compared to the bulk materials. This review significantly focused on the current improvement in ZnO-based nanomaterials/composites/doped materials for the application in the field of energy storage and conversion devices and biological applications. Special deliberation has been paid on supercapacitors, Li-ion batteries, dye-sensitized solar cells, photocatalysis, biosensors, biomedical and biological applications. Finally, the benefits of ZnO-based materials for the utilizations in the field of energy and biological sciences are moreover consistently analysed.

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

Abstract: For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types. Recently, it has been recognized that embryonic stem cells derived from both mice and humans exhibit two stable yet epigenetically distinct states of pluripotency: naive and primed. We now show that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in human embryonic stem cells (hESCs). Specifically, in naive hESCs, NNMT and its enzymatic product 1-methylnicotinamide are highly upregulated, and NNMT is required for low S-adenosyl methionine (SAM) levels and the H3K27me3 repressive state. NNMT consumes SAM in naive cells, making it unavailable for histone methylation that represses Wnt and activates the HIF pathway in primed hESCs. These data support the hypothesis that the metabolome regulates the epigenetic landscape of the earliest steps in human development.