SRM University

About: SRM University is a education organization based out in Chennai, India. It is known for research contribution in the topics: Computer science & Population. The organization has 10787 authors who have published 11704 publications receiving 103767 citations. The organization is also known as: Sri Ramaswamy Memorial University.

Fortified-Chain: A Blockchain-Based Framework for Security and Privacy-Assured Internet of Medical Things With Effective Access Control

Abstract: The rapid developments in the Internet of Medical Things (IoMT) help the smart healthcare systems to deliver more sophisticated real-time services. At the same time, IoMT also raises many privacy and security issues. Also, the heterogeneous nature of these devices makes it challenging to develop a common security standard solution. Furthermore, the existing cloud-centric IoMT healthcare systems depend on cloud computing for electrical health records (EHR) and medical services, which is not suggestible for a decentralized IoMT healthcare systems. In this article, we have proposed a blockchain-based novel architecture that provides a decentralized EHR and smart-contract-based service automation without compromising with the system security and privacy. In this architecture, we have introduced the hybrid computing paradigm with the blockchain-based distributed data storage system to overcome blockchain-based cloud-centric IoMT healthcare system drawbacks, such as high latency, high storage cost, and single point of failure. A decentralized selective ring-based access control mechanism is introduced along with device authentication and patient records anonymity algorithms to improve the proposed system’s security capabilities. We have evaluated the latency and cost effectiveness of data sharing on the proposed system using Blockchain. Also, we conducted a logical system analysis, which reveals that our architecture-based security and privacy mechanisms are capable of fulfilling the requirements of decentralized IoMT smart healthcare systems. Experimental analysis proves that our fortified-chain-based H-CPS needs insignificant storage and has a response time in the order of milliseconds as compared to traditional centralized H-CPS while providing decentralized automated access control, security, and privacy.

Biomimetic synthesis of silver nanoparticles from Streptomyces atrovirens and their potential anticancer activity against human breast cancer cells

Abstract: Silver nanoparticles (AgNPs) have been undeniable for its antimicrobial activity while its antitumour potential is still limited. Therefore, the present study focused on determining cytotoxic effects of AgNPs on Michigan cancer foundation-7 (MCF-7) breast cancer cells and its corresponding mechanism of cell death. Herein, the authors developed a bio-reduction method for AgNPs synthesis using actinomycetes isolated from marine soil sample. The isolated strain was identified by 16s ribotyping method and it was found to be Streptomyces atrovirens. Furthermore, the synthesised AgNPs were characterised by various bio-analytical techniques such as ultraviolet-visible spectrophotometer, atomic force microscopy, transmission electron microscopy, Fourier transform infra-red spectroscopy, and X-ray diffraction. Moreover, the results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay reveals 44.51 µg of AgNPs to have profound inhibition of cancer cell growth; furthermore, the inhibition of MCF-7 breast cancer cell line was found to be dose dependent on treatment with AgNPs. Acridine orange and ethidium bromide double staining methods were performed for cell morphological analysis. The present results showed that biosynthesised AgNPs might be emerging alternative biomaterials for human breast cancer therapy.