Showing papers by "University of Alabama published in 1980"
TL;DR: The International Association for Correctional and Forensic Psychology (IA4cfp) as mentioned in this paper published a survey of the state-of-the-art work on forensic psychology in the criminal justice domain.
Abstract: Official Publication of the International Association for Correctional and Forensic Psychology www.ia4cfp.org Philip R. Magaletta, Federal Bureau of Prisons Douglas B. Marlowe, University of Pennsylvania Mary McMurran, University of Nottingham, UK Edwin I. Megargee, Florida State University Holly A. Miller, Sam Houston State University Robert Morgan, Texas Tech University David Nussbaum, University of Toronto Scarborough; Ontario Shores, Whitby Randy Otto, University of South Florida Christina A. Pietz, U.S. Medical Center for Federal Prisoners Devon Polaschek, Victoria University of Wellington Richard E. Redding, Chapman University Marnie E. Rice, Waypoint Centre for Mental Health Care Richard Rogers, University of North Texas R. Barry Ruback, Pennsylvania State University Randall T. Salekin, University of Alabama Jeffrey Sandler, Research Foundation for Mental Hygiene David J. Simourd, Aces Inc., Kingston, Ontario Brent Snook, Memorial University of Newfoundland Tony Toneatto, University of Toronto Glenn D. Walters, Kutztown University Jennifer Wareham, Wayne State University Stephen Wormith, University of Saskatchewan Michael G. Aamodt, Radford University Curt R. Bartol, Glenville, New York Kevin M. Beaver, Florida State University Craig Bennell, Carleton University Guy Bourgon, Public Safety Canada Stanley L. Brodsky, University of Alabama Barry R. Burkhart, Auburn University David DeMatteo, Drexel University Naomi J. Freeman, New York State Office of Mental Health David S. Glenwick, Fordham University Alan M. Goldstein, John Jay College of Criminal Justice J. Thomas Grisso, University of Massachusetts R. Karl Hanson, Public Safety Canada Robert D. Hare, University of British Columbia Kirk Heilbrun, Drexel University Jaime Henderson, Temple University Robert Homant, University of Detroit–Mercy Kayleen Islam-Zwart, Eastern Washington University J. B. Kingree, Clemson University Calvin M. Langton, University of Toronto Arthur J. Lurigio, Loyola University BOOK REVIEW EDITOR: Joseph Eastwood ASSOCIATE EDITOR: Jody L. Sundt MANAGING EDITOR: Margaret J. Freeland Braun EDITORIAL ASSISTANT: Breanna Schlingheyde FOUNDING EDITOR: Stanley L. Brodsky
903 citations
336 citations
TL;DR: It is still not clear how many patients can be salvaged by treatment to extended paraaortic radiation fields, but longer periods of follow-up in patients whose treatment plans were based on surgical staging information will be required.
296 citations
TL;DR: Evidence of enhanced sympathetic activity during surgery may be a useful predictor of the development of postoperative hypertension, particularly in patients with a longer history of angina of greater severity.
Abstract: A prospective study of hypertension first appearing during and after saphenous vein bypass coronary surgery was performed in 28 patients to examine the incidence, hemodynamics and mechanism of this problem In 15 patients (54 percent) new hypertension developed (mean arterial pressure greater than 107 mm Hg), characterized by increased peripheral vascular resistance and unchanged cardiac output within 1 hour after surgery These 15 patients had a longer history of angina of greater severity, but also had relatively well preserved ventricular myocardium Because plasma renin activity was depressed in patients in the hypertensive group, activation of the renin-angiotensin system was not important in the pathogenesis of this postoperative hypertension The expected decrease in total peripheral resistance at the onset of cardiopulmonary bypass was observed in all patients, but later during bypass the peripheral resistance increased in all patients in association with a rise in plasma epinephrine levels Patients who had hypertension postoperatively had a greater increase in arterial pressure and total peripheral resistance during cardiopulmonary bypass than did those with normal postoperative blood pressure An elevation in plasma epinephrine and norepinephrine concentration, suggesting enhanced sympathoadrenal responsiveness to the challenge of cardiopulmonary bypass, was characteristic of the hypertensive group This evidence of enhanced sympathetic activity during surgery may be a useful predictor of the development of postoperative hypertension
174 citations
TL;DR: The topic of this panel was suggested by Dr. Richard C. Boronow, the president presiding over the 1979 meeting of the Society of Gynecologic Oncologists, and Dr. William H. Morrow as discussed by the authors.
162 citations
TL;DR: It is indicated that a substantial loss of renal hemodynamic responsiveness follows ischemic injury to the dog even when RBF is maintained within the normal range, consistent with a role for tubular flow in the normal mechanism of autoregulation.
121 citations
TL;DR: Thallium-201 exercise myocardial scintigraphy is a safe, useful, noninvasive tool for identifying patients with MVCAD and residual JEP and is much more reliable than clinical findings during convalescence after MI.
Abstract: SUMMARY
The usefulness of thallium-201 (Tl-201) exercise myocardial scintigraphy in identifying patients with multivessel coronary artery disease (MVCAD) and residual jeopardized myocardium after myocardial infarction (MI) was evaluated in 32 patients 3 weeks after MI. All patients underwent 1) limited multilead submaximal treadmill testing, 2) thallium-201 (TI) myocardial scintigraphy at end-exercise and at rest, and 3) coronary and left ventricular angiography.
TI-201 perfusion defects were categorized as either reversible (ischemia) or irreversible (scar). The conventional exercise test was designated positive if there was ST depression 2 1 mm and/or angina. Jeopardized myocardium (JEP) was defined angiographically as a segment of myocardium with normal or hypokinetic wall motion supplied by a significantly stenotic major coronary artery. MVCAD was defined as two or more significantly stenotic coronary arteries. “Significant” coronary stenosis was categorized as either 50–69% diameter narrowing or 2 70% diameter narrowing, thereby yielding, respectively, two subgroups each of jeopardized myocardium (JEP-50 and JEP-70) and MVCAD (MV-S0 and MV-70).
Clinical findings of angina, heart failure or ventricular arrhythmias during the late convalescent period after MI occurred in four of 10 patients (40%) with MV-50, five of 16 (31%) with MV-70, four of 10 (40%) with JEP-50 and five of 18 (28%) with JEP-70, and thus were insensitive for detecting MVCAD and JEP.
Reversible ischemia and/or a positive conventional exercise test occurred in five of 10 patients (50%) with MV-50, 13 of 16 (81%) with MV-70, four of 10 (40%) with JEP-S0 and 15 of 18 (83%) with JEP-70. All eight patients with both TI-201 reversible ischemia and a positive conventional exercise test had JEP-70. In 30 of 31 patients (97%) with angiographic asynergy, TI-201 scar was detected. No complications were associated with exercise testing.
Thus, 3 weeks after MI, Tl-201 exercise myocardial scintigraphy is a safe, useful, noninvasive tool for identifying patients with MVCAD and residual JEP and is much more reliable than clinical findings during convalescence after MI.
117 citations
TL;DR: The finding that the attitudes of the Family Practice residents improved from the first year through the third year of residency is the first medical specialty group to demonstrate such a trend.
Abstract: For the Family Practitioner, elderly patients are a highly significant group. In the past, some health professionals have expressed negative attitudes toward the elderly. Thus a need exists to study specific factors that may influence a Family Practice resident's willingness to treat older patients. A Likert-type questionnaire was developed that utilized the Thurstone-Likert discrimination technique. Five categories were chosen for study: general attitudes, cost effectiveness, time and energy, therapeutic potential, and educational preparation. Responses of 150 Family Practice residents were then analyzed. The attitudes of the residents were significantly positive in all categories except Educational Preparation. Noteworthy was the finding that the attitudes improved from the first year through the third year of residency. This is the first medical specialty group to demonstrate such a trend. Certain negative attitudes observed in the Educational Preparation category re-emphasize the need for training programs to improve professional geriatric instruction.
88 citations
TL;DR: The hypothesis that stuttering may be a linguistic segmentation dysfunction is presented and the findings are discussed in terms of possible variables affecting hemispheric processing in normal males, females, and stutterers.
Abstract: The alpha hemispheric asymmetries of normal-speaking males, normal-speaking females and male stutterers were examined with electroencephalographic (EEG) techniques during exposure to connected spee...
86 citations
TL;DR: The diamagnetic salts, CsMgBr 3, CsCdBr 3 and CsmgI 3, were shown by X-ray diffraction studies to adopt the CsNiCl 3 structure.
86 citations
TL;DR: It is demonstrated that multivessel coronary artery disease is common in survivors of myocardial infarction and is suggested by the occurrence of post-infarction angina and by the history of an antecedent myocardIAL infarctions.
TL;DR: Observed abnormalities in the amount and pattern of incorporation of 2-3H-myo-inositol into diabetic nerve phospholipids could be explained, in part, by decreased activities of CDP-diglyceride: inositol transferase and phosphatidylinositl 4-phosphate kinase activities in the diabetic nerves.
Abstract: The metabolism of myo -inositol and its hospholipids has been studied in the sciatic nerves of control, two weeks9 streptozotocin-diabetic, and insulin-treated diabetic rats. The concentrations of glucose, fructose, and sorbitol were increased and the concentration of myo -inositol was decreased in the sciatic nerves of the diabetic animals; these abnormalities were only partially corrected by insulin therapy that was adequate to obviate hyperglycemia. Whereas the space of distribution of 2- 3 H- myo -inositol was found to exceed the total water space of the nerves of control animals, the 2- 3 H- myo -inositol space approximated the water space in the nerves of diabetic animals and was only slightly increased after insulin therapy. During the first 2 h after the intraperitoneal injection of 2- 3 H- myo -inositol, the recovery of radioactivity in nerve lipids was decreased by 69% in the untreated diabetics and by 77% in the insulin-treated diabetics. Analysis of the individual phosphoinositides revealed a proportional increase in the radioactivity recovered with phosphatidylinositol and a decrease in the recovery with triphosphatidylinositol in the diabetic nerves. CDP-diglyceride:inositol transferase activity was decreased by 44% in homogenates of sciatic nerves from untreated diabetic rats, but it was normal in nerve homogenates from insulin-treated diabetics. The pattern of incorporation of radioactivity into phospholipids after 1 h of incubation of nerve homogenates with 2- 3 H- myo -inositol was similar to that observed in vivo. The fractional recovery of radioactivity with phosphatidylinositol was increased, whereas the recovery of label as triphosphatidylinositol was decreased by 11% in the presence of homogenates of sciatic nerves from diabetic rats. These observations indicate that 2 wk of acute streptozotocin diabetes results in a decrease in the sciatic nerve content and space of distribution of myo -inositol and suggests that nerve myo -inositol transport may be defective in the diabetic animal. The observed abnormalities in the amount and pattern of incorporation of 2- 3 H- myo -inositol into diabetic nerve phospholipids could be explained, in part, by decreased activities of CDP-diglyceride:inositol transferase and phosphatidylinositol 4-phosphate kinase activities in the diabetic nerves. However, the fact that the incorporation of 2- 3 H- myo -inositol into phospholipids was decreased in the nerves of insulin-treated—diabetic animals despite a normal CDP-diglyceride:inositol transferase activity suggests that defective myo -inositol transport may also contribute to the abnormal neural phosphoinositide metabolism in this model. The possibility that these abnormalities are related to the development of the structural and functional changes associated with diabetic neuropathy requires further investigation.
TL;DR: Vidarabine is the first drug to become generally available in the USA for parenteral treatment of life-threatening or debilitating herpes simplex virus infections of man and it is demonstrated that the drug was at least as effective for healing as idoxuridine and trifluorothymidine.
Abstract: Synopsis:Vidarabine2 is the first drug to become generally available in the USA for parenteral treatment of life-threatening or debilitating herpes simplex virus infections of man. For the past decade laboratory and clinical studies have been in progress to assess the pharmacology of the compound, its mechanism of action and its potential usefulness in clinical investigations. Currently, clinical usefulness has been established for herpes simplex infections of the eye and brain. Further studies in progress are evaluating the drug’s ability to prevent progressive disease from herpes zoster in the immunocompromised patient, reduce mortality and morbidity from neonatal herpes simplex virus infection and improve outcome of chronic hepatitis B infection. Pharmacology: Vidarabine is a purine nucleoside derivative developed specifically for therapy of life-threatening or severely debilitating human herpesvirus infections. In vitro, herpes simplex and varicella-zoster viruses are the most sensitive to drug; however, cytomegalovirus and Epstein Barr virus can be inhibited to some extent. Pharmacokinetic Studies: Peak plasma concentrations following a continuous 12-hour infusion of vidarabine at standard dosages of 10 to 15mg/kg/day are approximately 3 to 8μg/ml of arabinosyl hypoxanthine (the primary metabolite, formed by deamination) and about 0.2μg/ml of vidarabine. Arabinosyl hypoxanthine has antiviral activity, although less than the parent drug. It is found in the cerebrospinal fluid at a concentration of about one-third the plasma concentration. Topically applied vidarabine does not penetrate the anterior chamber of the eye to a significant extent, and this form of therapy is thus unsuitable for ‘deep’ eye infections. The kidney is the primary route of clearance. The drug and its metabolites can be found intracellularly for periods of up to several weeks following administration, although there is no evidence that extracellular accumulation occurs. Therapeutic Trials: Trials have been conducted for topical treatment of herpetic eye infections and with parenteral administration for herpes zoster and herpes simplex encephalitis. Topical treatment of herpes keratoconjunctivitis with 3 % vidarabine have demonstrated that the drug was at least as effective for healing as idoxuridine and trifluorothymidine. Importantly, many patients who experienced adverse effects because of idoxuridine administration (oedema, pain, burning, further injection) demonstrated prompt healing when switched to vidarabine. Similarly, parenteral vidarabine therapy appeared beneficial for uveal tract infection with herpes simplex virus. Parenteral trials of vidarabine have been conducted or are underway for herpes zoster in immunocompromised patients and herpes simplex encephalitis, neonatal herpes and chronic hepatitis B infections. In addition, small numbers of patients with progressive mucocutaneous herpes simplex and cytomegalovirus infections have received vidarabine. Only studies of herpes zoster and herpes simplex encephalitis have been completed to date. In these 2 diseases drug therapy had a beneficial effect on the disease course. Patients having herpes zoster who received treatment had accelerated clearance of virus from lesions, time to total pustulation and decreased new lesion formation. Pain was similarly qualitatively reduced at significant levels. Variables found to influence the healing process included the type of underlying disease, (lymphoproliferative malignancy versus other diseases requiring immunosuppressive therapy), age and duration of infection. Treatment of brain biopsy-proven herpes simplex encephalitis resulted in a statistically significant reduction in mortality from 70% (placebo) to 28 % 30 days following the onset of therapy. The level of consciousness at the time of brain biopsy and time to initiation of treatment were the major determinants of outcome with vidarabine treatment. Delaying therapy until coma ensues is associated with higher mortality and severe morbidity. Nearly 40 % of treated patients returned to an ‘adequate’ existence with 22% completely normal following therapy. The findings from this study of 28 patients have been verified in an additional 75 biopsy-proven and treated individuals in an open study. Completion of investigations of neonatal herpes simplex virus infection and herpes zoster may further expand the clinical usefulness of this drug. Side Effects: Intravenous administration of the drug at 10 to 15mg/kg/day for 5 to 10 days is associated with few adverse experiences if the patient has neither hepatic nor renal function compromised. Nausea, vomiting and/or diarrhoea occur in approximately 10 to 15 percent of all patients. Bone marrow toxicity is not apparent at these dosages but can be found with regularity if the dosage exceeds 25 to 30mg/kg/day. Dosage: Vidarabine is usually administered at a dosage of 15 mg/kg/day, by intravenous infusion only. Because of its low solubility, it should be dissolved in standard intravenous fluids in such a way so as not to exceed a vidarabine concentration of 450mg/L. For herpes simplex encephalitis the recommended duration of therapy is 10 days.
TL;DR: The sequence of events suggests that laryngospasm precipitated the development of the pulmonary edema in this patient.
TL;DR: Over the medium term, the porcine bioprosthesis compared favorably with mechanical prostheses in terms of survival, function, and thromboembolism.
TL;DR: Since there is no association in the general population between a woman's glutamate-pyruvate transaminase genotype and her cancer risk, the glutamate- pyruvatespecifictransaminase linkage cannot be used as a screening test for breast cancer.
Abstract: The patterns of the occurrence of breast cancer in 11 high-risk families were evaluated by segregation and linkage analysis. These patterns were consistent with the hypothesis that increased susceptibility to breast cancer was inherited as an autosomal dominant allele with high penetrance in women. The postulated susceptibility allele in these families may be chromosomally linked to the glutamate-pyruvate transaminase (E.C. 2.6.1.2, alanine aminotransferase) locus. Confirmation of this linkage in other families would establish the existence of a gene increasing susceptibility to breast cancer. Since there is no association in the general population between a woman9s glutamate-pyruvate transaminase genotype and her cancer risk, the glutamate-pyruvate transaminase linkage cannot be used as a screening test for breast cancer.
TL;DR: It is demonstrated that a subjective state of deIndividuation mediates the effect of deindividuating situational cues on aggression displayed by small groups of coacting aggressors.
Abstract: This experiment demonstrated that a subjective state of deindividuation mediates the effect of deindividuating situational cues on aggression displayed by small groups (n = 4) of coacting aggressors. The deindividuated state was composed of two factors, Self-Awareness and Altered Experiencing, both of which had a causal influence on aggressive behavior. These data are interpreted in terms of deindividuation theories which assume that certain input variables reduce self-awareness and concern about social evaluation and thereby weaken the restraints against expressing antisocial behavior. Also as predicted, compared with a no-model control condition, a high-aggressive model disinhibited overt displays of aggression, whereas a low-aggressive model inhibited aggression among both individuated and deindividuated group members. Language: en
TL;DR: Sural nerve biopsy revealed marked axonal degeneration of myelinated as well as unmyelinated fibers, which represents a widespread acute ganglionopathy of unknown cause.
Abstract: A previously well 9-year-old boy developed acute autonomic and sensory neuropathy. Recovery was incomplete over a thirteen-month period. Spinal fluid protein was increased during the acute phase. Sensory nerve potentials were absent in the presence of normal motor and mixed nerve conduction velocities. Sural nerve biopsy revealed marked axonal degeneration of myelinated as well as unmyelinated fibers. This case represents a widespread acute ganglionopathy of unknown cause.
TL;DR: A laboratory study was conducted to investigate the task performance of Type A coronary-prone individuals relative to Type B's in three types of social situations: alone, with a similarly performing coactor, or with a better-performing coactor.
Abstract: A laboratory study was conducted to investigate the task performance of Type A coronary-prone individuals relative to Type B's in three types of social situations: alone, with a similarly performing coactor, or with a better-performing coactor. The results indicate that Type A's performance on a simple task was facilitated by the presence of either a similar or superior coactor, whereas the presence of coactors impaired performance on a complex task. Type B's showed weak and nonsignificant facilitation effects that occurred only in the presence of similar coactors. The results are discussed in terms of the Type A's concern about evaluation, achievement, and social comparison, and Sanders and Baron's distraction-conflict theory of social facilitation.
TL;DR: In this article, the authors compare the peer status of learning disabled children served in mainstream programs with their nonlearning disabled peers and explore the relationship of teacher preference and social status among children, and the accuracy of self-appraisal of social status for learning disabled and non-learning disabled students.
Abstract: Social integration, one aspect of mainstreaming, has become an increasing concern with educators working with learning disabled students. Previous results generally have indicated a low peer status for learning disabled students. The purpose of this study was to compare the peer status of learning disabled children served in mainstream programs with their nonlearning disabled peers and to explore (1) the relationship of teacher preference and social status among children, and (2) the accuracy of self-appraisal of social status among learning disabled and nonlearning disabled students. Findings concerned with peer status were similar to previous research. In addition, learning disabled students were found to be less preferred by teachers. A significant relationship between teacher preference and social status was observed in 78% of the classrooms. Results for self-appraisal of social status were somewhat different from previous research. Implications for research, curriculum, and teacher education are disc...
TL;DR: Remarkable clinical improvement followed corticosteroid treatment and inexcitability of the distal portion of the peroneal and posterior tibial nerves and minimal reduction in amplitude of the muscle potential are shown.
Abstract: A 58-year-old patient had subacute polyneuropathy. Electrophysiological studies showed inexcitability of the distal portion of the peroneal and posterior tibial nerves and minimal reduction in amplitude of the muscle potential with minimal slowing in motor nerve conduction velocity. The sural nerve biopsy showed multiple sarcoid granulomas in the epineurial and perineurial spaces, periangiitis and panangiitis, and axonal degeneration. Remarkable clinical improvement followed corticosteroid treatment.
TL;DR: In this article, the frequency, characteristics, and complications of mural thrombi found at surgery, and to determine what effect chronic anticoagulation might have had upon the clinical course of these patients.
TL;DR: The utility of ion nuclear magnetic resonance to determine rate constants relevant to transport through the gramicidin channel and of the Eyring rate theory to introduce voltage dependence is demonstrated.
Abstract: Malonyl gramicidin is incorporated into lysolecithin micelles in a manner which satisfies a number of previously demonstrated criteria for the formation of the transmembrane channel structure. By means of sodium-23 nuclear magnetic resonance, two binding sites are observed: a tight site and a weak site with binding constants of approximately 100m
−1 and 1m
−1, respectively. In addition, off-rate constants from the two sites were estimated from NMR analyses to bek
off
≃3×105/sec andk
off
≃2×107/sec giving, with the binding constants, the on-rate constants,k
on
≃3×107/msec andk
on
≃2×107/m sec. Five different multiple occupancy models with NMR-restricted energy profiles were considered for the purpose of calculating single-channel currents as a function of voltage and concentration utilizing the four NMR-derived rate constants (and an NMR-limit placed on a fifth rate constant for intrachannel ion translocation) in combination with Eyring rate theory for the introduction of voltage dependence. Using the X-ray diffraction results of Koeppe et al. (1979) for limiting the positions of the tight sites, the two-site model and a three-site model in which the weak sites occur after the tight site is filled were found to satisfactorily calculate the experimental currents (also reported here) and to fit the experimental currents extraordinarily well when the experimentally derived values were allowed to vary to a least squares best fit. Surprisingly the “best fit” values differed by only about a factor of two from the NMR-derived values, a variation that is well within the estimated experimental error of the rate constants. These results demonstrate the utility of ion nuclear magnetic resonance to determine rate constants relevant to transport through the gramicidin channel and of the Eyring rate theory to introduce voltage dependence.
TL;DR: Ten patients with complete atrioventricular (AV) canal and tetralogy of Fallot or double-outlet right ventricle (DORV) with subaortic ventricular septal defect and pulmonary stenosis underwent complete repair.
TL;DR: The results indicate that B cells programmed to produce IgM RF are present in both normal and RA B cell repertoires, but are preferentially expressed in RA.
Abstract: Peripheral blood mononuclear leukocytes (MNL) from 42 patients with classic/definite seropositive rheumatoid arthritis (RA) and 24 healthy adult controls were tested for their capacity to produce IgM rheumatoid factor (RF) in vitro in the presence and absence of pokeweed mitogen (PWM). In no instance was spontaneous elaboration of IgM RF from control MNL observed. In contrast, MNL from 16 of the 42 RA patients spontaneously synthesized IgM RF (22 +/- 43 ng/culture) which constituted a substantial fraction of the total IgM in these culture fluids (48 +/- 26%). Pokeweed mitogen induced detectable quantities of IgM RF in MNL culture supernatants from 10 of 24 controls (12 +/- 11 ng/culture) and 33 of 42 RA patients (60 +/- 82 ng/culture, P = 0.008). IgM RF constituted a significantly higher proportion of the total IgM in RA MNL supernatants than in control supernatants (11 +/- 11% versus 1.01 +/- 1.03%; P = 0.013). IgM RF production (spontaneous and PWM-induced) was dependent upon de novo protein synthesis. The results indicate that B cells programmed to produce IgM RF are present in both normal and RA B cell repertoires, but are preferentially expressed in RA.
TL;DR: In this study radiographs underexposed by a factor of three with a scanning multiple slit assembly (SMSA) were enhanced autoradiographically and found visually to contain more information than properly exposed radiographs obtained under similar conditions using a conventional Bucky grid.
Abstract: If a normal screen-film exposure is made using a conventional grid, a reduced exposure may be used with a superior scatter removal device to record the same image information. This theoretical conclusion is not readily demonstrated because of the limited visibility on the underexposed film. In this study radiographs underexposed by a factor of three with a scanning multiple slit assembly (SMSA) were enhanced autoradiographically and found visually to contain more information than properly exposed radiographs obtained under similar conditions using a conventional Bucky grid. This observation was confirmed by contrast scale and noise measurements. Furthermore, the entrance skin exposure of the radiograph using the SMSA was 45% of that required with the grid technique at the same beam quality.
TL;DR: A solid-phase radioimmunoassay capable of detecting nanogram quantities of human IgM rheumatoid factor (RF) in biologic fluids has been developed and should permit investigation of the cellular mechanisms underlying RF production.
Abstract: A solid-phase radioimmunoassay capable of detecting nanogram quantities of human IgM rheumatoid factor (RF) in biologic fluids has been developed. Binding curves for monoclonal IgM RF and polyclonal IgM rheumatoid factors were similar under the conditions utilized for the assay. Human IgG did not interfere with the detection of IgM RF by this method. Small quantities (less than or equal to 0.2%) of nonspecific binding by nonRF IgM to the human IgG coated tubes utilized in the assay were corrected for by assaying samples in parallel bovine serum albumin coated control tubes. As expected, patients with seropositive rheumatoid arthritis (RA) had significantly higher concentrations of IgM RF than seronegative RA patients (mean +/- 1 SD = 652 +/- 553 microgram/ml versus 11.3 +/- 13.3 microgram/ml, P less than 0.001). In contrast, all normal control sera assayed to date contained less than 0.1 microgram/ml of IgM RF. The capacity of the assay to detect nanogram quantities of IgM RF should permit investigation of the cellular mechanisms underlying RF production.
TL;DR: The decrease in hospital mortality rate with time and the neutralization of young age and multiplicity of VSDs as important incremental risk factors resulted from improvements such as more precise preoperative diagnosis of location and number of V SDs and improved intraoperative and postoperative care.
TL;DR: In this article, the reaction of a 1/1 mole ratio of GdCl3 and NaC5H5 in THF resulted in the formation of (η5-C 5H5)3Gd · THF.
TL;DR: Growth curve analysis for both complete and incomplete data structures is reviewed in this article, where specific attention is paid to the incomplete data model of Kleinbaum and its applicability to the mixed longitudinal study.
Abstract: Growth curve analysis is reviewed for both complete and incomplete data structures. Specific attention is paid to the incomplete data model of Kleinbaum and its applicability to the mixed longitudinal study. Design considerations and efficiency for various incomplete longitudinal studies are also discussed.