University of Arkansas for Medical Sciences

About: University of Arkansas for Medical Sciences is a education organization based out in Little Rock, Arkansas, United States. It is known for research contribution in the topics: Population & Health care. The organization has 14077 authors who have published 26012 publications receiving 973592 citations. The organization is also known as: UAMS.

Moderate drug use and delay discounting: a comparison of heavy, light, and never smokers.

Abstract: Delay discounting was examined in light smokers (10 or fewer cigarettes per day) and compared with previously published delay discounting data for heavy and never smokers. Participants evaluated several hypothetical outcomes: money gains and loses ($10, $100, and $1,000), health gains and losses (durations of improved and impoverished health subjectively equivalent to $1,000), cigarette gains and losses (amounts subjectively equivalent to $1,000), and potentially real rewards ($10 and $100). Light smokers discounted money significantly more than never smokers, but light smokers did not differ from heavy smokers. The 3 groups did not statistically differ in discounting of health consequences. Similarly, the 2 smoking groups were not found to differ in discounting of cigarettes. Like heavy smokers, light smokers discounted cigarettes significantly more than money and health. Several significant, positive correlations were found between smoking rate and various discounting measures in the heavy smokers but not in the light smokers. Several previous findings were replicated, helping to validate the present results: the sign effect (greater discounting of gains than losses), the magnitude effect (greater discounting of smaller rewards), reliability of discounting measures over time, and the consistency of hypothetical and potentially real rewards. These data suggest that even moderate levels of drug use may be associated with high delay discounting levels.

Benzodiazepines and the risk of falls in nursing home residents.

Abstract: CONTEXT: For nursing home residents who require a benzodiazepine, short-acting agents are recommended, primarily to avoid increased risk of falls and other injuries associated with the long-acting agents. However, much of the data for the clinical outcomes of falls and injuries comes from community-dwelling older people. OBJECTIVE: To quantify the rate of falls among nursing home residents taking benzodiazepines and how this varies with drug elimination half-life. DESIGN: Historical cohort study. POPULATION: A total of 2510 residents of 53 Tennessee nursing homes, classified according to benzodiazepine use on each day of follow-up. OUTCOME MEASURES: Falls occurring during study follow-up. RESULTS: After adjustment for differences in resident characteristics, benzodiazepine users had a 44% increased rate of falls (adjusted rate ratio 1.44 [95% confidence interval, 1.33-1.56]). The adjusted rate ratio increased from 1.30 (1.12-1.52) for a dose equivalent to ≤2 mg of diazepam, to 2.21 (1.89-2.60, P 8 mg. The rate of falls was greatest in the 7 days after the benzodiazepine was started (rate ratio of 2.96 [2.33-3.75]) but remained elevated (1.30 [1.17-1.44]) after the first 30 days of therapy. Drugs with elimination half-lives of < 12, 12–23, and ≥24 hours had adjusted rate ratios of 1.15 (0.94-1.40), 1.45 (1.33-1.59), and 1.73 (1.40-2.14), respectively. Users of hypnotics with elimination half-lives < 12 hours had an increased rate of falls occurring during the night (adjusted rate ratio 2.82 [2.02–3.94]). CONCLUSIONS: Although the risk of falls among nursing home residents receiving short-acting benzodiazepines is less than that for the long-acting agents, these drugs are associated with a materially increased risk of nocturnal falls. J Am Geriatr Soc 48:682–685, 2000.

Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservation.

Abstract: Background Variations in arm lymphatic drainage put the arm lymphatics at risk for disruption during axillary lymph node surgery. Mapping the drainage of the arm with blue dye (axillary reverse mapping, ARM) decreases the likelihood of disruption of lymphatics and subsequent lymphedema.