Institution
University of Milano-Bicocca
Education•Milan, Italy•
About: University of Milano-Bicocca is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Population & Blood pressure. The organization has 8972 authors who have published 22322 publications receiving 620484 citations. The organization is also known as: Università degli Studi di Milano-Bicocca & Universita degli Studi di Milano-Bicocca.
Papers published on a yearly basis
Papers
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TL;DR: This study presents the first‐time prospective application of a deep learning model for designing new druglike compounds with desired activities and synthesized five top‐ranking compounds designed by the generative model.
Abstract: Generative artificial intelligence offers a fresh view on molecular design. We present the first-time prospective application of a deep learning model for designing new druglike compounds with desired activities. For this purpose, we trained a recurrent neural network to capture the constitution of a large set of known bioactive compounds represented as SMILES strings. By transfer learning, this general model was fine-tuned on recognizing retinoid X and peroxisome proliferator-activated receptor agonists. We synthesized five top-ranking compounds designed by the generative model. Four of the compounds revealed nanomolar to low-micromolar receptor modulatory activity in cell-based assays. Apparently, the computational model intrinsically captured relevant chemical and biological knowledge without the need for explicit rules. The results of this study advocate generative artificial intelligence for prospective de novo molecular design, and demonstrate the potential of these methods for future medicinal chemistry.
235 citations
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TL;DR: In this article, the authors investigated the impact of an observation framework on preservice teachers' abilities to engage in productive video-based reflections on mathematics teaching and found that the Lesson Analysis Framewo...
Abstract: This study investigates the impact of an observation framework on preservice teachers’ abilities to engage in productive video-based reflections on mathematics teaching. The Lesson Analysis Framewo...
234 citations
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TL;DR: In this article, the authors present an innovative attempt to evaluate sustainability holistically, by defining specific targets through the definition of indicators suitable to measure and evaluate the temporal evolution of development policies, mainstreaming sustainability to reduce adverse effects on the environment and promoting conservation of local and traditional values.
233 citations
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TL;DR: This article summarizes current knowledge on short-term (within the 24 hours) and long-term BP variability and discusses the relationship of BP variability with BP mean values in absence and during antihypertensive treatment, and the prognostic significance ofBP variability.
Abstract: It has long been known that blood pressure (BP) is characterized by an array of spontaneous variations.1 That is, BP values vary markedly within the 24 hours because of day-night changes but also because of differences among hours, minutes, and even adjacent beats. They also show variations over more prolonged periods because of differences among days, months, and seasons,2 also with a trend for systolic BP to increase over the years and for diastolic BP to display an age-related biphasic change.3
This article summarizes current knowledge on short-term (within the 24 hours) and long-term BP variability. Mention will be made of the following: (1) factors responsible for BP variations and mechanisms through which they occur; (2) the relationship of BP variability with BP mean values in absence and during antihypertensive treatment; and (3) the prognostic significance of BP variability. Current limitations of the studies on BP variability will be also discussed to emphasize what future studies should address.
### Factors and Mechanisms
A large body of evidence shows that, over the 24 hours, BP undergoes marked variations in response to physical activity, sleep, and emotional stimuli of various nature and duration, thereby documenting the profound involvement of behavioral influences on BP variability. However, spontaneous BP variations also occur independently on behavior. For example, throughout the day and night, BP oscillates regularly at different frequencies, presumably because of influences originating within the brain.4 Furthermore, BP varies more or less regularly in response to the mechanical forces generated by ventilation and also shows irregular nonbehaviorally and nonmechanically related changes with a possible origin from humoral influences and even local vasomotor phenomena. Finally, BP variations are opposed throughout the 24 hours by the baroreflex, which makes the magnitude of 24-hour BP variability in a given individual the net effect of pro-oscillatory and antioscillatory …
232 citations
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Newcastle University1, Newcastle upon Tyne Hospitals NHS Foundation Trust2, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico3, National and Kapodistrian University of Athens4, University of Adelaide5, Nottingham University Hospitals NHS Trust6, University of Cambridge7, University of Helsinki8, University of Bern9, University of Milano-Bicocca10, Linköping University11, University of Antwerp12, University of Palermo13, University of Turin14, University of Paris15, University of Mainz16
TL;DR: This study confirms PNPLA3 as a risk factor for the full histological spectrum of NAFLD at genome-wide significance levels, with important contributions from TM6SF2 and HSD17B13 and PYGO1 is a novel steatosis modifier, suggesting relevance of Wnt signalling pathways inNAFLD pathogenesis.
232 citations
Authors
Showing all 9226 results
Name | H-index | Papers | Citations |
---|---|---|---|
Carlo Rovelli | 146 | 1502 | 103550 |
Giuseppe Mancia | 145 | 1369 | 139692 |
Marco Bersanelli | 142 | 526 | 105135 |
Teruki Kamon | 142 | 2034 | 115633 |
Marco Colonna | 139 | 512 | 71166 |
M. I. Martínez | 134 | 1251 | 79885 |
A. Mennella | 132 | 463 | 93236 |
Roberto Salerno | 132 | 1197 | 83409 |
Federico Ferri | 132 | 1376 | 89337 |
Marco Paganoni | 132 | 1438 | 88482 |
Arabella Martelli | 131 | 1318 | 84029 |
Sandra Malvezzi | 129 | 1326 | 84401 |
Andrea Massironi | 129 | 1115 | 78457 |
Marco Pieri | 129 | 1285 | 82914 |
Cristina Riccardi | 129 | 1627 | 91452 |