University of Milano-Bicocca

About: University of Milano-Bicocca is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Population & Blood pressure. The organization has 8972 authors who have published 22322 publications receiving 620484 citations. The organization is also known as: Università degli Studi di Milano-Bicocca & Universita degli Studi di Milano-Bicocca.

Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update

Abstract: Toll-like receptor 4 (TLR4), together with MD-2, binds bacterial endotoxins (E) with high affinity, triggering formation of the activated homodimer (E.MD-2.TLR4)2. Activated TLR4 induces intracellular signaling leading to activation of transcription factors that result in cytokine and chemokine production and initiation of inflammatory and immune responses. TLR4 also responds to endogenous ligands called danger associated molecular patterns (DAMPs). Increased sensitivity to infection and a variety of immune pathologies have been associated with either too little or too much TLR4 activation. We review here the molecular mechanisms of TLR4 activation (agonism) or inhibition (antagonism) by small organic molecules of both natural and synthetic origin. The role of co-receptors MD-2 and CD14 in the TLR4 modulation process is also discussed. Recent achievements in the field of chemical TLR4 modulation are reviewed, with special focus on nonclassical TLR4 ligands with a chemical structure different from that of lipid A.

Key challenges for enabling agile BPM with social software

Abstract: Business Process Management is called agile when it is able to react quickly and adequately to internal and external events. Agile Business Process Management requires putting the life cycle of business processes on a new paradigm. It is advocated in this paper that social software allows us to satisfy the key requirements for enabling agile BPM by applying the four features of social software: weak ties, social production, egalitarianism and mutual service provision. Organizational and semantic integration and responsiveness (of the business processes engineering, execution and management activities) have been identified as the main requirements for implementing an agile BPM life cycle. Social software may be used in the BPM life cycle in several manners and using numerous approaches. This paper presents seven among them and then analyzes the ‘support’ effects between those approaches and the underlying social software features, and the three requirements for Agile BPM. Copyright © 2011 John Wiley & Sons, Ltd.