University of Ottawa

About: University of Ottawa is a education organization based out in Ottawa, Ontario, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 36763 authors who have published 87034 publications receiving 2913651 citations. The organization is also known as: uOttawa & U of O.

Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress disorder, and psychological distress among populations affected by the COVID-19 pandemic: A systematic review and meta-analysis.

Abstract: Objective We conducted a systematic review and meta-analysis to estimate the pooled prevalence of depression, anxiety, insomnia, PTSD, and Psychological distress (PD) related to COVID-19 among affected populations. Methods We searched articles in Medline, Embase, APA PsycInfo, CINAHL, Scopus, and Web of Science. Random-effects meta-analyses on the proportions of individuals with symptoms of depression, anxiety, insomnia, PTSD, and PD were generated and between-group differences for gender, healthcare workers (HCWs), and regions where studies were conducted. Results A total of 2189 articles were screened, 136 full-text articles were assessed for eligibility. Fifty-five peer-reviewed studies met inclusion criteria for the meta-analysis (N=189,159). The prevalence of depression (k=46) was 15.97% (95%CI, 13.24-19.13). The prevalence of anxiety (k=54) was 15.15% (95%CI, 12.29-18.54). The prevalence of insomnia (k=14) was 23.87% (95%CI, 15.74-34.48). The prevalence of PTSD (k=13) was 21.94% (95%CI, 9.37-43.31). Finally, the prevalence of psychological distress (k=19) was 13.29% (95%CI, 8.80-19.57). Between-group differences were only found in HCWs (z=2.69, p Conclusions Findings suggest that the short-term mental health consequences of COVID-19 are equally high across affected countries, and across gender. However, reports of insomnia are significantly higher among HCWs than the general population.

A polynuclear lanthanide single-molecule magnet with a record anisotropic barrier.

Abstract: Single-molecule magnets (SMMs) continue to be an attractive research field because of their unique and intriguing properties and potential applications in high-density data storage technologies and molecular spintronics. The anisotropic barrier (U) of an SMM is derived from a combination of an appreciable spin ground state (S) and uniaxial Ising-like magneto-anisotropy (D). The magnet-like behavior can be observed by slow relaxation of the magnetization below the blocking temperature. Since the discovery of SMMs in the early 1990s, this assumption has formed the basis for the understanding of the origin of the anisotropic barrier. However, in recent years the development of novel lanthanide-only SMMs that challenge and defy this theory pose a number of questions: How can slow relaxation of the magnetization be observed in a nonmagnetic state complex? Why are large energy barriers seen for mononuclear lanthanide(III) complexes? To answer such important questions, it is vital to investigate novel SMMs with high magnetoanisotropy for which the influence of the large negative D value could result in higher anisotropic barriers. Clearly lanthanide-based polynuclear systems are an important avenue to explore in the pursuit of SMMs with higher anisotropic barriers, because of the strong spin–orbit coupling commonly observed in 4f systems. However, lanthanide-only SMMs are rare. The majority of reported SMMs have been prepared with transition-metal ions, although the recent application of a mixed transition-metal/ lanthanide strategy also yielded many structurally and magnetically interesting systems. The scarcity of lanthanide-only SMMs results from the difficulty in promoting magnetic interactions between the lanthanide ions. The interactions can, however, be enhanced by overlapping bridging ligand orbitals. In addition, fast quantum tunneling of the magnetization (QTM), which is common for lanthanide systems, generally prevents the isolation of SMMs with high anisotropic energy barriers. Our recent work suggests that dysprosium(III) ions may hold the key to obtaining high-blocking-temperature lanthanide-only SMMs. When an appropriate ligand system is employed, it is possible to exploit the large intrinsic magnetoanisotropy, high spin, and reduced QTM that dysprosium(III) ions offer. Recently, we have focused our attention towards the synthesis of dysprosium(III) cluster complexes with 1,2bis(2-hydroxy-3-methoxybenzylidene) hydrazone (H2bmh) and 3-methoxysalicylaldehyde hydrazone (Hmsh) as chelating agents (see Figure S1 in the Supporting Information). This strategy has proven to be successful and has led to a polynuclear lanthanide SMM with a record anisotropic barrier. Herein, we report the synthesis, structure, and magnetism of a tetranuclear dysprosium(III) SMM that exhibits the largest relaxation barrier seen for any polynuclear SMM to date. A suspension of DyCl3·6H2O and o-vanillin (2:1 ratio) in DMF/CH2Cl2 (1:5 ratio) was treated with 4 equivalents of Et3N. The solution was stirred for 1 minute, and then 4 equivalents of N2H4·H2O was added. The resulting yellow solution yielded rectangular, orange-yellow crystals of the tetranuclear complex [Dy4(m3-OH)2(bmh)2(msh)4Cl2] (1) in 19.1% yield after 2 days. The msh and bmh ligands were formed in situ by the reaction of o-vanillin and hydrazine. The slight excess of hydrazine is essential for the formation of both ligands; when an excess of o-vanillin was used instead, no product was isolated. The basic conditions promote the deprotonation of the ligands and the formation of bridging hydroxide anions. Single-crystal X-ray analysis revealed the centrosymmetric complex 1 (Figure 1), which has a defect-dicubane central core. The four coplanar Dy ions are bridged by two m3-OH ligands displaced above and below (0.922 ) the Dy4 plane with Dy O bond lengths of 2.362(6), 2.302(6), and 2.447(6) andDy O Dy angles of 106.5(2), 107.7(2), and 105.7(2)8, and also by a combination of four phenoxide oxygen atoms [Dy O 2.312(2), 2.298(6), 2.448(6), 2.345(6) ] and two diaza bridging groups [Dy N 2.508(8), 2.564(8) ]. Close inspection of the packing arrangement reveals stacking of the [*] P.-H. Lin, Dr. T. J. Burchell, Dr. M. Murugesu Chemistry Department, University of Ottawa and Centre for Catalysis Research and Innovation D’Iorio Hall, 10 Marie Curie, Ottawa, ON, K1N6N5 (Canada) Fax: (+1)613-562-5170 E-mail: m.murugesu@uottawa.ca Homepage: http://www.science.uottawa.ca/~mmuruges/

CONSORT for Reporting Randomized Controlled Trials in Journal and Conference Abstracts: Explanation and Elaboration

Abstract: Background Clear, transparent, and sufficiently detailed abstracts of conferences and journal articles related to randomized controlled trials (RCTs) are important, because readers often base their assessment of a trial solely on information in the abstract Here, we extend the CONSORT (Consolidated Standards of Reporting Trials) Statement to develop a minimum list of essential items, which authors should consider when reporting the results of a RCT in any journal or conference abstract