Showing papers by "University of Rouen published in 1985"
TL;DR: The distribution of neuropeptide Y (NPY) in the central nervous system of the frog Rana ridibunda was determined by immunofluorescence using a highly specific antiserum and revealed that infundibulum, preoptic area and telencephalon extracts contained a major peptide bearing NPY-like immunoreactivity.
154 citations
TL;DR: In this paper, a formalism using Bromwich scalar potentials is given to compute the properties of the light scattered by a Mie scatter center illuminated by a Gaussian beam, including the intensities, phase angle, cross-sections and efficiency factors.
Abstract: A formalism using Bromwich scalar potentials is given to compute the properties of the light scattered by a Mie scatter center illuminated by a Gaussian beam. Formulae are established for the intensities, phase angle, cross-sections and efficiency factors, and radiation pressure.
121 citations
TL;DR: In this article, continuous swamp and lacustrine sequences from the northern edge of the Great Western Erg are dated at 9,300-3,000 yr BP, and the stable isotope composition of carbonates indicates that evaporation of groundwater supplies is responsible for these fluctuations in salt contents.
Abstract: Continuous swamp and lacustrine sequences from the northern edge of the Great Western Erg are dated at 9,300–3,000 yr BP. Diatoms, ostracods, molluscs and foraminifera show great changes in salinity, ranging from freshwater to marine-like environments. The stable isotope composition of carbonates indicates that the evaporation of groundwater supplies is responsible for these fluctuations in salt contents. Until now, evidence for the occurrence of a wet climatic phase of early and middle holocene age in the north-north-west Sahara was based on a restricted number of 14C dates from scattered lacustrine deposits and paleosols1–8. The present study complements this knowledge and highlights the importance of local hydrological factors in interpreting palaeolimnological changes.
120 citations
TL;DR: In this article, a simple and reproducible method of synthesizing enantiomers of benzyl malolactonate is described starting from optically active aspartic acid.
Abstract: A simple and reproducible method of synthesizing enantiomers of benzyl malolactonate is described starting from optically active aspartic acid. Chiral benzyl malolactonate is a β-substituted β-lactone monomer which can be readily polymerized anionically using triethylamine as the initiator to yield poly(benzyl β-malate) which is an optically active, semicrystalline polymer. Cleavage of protecting benzyl ester groups yields optically active poly(β-malic acid). The properties of the racemic and optically active monomers and polymers are compared. Optically active (−)poly(β-malic acid) shows one accessible positive CD band in the far UV.
118 citations
TL;DR: The results show that the rat's optokinetic system is qualitatively similar to that found in another lateral-eyed species, namely the rabbit, at a quantitative level, however, both fast and slowoptokinetic response dynamics appear to be better developed in the rat than in the rabbit.
103 citations
TL;DR: In this article, a fractionation of Acacia senegal gum has been carried out on Sephacryl gels S-400 and S-500 and the shape and relative height of the chromatograms are sample dependent.
81 citations
TL;DR: It is shown that the rate of degradation obeys first order kinetics at the begining and that poly(β-malic acid) degrades to malic acid at last.
Abstract: Poly(β-malic acid) is a new synthetic functional polyester of the poly(β-hydroxy-acid)-type whose properties are investigated in regard to possible uses as bioresorbable polyvalent drug-carrier. Degradation of polymer chains in 0.15 N phosphate buffer at pH=7.5 is monitored by aqueous GPC on SEPHADEX gels and by enzymatic titration of ultimate degradation products. It is shown that the rate of degradation obeys first order kinetics at the begining and that poly(β-malic acid) degrades to malic acid at last.
80 citations
TL;DR: It is confirmed that acetylcholine is probably the transmitter released from centrally arising vestibular efferents, and it is demonstrated that efferent-mediated effects are predominantly expressed through nicotinic receptors.
74 citations
TL;DR: Six viral polypeptides P81, P60, P31, P17, P13, and P10 were revealed to possess high affinity for CIV DNA, and a structural model of CIV is proposed and discussed.
48 citations
TL;DR: Analysis of 3H serotonin uptake by striatal synaptosomes showed that steady state 3H antidepressants levels were lower in alcohol preferring rats, in agreement with the hypothesis of a modulation of the voluntary intake of ethanol both by chemical and housing stimulation of striatal receptors for serotonin.
Abstract: Ethanol preferring rats were selected and showed a constant voluntary intake of a 12 percent ethanol solution during 14 days (about 5 g/kg body weight daily). Analysis of 3H serotonin uptake by striatal synaptosomes showed that steady state 3H serotonin synaptosomal levels were lower in alcohol preferring rats. Grouping these rats (5 per cage) reduced both voluntary intake of ethanol and synaptosomal 3H serotonin uptake. Furthermore, blocking the serotonin uptake by clomipramine 5 mg X kg-1 or 10 mg X kg-1 also reduces voluntary intake of ethanol. These data are in agreement with the hypothesis of a modulation of the voluntary intake of ethanol both by chemical and housing stimulation of striatal receptors for serotonin.
39 citations
TL;DR: Dopamine was shown to be less potent in inhibiting the release of des-N alpha-acetyl alpha-MSH than inhibiting release of the acetylated form of the peptide, suggesting that in amphibians a preferentialRelease of the less-bioactive non-acetelated formof MSH under inhibitory conditions induced by dopamine may be of physiological importance.
TL;DR: The elimination kinetics of aztreonam (SQ 26,776), a new, completely synthetic, monocyclic β-lactam antibiotic, were studied after the administration of a single 1g intravenous dose and there was a linear correlation between the serum clearance of azTreonam and creatinine clearance.
Abstract: The elimination kinetics of aztreonam (SQ 26,776), a new, completely synthetic, monocyclic beta-lactam antibiotic, were studied after the administration of a single 1g intravenous dose. Five healthy volunteers and 20 patients with various degrees of renal insufficiency were enrolled in this study. Concentrations of aztreonam in serum and urine were determined by both microbiological and high pressure liquid chromatography (HPLC) assays. The pharmacokinetic parameters for aztreonam were calculated on the basis of a 2-compartment open model. Serum concentrations of aztreonam at 10 minutes after administration were approximately 100 micrograms/ml in all subjects, regardless of renal function (HPLC assay). The mean serum half-life during the alpha-phase showed no important variation with renal function. The mean serum half-life during the beta-phase was 1.8 hours in normal subjects and 8.4 hours in haemodialysis patients (HPLC assay). There was a linear correlation between the serum clearance of aztreonam and creatinine clearance. The mean cumulative urinary recovery of aztreonam in 48 hours was 60 to 70% of the administered dose in normal subjects but this was reduced in the presence of renal insufficiency. SQ 26,992, the microbiologically inactive metabolite of aztreonam resulting from hydrolytic opening of the beta-lactam ring, was undetectable in the serum of normal subjects but was found in low levels in uraemic patients. Half of a 1g intravenous dose of aztreonam was eliminated during 4 hours of haemodialysis. Guidelines for administration of aztreonam in the presence of renal failure are given.
TL;DR: The results demonstrate that the dicarboxylate carrier of rat mitochondria can be obtained in an advanced state of purification and with a high specific activity.
TL;DR: In this article, a new class of cyclic telluronium salts has been prepared and all the salts are stable in solution in CHCl 3 or dimethylsulphoxide (DMSO).
TL;DR: In this article, it was shown that drugs reputedly insoluble in water can be dissolved and temporarily trapped in a lipophilic microphase in a poly-[thio-1-(N,N-diethyl aminomethyl) ethylene] type with less than 20% quaternized repeating units.
TL;DR: In this article, the average radiative transition probabilities for argon atoms have been calculated for transitions between 24 levels in two groups characterized by the atomic core terms 2P1/2 and 2P3/2 by using the method of Bates and Damgaard.
Abstract: Average radiative transition probabilities for argon atoms have been calculated for transitions between 24 levels in two groups characterized by the atomic core terms 2P1/2 and 2P3/2 by using the method of Bates and Damgaard. The results are compared with data in the NBS tables (Wiese et al.) and with those of Katsonis and Drawin. We find satisfactory agreement for the order of magnitude, even for transitions between lower lying levels. Parameters, which appear in Drawin's semiempirical cross-section expressions for electronic excitation of optically allowed and parity-forbidden transitions, are determined with the multipole expansion method proposed by Sobel'man for transitions between the specified levels. Most of these are easily obtained, but the method must be improved for transitions between levels having the same azimuthal quantum number because the summation over the constituent terms does not converge.
TL;DR: For example, β-Bromoenol ethers readily undergo bromine-lithium exchange with t-butyllithium in ether or THF at −70°C as mentioned in this paper.
TL;DR: This Letter presents a method to derive absolute OH concentration in a diffusion flame from linear LIF measurement in non-negligible absorption conditions and takes advantage of the fluorescence profile dissymmetry to derive local absolute concentration of OH from absorption of the laser beam.
Abstract: Accurate determination of the absolute number density of species from laser-induced fluorescence measurement is difficult; the rate of fluorescence quenching due to collisional deexcitation is not sufficiently well known in flames, and numerous uncertainties about dye laser power, fluorescence trapping, collection aperture, and detector sensitivity accu mulate. In this Letter we present a method we have used to derive absolute OH concentration in a diffusion flame from linear LIF measurement in non-negligible absorption conditions. The conic diffusion flame is set up above a cylindrical po rous burner supplied with two coflowing streams (CH4 inside, air peripheric).OH is excited by tuning a diametric pulsed laser beam on the Q16 line of the Σ(υ ′ = 0) ←2 π(υ′′ = 0) transition. The fluorescence light is collected at 90° and fo cused onto the aperture of a photomultiplier connected to a boxcar averager. Transverse exploration of the flame is re alized by translating the burner parallel to the laser beam. The fluorescence profile shows two peaks corresponding to the two intersections of the conic flame by the laser beam, but the first fluorescence peak is always higher than the second (Fig. 1); this dissymmetry is only due to the noticeable ab sorption of the laser beam during its path through the first flame front as confirmed by a half-revolution of the burner. This problem can be overcome by choosing a more weakly absorbing line corresponding to a level with a lower popula tion, but the fluorescence intensity would be reduced and would be temperature dependent as the population of such a level located on the wing of the Boltzmann distribution function is. Thus we have decided to maintain our situation where the ratio of the π,υ′′ = 0, J′′ = 6 involved population to the total OH population is not significantly dependent on the temperature and to take advantage of our fluorescence profile dissymmetry to derive local absolute concentration of OH from absorption of the laser beam.
TL;DR: In this paper, the authors discuss the necessity of facteur d'un mot imprimitif appartenant a x+y ∪ xy++ ∪ X+y+ ∫ xy+.
TL;DR: A gas chromatographic--mass spectrometric technique is proposed for the analysis of volatile amines which were isolated from Clostridium cultures by vacuum distillation and concentrated as hydrochloride salts.
TL;DR: Le but de cet article est de determiner l'ensemble C(u)={v∈A * /uv=vu|θ|}, qui est equivalent a determiner pour n=f(u), l'enser C(n)={n'∈Mθ(A)/nn'=n'n}
TL;DR: Results provide immunocytological evidence for the presence of endogenous TRH and NPY in frog melanotrophs indicating that these peptides may participate in the regulation of intermediate lobe secretion.
TL;DR: The postconcussion syndrome is not subjective and that the neck injury is primary in the determination of the syndrome, and results are in agreement with the hypothesis that a change in brain amines metabolism could explain the different functional effects of whiplash.
Abstract: Two days after an experimental whiplash performed on anesthetized Long-Evans female rats, without any direct blow to the head, we observed: (1) a hypotension (in supine position) (P less than 0.01), (2) a disturbance of the postural regulation of cerebral blood flow (P less than 0.01), (3) a disturbance of learning behavior characterized by decreased acquisition and retention (conditioned avoidance response and labyrinth tests), (4) an increase of the dopamine level (whole brain, cerebellum, thalamus + hypothalamus, corpus striatum and rest), (5) a decrease of the noradrenaline level in whole brain (P less than 0.05) and in the medulla oblongata but an increase in thalamus plus hypothalamus, hippocampus and corpus striatum, (6) an increased reactivity of the peripheral alpha and beta receptors, determined by analyzing the hemodynamic consequences of i.v. injection of norepinephrine or isoproterenol, (7) there was no modification of the brain content of water or of serotonin and (8) finally, the injured rats displayed a remarkably aggressive behavior, though this was not quantified. These results are in agreement with the hypothesis that a change in brain amines metabolism could explain the different functional effects of whiplash. We therefore believe that the postconcussion syndrome is not subjective and that the neck injury is primary in the determination of the syndrome.
TL;DR: A novel globular partially quaternized polymer has been used as a carrier system for the intravenous administration of a labelled steroid to rabbits and the greater quantity of the observed activity was found in the liver/spleen area whereas less activity appeared in the lung/heart region.
TL;DR: Synthesis of the polypeptides induced in CIV-infected cells was studied using radiolabelled methionine in a permissive cell line of Choristoneura fumiferana to reveal the sequential appearance of at least 28 structural and non-structural polyPEptides in permissive conditions.
Abstract: Synthesis of the polypeptides induced in CIV-infected cells was studied using radiolabelled methionine in a permissive cell line ofChoristoneura fumiferana.
TL;DR: The results suggest that compounds such as prorenone (SC 23133), SC 19886 and spironolactone, which are potent inhibitors of aldosterone biosynthesis could be more active in the treatment of primary aldosteronism than those antimineralocorticoids which are devoid of action on ald testosterone biosynthesis.
TL;DR: A 2-oxoglutarate dehydrogenase complex activity is demonstrated in Neurospora crassa mitochondria and the pyruvate dehydrogen enzyme activity is also found to be localized in the matrix.
TL;DR: In this paper, a theoretical and experimental investigation of cold wire frequency response for the case of heated airflows (T < 600 K) is presented for the purpose of analyzing the influence of temperature on cold wire transfer function characteristics (timeconstant and plateau level).
Abstract: A theoretical and experimental investigation of cold wire frequency response is presented for the case of heated airflows (T < 600 K). Experiments using an external heating technique have been carried out for sensors in different flow situations. Particular attention has been paid to the influence of temperature on cold wire transfer function characteristics (time-constant and plateau level).
01 Jan 1985
TL;DR: In this paper, a model for non-homogeneous turbulent flow fields is proposed that is able to handle multispecies, non-infinitely fast chemistry in a turbulent medium.
Abstract: Turbulent combustion is discussed from a Lagrangian point of view. It is shown that simple models can be derived, or already known models can be very well explained. In the case of non-homogeneous turbulent flow field, a model is proposed that is able to handle multispecies, non-infinitely fast chemistry in a turbulent medium.