University of the Philippines

About: University of the Philippines is a education organization based out in Quezon City, Philippines. It is known for research contribution in the topics: Population & Health care. The organization has 4589 authors who have published 4437 publications receiving 114846 citations. The organization is also known as: UP.

Some Issues in Infonnation Transfer: A Third World Perspective:

Abstract: tems. Developing the systems and mechanisms that facilitate awareness of and access to information sources have been two of the major concerns of library and information science 1. The barriers to and problems of, access to information sources, especially documents, are well recognized although the available solutions may not be perfect. International inter-governmental organizations such as Unesco and other UN agencies and non-governmental organizations such as IFLA, FID, ICA and ICSU

Amantelides A and B, Polyhydroxylated Macrolides with Differential Broad-Spectrum Cytotoxicity from a Guamanian Marine Cyanobacterium

Abstract: Cytotoxicity-guided fractionation of a Guamanian cyanobacterial collection yielded the new compounds amantelides A (1) and B (2). These polyketides are characterized by a 40-membered macrolactone ring consisting of a 1,3-diol and contiguous 1,5-diol units and a tert-butyl substituent. Amantelide A (1) displayed potent cytotoxicity with submicromolar IC50 against HT29 colorectal adenocarcinoma and HeLa cervical carcinoma cell lines. Acetylation of the hydroxy group at C-33 in 2 caused a close to 10-fold decrease in potency. Exhaustive acetylation of the hydroxy groups abrogated the antiproliferative activity of amantelide A (1) by 20–67-fold. Further bioactivity assessment of 1 against bacterial pathogens and marine fungi indicated a broad spectrum of bioactivity.

Avalanche Statistics of Driven Granular Slides in a Miniature Mound

Abstract: We examine avalanche statistics of rain- and vibration-driven granular slides in miniature sand mounds. A crossover from power-law to non power-law avalanche-size statistics is demonstrated as a generic driving rate $ u$ is increased. For slowly-driven mounds, the tail of the avalanche-size distribution is a power-law with exponent $-1.97\pm 0.31$, reasonably close to the value previously reported for landslide volumes. The interevent occurrence times are also analyzed for slowly-driven mounds; its distribution exhibits a power-law with exponent $-2.670\pm 0.001$.

Epidemiology, prevention and treatment of cervical cancer in the Philippines.

Abstract: Cervical cancer remains to be one of the leading malignancies among Filipino women. High-risk human papillomavirus (HPV) types, such as 16 and 18, are consistently identified in Filipino women with cervical cancer. Factors identified to increase the likelihood of HPV infection and subsequent development of cervical cancer include young age at first intercourse, low socioeconomic status, high parity, smoking, use of oral contraception and risky sexual behaviors. Cancer screening programs presently available in the Philippines include Pap smears, single visit approach utilizing visual inspection with acetic acid followed by cryotherapy, as well as colposcopy. However, the uptake of screening remains low and is further compounded by the lack of basic knowledge women have regarding screening as an opportunity for prevention of cervical cancer. Prophylactic HPV vaccination of both quadrivalent and bivalent vaccines has already been approved in the Philippines and is gaining popularity among the Filipinos. However, there has been no national or government vaccination policy implemented as of yet. The standard of treatment of cervical cancer is radiotherapy concurrent with chemotherapy. Current researches are directed towards improving availability of both preventive and curative measures of cervical cancer management.