Institution
University of Western Ontario
Education•London, Ontario, Canada•
About: University of Western Ontario is a education organization based out in London, Ontario, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 46971 authors who have published 99859 publications receiving 3741703 citations. The organization is also known as: UWO & University of Western Ontario.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors present a novel control strategy for achieving maximum benefits from these grid-interfacing inverters when installed in 3-phase 4-wire distribution systems, where the inverter is controlled to perform as a multi-function device by incorporating active power filter functionality.
Abstract: Renewable energy resources (RES) are being increasingly connected in distribution systems utilizing power electronic converters. This paper presents a novel control strategy for achieving maximum benefits from these grid-interfacing inverters when installed in 3-phase 4-wire distribution systems. The inverter is controlled to perform as a multi-function device by incorporating active power filter functionality. The inverter can thus be utilized as: 1) power converter to inject power generated from RES to the grid, and 2) shunt APF to compensate current unbalance, load current harmonics, load reactive power demand and load neutral current. All of these functions may be accomplished either individually or simultaneously. With such a control, the combination of grid-interfacing inverter and the 3-phase 4-wire linear/non-linear unbalanced load at point of common coupling appears as balanced linear load to the grid. This new control concept is demonstrated with extensive MATLAB/Simulink simulation studies and validated through digital signal processor-based laboratory experimental results.
428 citations
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TL;DR: This is the first SRM active surveillance study to correlate growth with histology prospectively, and shows that SRMs appear to grow very slowly, even if biopsy proven to be RCC.
428 citations
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TL;DR: Approaches that have been attempted in the development of 3-D ultrasound imaging such as3-D B-mode, color Doppler, and power doppler systems are reviewed.
Abstract: The development of 3-D ultrasound imaging is a way to address the disadvantages of conventional ultrasound imaging. In this article the authors review approaches that have been attempted in the development of 3-D ultrasound imaging such as 3-D B-mode, color Doppler, and power Doppler systems. Acquisition, reconstruction, and rendering techniques for 3-D imaging are discussed, as well as applications and limitations.
428 citations
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TL;DR: The possibility that therapeutic decisions at the time of diagnosis might be tailored to particular genetic subtypes of anaplastic oligodendroglioma is raised, for the first time, in this group of patients in whom therapeutic management was not uniform.
Abstract: Purpose: In a prior study of anaplastic oligodendrogliomas treated with chemotherapy at diagnosis or at recurrence after radiotherapy, allelic loss of chromosome 1p correlated with better chemotherapeutic response and overall survival. However, in this group of patients in whom therapeutic management was not uniform, loss of 1p did not identify all chemosensitive tumors, nor did all patients whose tumors harbor a 1p loss have long survival. Experimental Design: To clarify the clinical relevance of molecular genetic testing at the time of diagnosis for patients with anaplastic oligodendrogliomas, we studied a larger, more homogeneous group of 50 patients with histologically defined anaplastic oligodendrogliomas treated with a chemotherapeutic regimen as the principal initial therapy. Results: We demonstrate that these tumors can be divided genetically into four therapeutically and prognostically relevant subgroups. Patients whose tumors have combined but isolated losses of 1p and 19q have marked and durable responses to chemotherapy associated with long survival, with or without postoperative radiation therapy. Other tumors with chromosome 1p alterations also respond to chemotherapy, but with shorter duration of response and patient survival. Tumors lacking 1p loss can also be divided into two subgroups: those with TP53 mutations, which may also respond to chemotherapy but recur quickly, and those without TP53 mutations, which are poorly responsive, aggressive tumors that are clinically and genotypically similar to glioblastomas. Conclusions: These data raise the possibility, for the first time, that therapeutic decisions at the time of diagnosis might be tailored to particular genetic subtypes of anaplastic oligodendroglioma.
428 citations
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TL;DR: An accumulation of rare variants, or a mutation skew, in GWAS-identified genes in individuals with hypertriglyceridemia are shown, and considering rare variants in these genes incrementally increased the proportion of genetic variation contributing to HTG.
Abstract: Genome-wide association studies (GWAS) have identified multiple loci associated with plasma lipid concentrations. Common variants at these loci together explain <10% of variation in each lipid trait. Rare variants with large individual effects may also contribute to the heritability of lipid traits; however, the extent to which rare variants affect lipid phenotypes remains to be determined. Here we show an accumulation of rare variants, or a mutation skew, in GWAS-identified genes in individuals with hypertriglyceridemia (HTG). Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG. Resequencing of these genes revealed a significant burden of 154 rare missense or nonsense variants in 438 individuals with HTG, compared to 53 variants in 327 controls (P = 6.2 x 10(-8)), corresponding to a carrier frequency of 28.1% of affected individuals and 15.3% of controls (P = 2.6 x 10(-5)). Considering rare variants in these genes incrementally increased the proportion of genetic variation contributing to HTG.
427 citations
Authors
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Name | H-index | Papers | Citations |
---|---|---|---|
Gordon H. Guyatt | 231 | 1620 | 228631 |
Nicholas G. Martin | 192 | 1770 | 161952 |
Deborah J. Cook | 173 | 907 | 148928 |
William J. Sandborn | 162 | 1317 | 108564 |
Jean Louis Vincent | 161 | 1667 | 163721 |
Peter B. Reich | 159 | 790 | 110377 |
Paul Emery | 158 | 1314 | 121293 |
Bruce D. Walker | 155 | 779 | 86020 |
William A. Goddard | 151 | 1653 | 123322 |
György Buzsáki | 150 | 446 | 96433 |
Carlo Rovelli | 146 | 1502 | 103550 |
Michael J. Keating | 140 | 1169 | 76353 |
Shuit-Tong Lee | 138 | 1121 | 77112 |
Graeme J. Hankey | 137 | 844 | 143373 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |